Author: Sarangam Majumdar
Publisher: Springer Nature
ISBN: 9811574170
Category : Science
Languages : en
Pages : 182
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Book Description
This book introduces the concept of bacterial communication systems from a mathematical modeling point of view. It sheds light on the research undertaken in the last three decades, and the mathematical models that have been proposed to understand the underlying mechanism of such systems. These communication systems are related to quorum sensing mechanisms and quorum sensing regulated processes such as biofilm formation, gene expression, bioluminescence, swarming and virulence. The book further describes the phenomenon of noise, and discusses how noise plays a crucial role in gene expression and the quorum sensing circuit operationusing a set of tools like frequency domain analysis, power spectral density, stochastic simulation and the whitening effect. It also explores various aspects of synthetic biology (related to bacterial communication), such as genetic toggle switch, bistable gene regulatory networks, transcriptional repressor systems, pattern formation, synthetic cooperation, predator-prey synthetic systems, dynamical quorum sensing, synchronized quorum of genetic clocks, role of noise in synthetic biology, the Turing test and stochastic Turing test.
Author: Donald R. Demuth
Publisher: Cambridge University Press
ISBN: 9781139447973
Category : Science
Languages : en
Pages : 340
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Book Description
Many bacterial diseases are caused by organisms growing together as communities or biofilms. These microorganisms have the capacity to coordinately regulate specific sets of genes by sensing and communicating amongst themselves utilizing a variety of signals. This book examines the mechanisms of quorum sensing and cell-to-cell communication in bacteria and the roles that these processes play in regulating virulence, bacterial interactions with host tissues, and microbial development. Recent studies suggest that microbial cell-to-cell communication plays an important role in the pathogenesis of a variety of disease processes. Furthermore, some bacterial signal molecules may possess immunomodulatory activity. Thus, understanding the mechanisms and outcomes of bacterial cell-to-cell communication has important implications for appreciating host-pathogen interactions and ultimately may provide new targets for antimicrobial therapies that block or interfere with these communication networks.
Author: Society for General Microbiology. Symposium
Publisher: Cambridge University Press
ISBN: 9780521652612
Category : Medical
Languages : en
Pages : 386
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Book Description
Presents information at the forefront of this exciting field and includes contributions on a range of organisms and signalling molecules.
Author: Marco Gobbetti
Publisher: Springer Science & Business Media
ISBN: 1461456568
Category : Technology & Engineering
Languages : en
Pages : 85
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Book Description
It is generally assumed that microorganisms synthesize, release, detect and respond to small signaling hormone-like molecules. These molecules are used for a process termed “quorum sensing” (QS), a phenomenon that enables bacteria to sense when the minimal number of cells, or “quorum,” is achieved for a concerted response to be initiated. Words such as “language” and “behavior” are frequently used to depict QS in the literature. More simply put, language and cross-talk between bacteria, and between bacteria and animal or plant hosts, determines the behavior (e.g., beneficial or pathogenic effects) of bacteria. Currently, the major concern is to understand and decode this language. Overall, bacterial cross-talk was mainly studied on environmental, plant, and human pathogenic bacteria. Few studies considered food-related lactic acid bacteria. The cross-talk between bacteria influences the behavior and, in turn, the environmental adaptation and phenotypes. Therefore, it is understood that bacterial cross-talk has important applicative repercussions. The language spoken between bacteria populating the same food ecosystem may condition the phenotypic traits of starter lactic acid bacteria and, consequently, their performance. This Brief aims to define the basis of cell-to-cell signalling in food fermentation and will highlight: (i) microbiology, nutritional, chemical and functional aspects; (ii) functional properties due to microbial adaptation to the gastrointestinal tract; (iii) principal phenotypes under control of QS circuitries; (iv) quorum quenching. This Brief will be the first reference on this topic and it will highlight the main results for a more productive industrial application. Draft content 1. Signals of food related Gram-negative and Gram-positive bacteria The chapter will describe the different signaling languages used by Gram-negative bacteria (N-acyl-L-homoserine lactones) and Gram-positive bacteria (based on the synthesis of post-translationally modified peptides) and the universal chemical lexicon, shared by both Gram-positive and -negative bacteria (autoinducer-2 through the activity of the LuxS enzyme). 2. Phenotypes related to quorum sensing The chapter will describe the bacterial phenotypes, such as virulence, biofilm maturation, bacteriocin synthesis, and secondary metabolite production under control of QS circuitries. 3. Cell-to-cell signalling in fermented food: sourdough The chapter will describe the language spoken between bacteria populating the same food ecosystem (sourdough) and will provide an overview of the conditioned phenotypic traits of starter lactic acid bacteria and, consequently, their performance. 4. Cell-to-cell signalling in fermented food: yoghurt The chapter will describe the language spoken between bacteria populating the same food ecosystem (yoghurt) and will provide an overview of the conditioned phenotypic traits of starter lactic acid bacteria and, consequently, their performance. 5. Probiotic message at the intra-, inter-species and inter-kingdom level The chapter will describe the mechanisms that regulate the interaction between microorganism and host, and the capacity of the microorganism to adapt to environment. Particular reference will also be made to: (i) pathogen inhibition and restoration of microbial homeostasis through microbe-microbe interactions; (ii) enhancement of epithelial barrier function; and (iii) modulation of immune responses. 6. New Perspectives of quorum sensing This chapter will provide an overview of the future perspective regarding quorum sensing, showing that bacterial cross-talk may have important applicative repercussions. It will highlight the interference on the language of QS, which is defined as quorum quenching (QQ). Increasing translation of the bacterial cross-talk has shown that in some environmental circumstances, quenching of the language may occur.
Author: Stephen J. Hagen
Publisher: Springer
ISBN: 1493914022
Category : Science
Languages : en
Pages : 257
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Book Description
Quorum sensing (QS) describes a chemical communication behavior that is nearly universal among bacteria. Individual cells release a diffusible small molecule (an autoinducer) into their environment. A high concentration of this autoinducer serves as a signal of high population density, triggering new patterns of gene expression throughout the population. However QS is often much more complex than this simple census-taking behavior. Many QS bacteria produce and detect multiple autoinducers, which generate quorum signal cross talk with each other and with other bacterial species. QS gene regulatory networks respond to a range of physiological and environmental inputs in addition to autoinducer signals. While a host of individual QS systems have been characterized in great molecular and chemical detail, quorum communication raises many fundamental quantitative problems which are increasingly attracting the attention of physical scientists and mathematicians. Key questions include: What kinds of information can a bacterium gather about its environment through QS? What physical principles ultimately constrain the efficacy of diffusion-based communication? How do QS regulatory networks maximize information throughput while minimizing undesirable noise and cross talk? How does QS function in complex, spatially structured environments such as biofilms? Previous books and reviews have focused on the microbiology and biochemistry of QS. With contributions by leading scientists and mathematicians working in the field of physical biology, this volume examines the interplay of diffusion and signaling, collective and coupled dynamics of gene regulation, and spatiotemporal QS phenomena. Chapters will describe experimental studies of QS in natural and engineered or microfabricated bacterial environments, as well as modeling of QS on length scales spanning from the molecular to macroscopic. The book aims to educate physical scientists and quantitative-oriented biologists on the application of physics-based experiment and analysis, together with appropriate modeling, in the understanding and interpretation of the pervasive phenomenon of microbial quorum communication.
Author: Alexander V. Oleskin
Publisher:
ISBN: 9781536175066
Category : Cell interaction
Languages : en
Pages : 389
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Book Description
"In light of recent data, microorganisms are construed in the present monograph as living organisms that are capable of communication and advanced social organization, which conspicuously manifests itself in the formation of extracellular matrix-enclosed biofilms. Microbial communication signals, including quorum sensing pheromones, are of paramount importance both for interactions among microbial cells and the dialogue between them and the host organism. The monograph sums up the facts that demonstrate the complexity of the human organism-inhabiting microbial consortium comprising a wide variety of biofilm-forming eukaryotic, bacterial and archean cells. The microbiota is involved in maintaining microecological, metabolic, epigenetic, neuro-endocrine and immune homeostasis that normally stabilizes the brain-gut-microbiota axis. Microbially produced neuroactive chemicals include peptides, amino acids, amines, short-chain fatty acids, purines and gaseous substances that are used as nutrients, effectors, cofactors and signals by the host organism. In the present-day world, the human organism has to deal with a large number of environmental stress factors that overpower the organism's protective system and disrupt the functioning of symbiotic microbiota predominantly located in the gastro-intestinal (GI) tract. Homeostasis disruption may impede communication between microbial cells and the human organism and cause physical or mental health problems. The operation of the brain-gut-microbiota axis can be improved by useful microorganisms (probiotics) including psychobiotics that directly impact the human brain and behavior. In the authors' opinion, the lifelong epigenetic developmental program of the organism can be ameliorated and genetic and epigenetic disruptions in the human metagenome (comprising all nuclear, mitochondrial and microbial genes) can be prevented by supplementing the diet with traditional, organic and individualized functional food items that relieve the effects of various detrimental stress factors and agents. A reasonably designed lifestyle based on gut microbiota optimization will undoubtedly help human individuals live a decent healthy life and attain active longevity. Current research on the population organization, social behavior and intercellular communication of microorganisms is expected to promote the interdisciplinary dialogue between microbiology, cytology and ethology. In addition, the results of this research are of significant potential importance for medicine and biotechnology"--
Author: Stephen Carlyle Winans
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 528
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Book Description
Summarizes the science and recent research developments of chemical communication among bacteria
Author: Alexander V. Oleskin
Publisher: Nova Science Publishers
ISBN: 9781536175073
Category : Science
Languages : en
Pages : 389
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Book Description
"In light of recent data, microorganisms are construed in the present monograph as living organisms that are capable of communication and advanced social organization, which conspicuously manifests itself in the formation of extracellular matrix-enclosed biofilms. Microbial communication signals, including quorum sensing pheromones, are of paramount importance both for interactions among microbial cells and the dialogue between them and the host organism. The monograph sums up the facts that demonstrate the complexity of the human organism-inhabiting microbial consortium comprising a wide variety of biofilm-forming eukaryotic, bacterial and archean cells. The microbiota is involved in maintaining microecological, metabolic, epigenetic, neuro-endocrine and immune homeostasis that normally stabilizes the brain-gut-microbiota axis. Microbially produced neuroactive chemicals include peptides, amino acids, amines, short-chain fatty acids, purines and gaseous substances that are used as nutrients, effectors, cofactors and signals by the host organism. In the present-day world, the human organism has to deal with a large number of environmental stress factors that overpower the organism's protective system and disrupt the functioning of symbiotic microbiota predominantly located in the gastro-intestinal (GI) tract. Homeostasis disruption may impede communication between microbial cells and the human organism and cause physical or mental health problems. The operation of the brain-gut-microbiota axis can be improved by useful microorganisms (probiotics) including psychobiotics that directly impact the human brain and behavior. In the authors' opinion, the lifelong epigenetic developmental program of the organism can be ameliorated and genetic and epigenetic disruptions in the human metagenome (comprising all nuclear, mitochondrial and microbial genes) can be prevented by supplementing the diet with traditional, organic and individualized functional food items that relieve the effects of various detrimental stress factors and agents. A reasonably designed lifestyle based on gut microbiota optimization will undoubtedly help human individuals live a decent healthy life and attain active longevity. Current research on the population organization, social behavior and intercellular communication of microorganisms is expected to promote the interdisciplinary dialogue between microbiology, cytology and ethology. In addition, the results of this research are of significant potential importance for medicine and biotechnology"--
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309264324
Category : Medical
Languages : en
Pages : 633
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Book Description
Beginning with the germ theory of disease in the 19th century and extending through most of the 20th century, microbes were believed to live their lives as solitary, unicellular, disease-causing organisms . This perception stemmed from the focus of most investigators on organisms that could be grown in the laboratory as cellular monocultures, often dispersed in liquid, and under ambient conditions of temperature, lighting, and humidity. Most such inquiries were designed to identify microbial pathogens by satisfying Koch's postulates.3 This pathogen-centric approach to the study of microorganisms produced a metaphorical "war" against these microbial invaders waged with antibiotic therapies, while simultaneously obscuring the dynamic relationships that exist among and between host organisms and their associated microorganisms-only a tiny fraction of which act as pathogens. Despite their obvious importance, very little is actually known about the processes and factors that influence the assembly, function, and stability of microbial communities. Gaining this knowledge will require a seismic shift away from the study of individual microbes in isolation to inquiries into the nature of diverse and often complex microbial communities, the forces that shape them, and their relationships with other communities and organisms, including their multicellular hosts. On March 6 and 7, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats hosted a public workshop to explore the emerging science of the "social biology" of microbial communities. Workshop presentations and discussions embraced a wide spectrum of topics, experimental systems, and theoretical perspectives representative of the current, multifaceted exploration of the microbial frontier. Participants discussed ecological, evolutionary, and genetic factors contributing to the assembly, function, and stability of microbial communities; how microbial communities adapt and respond to environmental stimuli; theoretical and experimental approaches to advance this nascent field; and potential applications of knowledge gained from the study of microbial communities for the improvement of human, animal, plant, and ecosystem health and toward a deeper understanding of microbial diversity and evolution. The Social Biology of Microbial Communities: Workshop Summary further explains the happenings of the workshop.
Author: Zhenhong Yuan
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 311042486X
Category : Technology & Engineering
Languages : en
Pages : 536
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Book Description
The book provides an overview on various microorganisms and their industrialization in energy conversion, such as ethanol fermentation, butanol fermentation, biogas fermentation and fossil energy conversion. It also covers microbial oil production, hydrogen production and electricity generation. The content is up to date and suits well for both researchers and industrial audiences.
