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Author: Pratish Gawand
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Pratish Gawand
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Jens Nielsen
Publisher: Springer
ISBN: 3540453008
Category : Science
Languages : en
Pages : 193
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Book Description
Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.
Author: Sang Yup Lee
Publisher: John Wiley & Sons
ISBN: 352782345X
Category : Science
Languages : en
Pages : 1075
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Book Description
Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
Author: Wenfa Ng
Publisher:
ISBN: 9781685075552
Category : Science
Languages : en
Pages : 0
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Book Description
Metabolic engineering and biocatalysis aim to produce new value-added products from biological routes through careful and deliberate genetic engineering in different microbial chassis with suitable metabolic repertoire. Hitherto, the endeavor has largely been confined to the production of new products from glucose and a few other well characterized substrates. But, as the bioeconomy gains in importance and the world seeks to explore new sources of carbon as feedstocks, a possibility exists in developing alternative C2 compounds as feedstocks in contrast to the current reliance on C6 (glucose and fructose), C5 (xylose) and C3 (glycerol) substrates. Two potential C2 alternative substrates explored in this work are ethanol and ethylene glycol. Ethanol is a biofuel whose biotechnological potential has not been fully explored. In the first part of the book, the potential of using the NADH generated from a reconstructed ethanol utilization pathway to power a biotransformation reaction is explored in Escherichia coli. Experimental results indicate that ethanol utilization delivers higher biotransformation efficiency compared to state-of-the-art glucose dehydrogenase system, which confirmed theoretical predictions of relative efficiency of the two systems. Next, the book switches attention to ethylene glycol which could be derived as breakdown products of lignocellulosic waste or from plastic waste. Here, the proposal is to demonstrate the potential of an NADH generating ethylene glycol utilization pathway that terminates at glycolate to support biocatalytic reactions in E. coli. Subsequently, the two-step ethylene glycol utilization pathway would be extended to malate and 2-phosphoglycerate to help another biotechnology workhorse, Bacillus subtilis, to grow on ethylene glycol as the sole carbon source. Different connection points to central carbon metabolism would provide a natural experiment to decipher the relative efficiencies of activating tricarboxylic acid cycle and glycolysis in supporting cell growth, and illuminate insights into the relative efficiency and evolutionary importance of different branches of metabolism in B. subtilis. Finally, ethylene glycol utilization would be combined with product formation to help B. subtilis to synthesize green fluorescent protein using flux from the C2 alternative substrate. This system would provide a platform for examining the efficacy of different ethylene glycol utilization pathways and entry points in central carbon metabolism in synthesizing amino acids and proteins. Overall, this book hopes to explore the biotechnological potential of two alternative C2 substrates (ethanol and ethylene glycol) in biocatalysis and metabolic engineering from the substrate utilization perspective.
Author: Michael E. Himmel
Publisher: Humana
ISBN: 9781071601945
Category : Medical
Languages : en
Pages : 0
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Book Description
This book illustrates experimental and computational methodologies used to achieve cost effective biological processes for the production of fuels and biochemicals through multiple approaches to increasing yield, titers, and productivity in a robust host. The volume includes the most recent and cutting-edge aspects of pathway engineering, flux analysis, and metabolic enzyme engineering. Each chapter highlights the complexity and challenges of the problem as well as the methods used to solve this problem or changes needed in current methods. As a part of the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that gives researchers a much needed boost. Authoritative and practical, Metabolic Pathway Engineering benefits not only scientists working on more fundamental aspects of this endeavor but also those in the biochemical industry working on strain engineering for robust industrial processes.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309219396
Category : Science
Languages : en
Pages : 570
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Book Description
Many potential applications of synthetic and systems biology are relevant to the challenges associated with the detection, surveillance, and responses to emerging and re-emerging infectious diseases. On March 14 and 15, 2011, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to explore the current state of the science of synthetic biology, including its dependency on systems biology; discussed the different approaches that scientists are taking to engineer, or reengineer, biological systems; and discussed how the tools and approaches of synthetic and systems biology were being applied to mitigate the risks associated with emerging infectious diseases. The Science and Applications of Synthetic and Systems Biology is organized into sections as a topic-by-topic distillation of the presentations and discussions that took place at the workshop. Its purpose is to present information from relevant experience, to delineate a range of pivotal issues and their respective challenges, and to offer differing perspectives on the topic as discussed and described by the workshop participants. This report also includes a collection of individually authored papers and commentary.
Author: Sonia Cortassa
Publisher: World Scientific
ISBN: 9789810248369
Category : Science
Languages : en
Pages : 270
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Book Description
Metabolic and cellular engineering is a powerful alliance of two technologies: genetics-molecular biology and fermentation technology.
Author: Christoph Wittmann
Publisher: Springer Science & Business Media
ISBN: 9400745346
Category : Medical
Languages : en
Pages : 391
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Book Description
Systems Metabolic Engineering is changing the way microbial cell factories are designed and optimized for industrial production. Integrating systems biology and biotechnology with new concepts from synthetic biology enables the global analysis and engineering of microorganisms and bioprocesses at super efficiency and versatility otherwise not accessible. Without doubt, systems metabolic engineering is a major driver towards bio-based production of chemicals, materials and fuels from renewables and thus one of the core technologies of global green growth. In this book, Christoph Wittmann and Sang-Yup Lee have assembled the world leaders on systems metabolic engineering and cover the full story – from genomes and networks via discovery and design to industrial implementation practises. This book is a comprehensive resource for students and researchers from academia and industry interested in systems metabolic engineering. It provides us with the fundaments to targeted engineering of microbial cells for sustainable bio-production and stimulates those who are interested to enter this exiting research field.
Author: Christoph Wittmann
Publisher: John Wiley & Sons
ISBN: 3527341811
Category : Science
Languages : en
Pages : 642
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Book Description
The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries.
Author: Vijai Singh
Publisher: Springer Nature
ISBN: 9811526044
Category : Medical
Languages : en
Pages : 326
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Book Description
This book provides a comprehensive overview of the basic and advanced metabolic engineering technologies used to generate natural metabolites and industrially important biomolecules. Metabolic engineering has the potential to produce large quantities of valuable biomolecules in a renewable and sustainable manner by extending or modifying biosynthetic pathways in a wide range of organisms. It has been successfully used to produce chemicals, drugs, enzymes, amino acids, antibiotics, biofuels, and industrially important pharmaceuticals. The book comprehensively reviews the various metabolites detection, extraction and biosensors and the metabolic engineering of microbial strains for the production of industrially useful enzymes, proteins, organic acids, vitamins and antibiotics, therapeutics, chemicals, and biofuels. It also discusses various genetic engineering and synthetic biology tools for metabolic engineering. In closing, the book discusses ethical, patenting and regulatory issues in the metabolic engineering of microbes. This book is a valuable source not only for beginners in metabolic engineering, but also students, researchers, biotechnology and metabolic engineering based company.
