OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264071067
Category :
Languages : en
Pages : 8
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Book Description
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071067
Category :
Languages : en
Pages : 8
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Book Description
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Author: Robert L. Bronaugh
Publisher: CRC Press
ISBN: 9781420000948
Category : Science
Languages : en
Pages : 992
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Book Description
Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071083
Category :
Languages : en
Pages : 8
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Book Description
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Author: Michael S. Roberts
Publisher: CRC Press
ISBN: 0849375924
Category : Medical
Languages : en
Pages : 706
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Book Description
The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab
Author: Barbara W. Kemppainen
Publisher: CRC Press
ISBN: 1040290574
Category : Medical
Languages : en
Pages : 232
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Book Description
This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.
Author: Nina Dragicevic
Publisher: Springer
ISBN: 3662478625
Category : Medical
Languages : en
Pages : 387
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Book Description
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.
Author: Hans Schaefer
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Medical
Languages : en
Pages : 336
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Book Description
Skin Barrier is the first book to be written exclusively by researchers for researchers as a convenient desktop reference. It focuses on several key aspects of the skin barrier including composition and structure and a description of the properties governing the diffusion of compounds across the skin. Although there has been a large number of laboratories involved in measuring percutaneous absorption over the past 15 to 20 years, it is only recently that there has been a general consensus in the scientific community regarding the development of standard protocols. Recognizing the importance of this, the authors have included two chapters detailing the protocol used in measuring and predicting percutaneous absorption and a discussion on the practical application of these techniques to solve associated problems. In order to provide the researcher and especially the student with access to more detailed information, the book features a comprehensive listing of references published over the past 10 years. Skin Barrier is the only desktop reference for dermatologists, cosmetologists, biochemists, biologists, and those in the pharmaceutics industry, who need detailed and accurate information about the skin barrier on a daily basis. No R & D department should be without a copy.
Author: Kenji Sugibayashi
Publisher: Springer
ISBN: 4431565264
Category : Medical
Languages : en
Pages : 410
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Book Description
This book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, “Basic Formulations Applied to Skin”. The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents “Skin Penetration Enhancement”. In addition, Part 4, “Selection of Topically Applied Chemical Candidates”, deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, “Safety Assessment of Topically Applied Compounds“ and “Experimental Methods of Skin Permeation“, respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.
Author: H. Schaefer
Publisher: Springer Science & Business Media
ISBN: 3642687342
Category : Medical
Languages : en
Pages : 365
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Book Description
Author: Philippe Humbert
Publisher: Springer
ISBN: 9783319323817
Category : Medical
Languages : en
Pages : 0
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Book Description
Since the first edition of this book was published in 2004, to much acclaim, the pace of innovation in the field of skin metrology has increased and various new technologies have become available. This new, revised edition reflects these advances by presenting the current theory and practice of noninvasive investigation and measurement of the skin and its appendices in health and disease. The first, extensive part of this authoritative work is devoted to the physiology and metrology of the various structural components of the skin. Skin functions and their measurement are then discussed in detail, with sections on mechanical protection, photoprotection, barrier function, immune function, thermoregulation, and sensory function. In addition, careful consideration is given to skin disease rating and skin maps, and a unique list of physical and biological constants and units is provided. Not only is this new edition the first comprehensive, practical handbook in this domain – it will also serve as a manual of skin physiology and collates anatomical, functional, and physical quantitative data that would otherwise be arduous to retrieve because of their dispersal throughout the literature. It will prove a valuable resource for dermatologists, cosmetologists, bioengineers, physiologists, pharmacists, and all others who deal with the skin in their work.
