Author: Alfredo Ricci
Publisher: John Wiley & Sons
ISBN: 3527347399
Category : Science
Languages : en
Pages : 480
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Book Description
Discover a comprehensive overview of efficient synthetic routes to an important compound class in organic and pharmaceutical chemistry Methodologies in Amine Synthesis: Challenges and Applications delivers powerful and state-of-the-art methods for the efficient preparation of amines. The text summarizes recent advances in the electrophilic amination reaction, hydroamination, C-H amination and newly developed photocatalytic approaches. The distinguished editor has included resources that discuss organocatalytic and enzymatic routes to the generation of amines under mild and environmentally friendly conditions. The book also highlights the relevance of the amino function in bioactive molecules, drugs, and smart materials, as well as the palladium-catalyzed aromatic amination reaction. It presents efficient and practical synthetic methods, highlights the opportunities and challenges associated with each, and discusses their possible applications in pharmaceutical chemistry and materials science. Edited by the expert who wrote Modern Amination Methods and Amino Group Chemistry, the book includes a breadth and depth of material essential to the practice of academic and industrial chemists working in organic synthesis and catalysis. Readers will also benefit from the inclusion of: A thorough introduction to new openings and perspectives in the electrophilic amination Discussions of asymmetric catalysed hydroaminomethylation and amino organocatalysis A treatment of the synthetic application of transaminase or MAO biocatalysis to the synthesis of amines An exploration of recent developments in C-H amination, as well as photocatalytic approaches to the synthesis of amines An examination of primary amines from renewable bio-based resources Perfect for organic, natural product, catalytic, medicinal, and polymer chemists, Methodologies in Amine Synthesis: Challenges and Applications will also earn a place in the libraries of materials scientists and chemists working with organometallics who desire a one-stop reference edited by a well-known expert in the field.
Author: Alfredo Ricci
Publisher: John Wiley & Sons
ISBN: 3527826173
Category : Science
Languages : en
Pages : 480
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Book Description
Provides a unique overview of efficient synthetic routes to one of the most important compound classes in organic and pharmaceutical chemistry! Amines are among the most important compounds in organic chemistry due to their wide occurrence in natural products, drugs, crop protection compounds, and advanced materials. For example, the majority of drugs are amines or contain functional groups derived from amines. Powerful and efficient methods for the introduction of the amino group are therefore of great importance to synthetic chemists in academia and industry. Methodologies in Amine Synthesis: Challenges and Applications presents powerful and state-of-the-art methods for the efficient preparation of amines. It summarizes recent advances in the electrophilic amination reaction, hydroamination, C?H amination as well as newly developed photocatalytic approaches. It further describes organocatalytic and enzymatic routes to the generation of amines under mild and environmentally friendly conditions. In addition, it highlights the relevance of the amino function in bioactive molecules, drugs, and in the engineering of smart materials. Finally, the application of palladium-catalyzed aromatic amination in industrial context is critically discussed. Only up-to-date and comprehensive book on the preparation of amines ? one of the most frequently occurring compound classes found in natural products, bioactive molecules, and advanced materials. Presents efficient and useful synthetic methods, highlights opportunities / challenges as well as applications in pharmaceutical chemistry and materials science. Chapters are compiled by well-known experts in the field. One of them edited the previous books Modern Amination Methods (2001) and Amino Group Chemistry (2007). The book Methodologies in Amine Synthesis: Challenges and Applications is a musthave for chemists in academia and industry working in the field of organic synthesis and catalysis, natural product chemistry, drug synthesis and pharmaceutical chemistry, as well as materials science.
Author: Thomas C. Nugent
Publisher: John Wiley & Sons
ISBN: 9783527629558
Category : Science
Languages : en
Pages : 520
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Book Description
This first comprehensive presentation of this hot and important topic compiles the most up-to-date methods for chiral amine synthesis. The international list of authors reads like a "Who's Who" of the subject, providing a large array of highly practical information concentrated into the useful and essential methods. Following an introductory chapter devoted to helping readers quickly determine which strategies to choose for their investigation, this handbook and ready reference focuses on the examination of methods that are reliable and simultaneously efficient for the synthesis of structurally diverse aliphatic and aromatic chiral amines. Modern methods and applications found in (pharmaceutical) industry are also covered.
Author: Stephen A. Lawrence
Publisher: Cambridge University Press
ISBN: 9780521782845
Category : Science
Languages : en
Pages : 388
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Book Description
The understanding of amine chemistry is of paramount importance to numerous chemical industries, as well as academic research. This book provides an authoritative account of the properties and applications of amines with respect to the characteristics of bonded substituents and the nature of their surrounding chemical and physical environments. The synthesis of alkyl, aryl and heterocyclic amines and inorganic amines with a review of their typical reactions is comprehensively treated, whilst practical synthetic and analytical methods for laboratory preparation and detection are provided. The importance of amine chemistry from the nineteenth century to the modern day, with a brief history of the development of ammonia synthesis, is included.
Author: Feng Shi
Publisher: Academic Press
ISBN: 9780128122846
Category : Science
Languages : en
Pages : 0
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Book Description
Catalytic Amination for N-Alkyl Amine Synthesis provides a useful survey of this key type of reaction for chemistry researchers in academia and industry. Beginning with an introduction to amination and the development of the field, the book focuses on useful and high potential methods, such as the catalytic amination of alcohol with homogeneous and heterogeneous catalysts, the coupling reaction of olefin and amine, and the reductive amination of carbon dioxide with different reducing agents. The work also discusses two key examples of one-pot synthesis, the oxidative amination of alkane and amine and synthesis of N-alkyl amine with nitrobenzene and nitrile as starting materials. Valuable for chemists, materials scientists, chemical engineers and others, the book offers a unique overview of this growing area and its future possibilities.
Author: Gonzalo de Gonzalo
Publisher: John Wiley & Sons
ISBN: 352734683X
Category : Science
Languages : en
Pages : 54
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Book Description
This reference book originates from the interdisciplinary research cooperation between academia and industry. In three distinct parts, latest results from basic research on stable enzymes are explained and brought into context with possible industrial applications. Downstream processing technology as well as biocatalytic and biotechnological production processes from global players display the enormous potential of biocatalysts. Application of "extreme" reaction conditions (i.e. unconventional, such as high temperature, pressure, and pH value) - biocatalysts are normally used within a well defined process window - leads to novel synthetic effects. Both novel enzyme systems and the synthetic routes in which they can be applied are made accessible to the reader. In addition, the complementary innovative process technology under unconventional conditions is highlighted by latest examples from biotech industry.
Author: Feng Shi
Publisher: Academic Press
ISBN: 0128122854
Category : Technology & Engineering
Languages : en
Pages : 208
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Book Description
Catalytic Amination for N-Alkyl Amine Synthesis provides a useful survey of this key type of reaction for chemistry researchers in academia and industry. Beginning with an introduction to amination and the development of the field, the book focuses on useful and high potential methods, such as the catalytic amination of alcohol with homogeneous and heterogeneous catalysts, the coupling reaction of olefin and amine, and the reductive amination of carbon dioxide with different reducing agents. The work also discusses two key examples of one-pot synthesis, the oxidative amination of alkane and amine and synthesis of N-alkyl amine with nitrobenzene and nitrile as starting materials. Valuable for chemists, materials scientists, chemical engineers and others, the book offers a unique overview of this growing area and its future possibilities. Describes the catalytic amination of alcohol with homogeneous and heterogeneous catalysts Discusses the one-pot oxidative amination of alkane and amine Explores the application of ammonia as the N-source in amination reaction to avoid primary or secondary amine synthesis
Author: Qi Meng
Publisher: Open Dissertation Press
ISBN: 9781361333471
Category :
Languages : en
Pages :
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Book Description
This dissertation, "Amine synthesis using tandem aza-witting/imine reduction reactions" by Qi, Meng, 孟琪, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Nowadays, both secondary and tertiary amines are playing vital roles in modern chemical industry as well as pharmaceutical industry. Various synthetic methods of amines have also been reported due to their promising applications. In this thesis, a simple and widely applicable one-pot aza-Wittig/reduction method is reported for synthesizing both secondary and tertiary amines. Firstly, we focused on tandem aza-Wittig/reduction reactions for synthesizing secondary amines. We noticed that an aza-Wittig reaction involving an iminophosphrane which is the product from a Staudinger reaction, followed by addition of an aldehyde can be used to construct a C=N double bond in the product. By making use of the PPh3O (byproduct of aza-Wittig reactions) as the catalyst along with trichlorosilane as the reducing agent, the imine products in the aza-Wittig reactions can be converted into amines in one pot. In addition to using PPh3, highly-efficient heterogeneous polystyrene-based rasta resin-supported PPh3 was also examined in our study. Secondly, in order to broaden the utility of this one-pot method, instead of using relatively dangerous organic azides as substrates, in situ azide formation reaction was added to the flow chart. By reacting alkyl bromides with sodium azide or tertabutylammonium azide can give various azides in one-pot. Thirdly, the secondary amines formed using our one-pot procedure can undergo reductive amination reaction with aldehyde to give diverse tertiary amines as the final products in one pot. In this reaction, trichlorosilane reduction was performed twice by utilizing the phosphine oxide byproduct from the aza-Wittig reaction as a catalyst. Finally, chemistry regarding tandem one-pot aza-Wittig reaction by using catalytic amount of phosphine oxide was discussed. Instead of using organic azides, various aryl isocyanates were used as substrates for the reaction, with the help of catalytic amount of a five-membered ring phosphine oxide to give high yields of secondary amines. Chemistry studied in the thesis stands as solid proof for the superiority of our method. Tandem one-pot reactions improved the efficiency of our method by avoiding lengthy workup and purification steps. Our chemistry may serve as a good alternative for both secondary and tertiary amine synthesis in the future. DOI: 10.5353/th_b5177335 Subjects: Amines - Synthesis
![The Efficient Synthesis of [alpha]-chiral Amines PDF](https://books.google.com/books/content/images/frontcover/kqqhOgAACAAJ?fife=w80-h100)
Author: Vijay Narayan Wakchaure
Publisher:
ISBN:
Category :
Languages : en
Pages : 248
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Book Description
The importance of and the methods for preparing [alpha]-chiral amines are described in chapter 1. The two main strategies 'hydrogen' addition vs carbanion addition have had significant impact for the synthesis of [alpha]-chiral amines. Comparison of the literature pertaining to these two different approaches shows them to generally be complementary. From this perspective, the main goal of the described research in this thesis was to develop improved methodology for the preparation of enantiomerically pure [alpha]-chiral amines based on asymmetric reductive amination and carbanion addition methods. Chapter 2 describes a two-step procedure for [alpha]-chiral primary amine synthesis based on reductive amination. The first and key step is the asymmetric reductive amination of a prochiral ketone with a-methylbenzylamine (a-MBA). Depending on the ketone examined, the correct combination of heterogeneous hydrogenation catalyst, solvent, and temperature is crucial for allowing high yield and de with practical reaction times under hydrogenation. Chapter 3 describes the first ytterbium promoted reductive amination reaction which shows significantly enhanced diastereoselectivity as compared to all previous methods. Furthermore, an advantage of this new Lewis acid based reductive amination procedure, verses the traditional Brønsted based methods is the suppression of alcohol by-product formation, is discussed in this chapter. A one-pot asymmetric sequential amination-alkylation (carbanion addition to in situ formed aldimine) method for the synthesis of alkyl-alkyl' [alpha]-chiral primary amines from aldehydes is described in the chapter 4. In situ aldimine formation from aliphatic aldehydes with (R)- or (S)-[alpha]-MBA [catalyzed by 5 mol-% Ti(OiPr)4] followed by reaction with a methyl, ethyl, or n-butyl cuprate complex, in the presence of boron trifluoride, provides good yield and diastereomeric excess.
Author: Alfredo Ricci
Publisher: John Wiley & Sons
ISBN: 3527613196
Category : Science
Languages : en
Pages : 285
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Book Description
Organic compounds containing amino groups are at the center of modern organic chemistry, and are widely used in the pharmaceutical industry, crop protection, natural product chemistry, and in advanced materials. Modern methods for the introduction of the amino group are therefore of major importance to synthetic chemists and product developers. Over the last decade, many methods have been developed to generate new C-N bonds. At the same time, the pharmaceutical and chemical industry was rapidly moving away from the development of racemic compounds to the direct synthesis of enantiomerically pure materials. The articles of this book, written by internationally recognized experts, thus focus on asymmetric synthesis. The most recent catalytic amination methods have particularly revolutionized the chemistry of amino compounds - and you find them all in this first comprehensive overview.
