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Author: V. Srinivasan
Publisher: Springer Science & Business Media
ISBN: 8132208250
Category : Medical
Languages : en
Pages : 405
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Book Description
The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson’s disease, Alzheimer’s disease. Additionally, melatonin’s therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin’s antioxidant role in Duchenne’s muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.
Author: V. Srinivasan
Publisher: Springer Science & Business Media
ISBN: 8132208250
Category : Medical
Languages : en
Pages : 405
Get Book Here
Book Description
The book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson’s disease, Alzheimer’s disease. Additionally, melatonin’s therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin’s antioxidant role in Duchenne’s muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.
Author: Francisco López-Muñoz
Publisher: Springer
ISBN: 8132228030
Category : Medical
Languages : en
Pages : 917
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Book Description
This work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .
Author: Venkatramanujan Srinivasan
Publisher: CRC Press
ISBN: 1482220091
Category : Medical
Languages : en
Pages : 576
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Book Description
There is growing interest in the field of melatonin research regarding its neurobiological mechanisms as well as its repercussions in clinical practice. Melatonin: Therapeutic Value and Neuroprotection explores melatonin’s neuroprotective effects and discusses the therapeutic potential of melatonin and melatonin agonists in treating neurodegenerative diseases and other ailments. Topics include: The basic aspects of melatonin’s physiology, including its production, bioavailability, and metabolism The functional importance of melatonin receptors and their role in mediating the therapeutic effectiveness of melatonin in cancer Melatonin’s effect on the regulation of blood pressure, sleep, and circadian rhythms The cardioprotective role of melatonin The neuroprotective role in glaucoma, Alzheimer’s disease, Parkinson’s disease, and neurodegenerative diseases Use as a therapeutic agent for treating epilepsy and degenerative discs Treatment for obesity, diabetes mellitus, and other metabolic disorders Protective role in peri-natal hypoxic-ischemia The contributors also examine the discovery of a number of melatonergic agonists, their potential role as antioxidants, and their therapeutic applications in treating glaucoma, Parkinson’s disease, Alzheimer’s disease, primary insomnia, and psychiatric disorders. Opening new vistas in our understanding of etiology, pharmacotherapy, and treatment, the book is a significant milestone in our knowledge about advances in melatonin’s physiology and its therapeutic application in a number of disorders.
Author: Cristina Manuela Drăgoi
Publisher: BoD – Books on Demand
ISBN: 1789845041
Category : Medical
Languages : en
Pages : 211
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Book Description
Melatonin, the pineal neurohormone, is a pleiotropic molecule acting in the center of the integrative molecular mechanisms of the organism, based on interconnections of the regulatory systems: neural, endocrine, immune, and genetic, conveying into the uniqueness of human architecture. This book provides a systematic and updated overview of melatonin biochemical mechanisms of action, pharmacological features, and clinical uses, clutching the subject with complete details of pharmaceutical formulations designed for different routes of administration and different health issues, aiming at optimal melatonin bioavailability when therapeutically delivered. The book addresses a broad range of audiences, from healthcare professionals, medically and pharmaceutically based, to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge of the physiological and pathological implications of melatonin and its metabolites.
Author: Richard Hansler
Publisher: Richard Hansler
ISBN: 057874337X
Category : Medical
Languages : en
Pages : 58
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Book Description
The first reaction to covid-19 was to stay at home to avoid rapid spread. Now people are venturing out and are looking for ways to reduce the risk. Wearing masks, social distancing, washing hands, all help. This book offers another way: Maximizing natural melatonin and taking melatonin by mouth. We examine the evidence that melatonin may increase immunity to the virus as it does in young children who make large amounts of natural melatonin. It may also reduce the severity of the infection. Exposing the eyes to light in the hours before bedtime stops the body from making melatonin. Wearing orange glasses allows production of melatonin. Go to our for glasses. Wearing the glasses for 3 - 4 hours before a 7 to 8 hour sleep in darkness will maximize natural melatonin. Taking a 2 - 5mg melatonin tablet when you put on the glasses will avoid disturbing your circadian rhythm. Natural melatonin is injected directly into the brain where it can protect the brain from the virus. Melatonin has been shown to be very safe, even in very larger doses. Dr. Hansler, the author, did research for GE Lighting for 43 years before retiring to John Carroll University where he studied the effect of light on sleep and health. He has written 9 other books about this.
Author: Gerald Huether
Publisher: Springer Science & Business Media
ISBN: 1461547091
Category : Medical
Languages : en
Pages : 824
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Book Description
This volume contains the proceedings of the Ninth Meeting of the "International Study Group for Tryptophan Research" (lSTRY), held at the University of Hamburg, Germany, from October 10 to 14, 1998. At this meeting the recent developments in the field of tryptophan research were presented by leading researchers from all over the world in 81 oral and 48 poster contri butions. Research on tryptophan and its derivatives provides an inexhaustible subject. At the conference we tried to compose a multifacetted picture of the recent investiga tions through contributions from the major disciplines involved. Thus, we tried to strike a balance between basic research topics and clinical, nutritional or industrial applica tions. We offered workshops on tryptophan (in sleep and mood), melatonjn, IDO-acti vation and the eosinophilia-myalgia syndrome (EMS) as a platform for intensive discussion for the participants. In these proceedings many contributions are multidisciplinary and have practical or theoretical implications for different research fields. Hence, we have organized this volume in nine main chapters according to basic disciplines and subjects. We are aware that this classification is artificial, but we hope that it is the best compromise for contributors and readers.
Author: S. R. Pandi-Perumal
Publisher: CRC Press
ISBN: 9780415438186
Category : Medical
Languages : en
Pages : 0
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Book Description
One of the first such volumes in this field, Sleep Disorders: Diagnosis and Therapeutics explores sleep pharmacology and therapeutics. Leading researchers in the area of experimental and clinical and psychopharmacology critically assess the progress in their specialist fields. The book is suitable as an introduction for clinicians and researchers who are new to sleep pharmacology and outlines the wider range of therapeutic options currently available to them. For seasoned clinicians, the book will assist in selecting the most appropriate methodologies and treatment options designed to circumvent the problems in combating sleep disorders.
Author: J. John Mann
Publisher: Cambridge University Press
ISBN: 1107024633
Category : Medical
Languages : en
Pages : 429
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Book Description
Provides a one-stop evidence-based guide to the management of all types of mood disorders.
Author:
Publisher: Elsevier
ISBN: 0128211091
Category : Psychology
Languages : en
Pages : 442
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Book Description
Update on Emerging Treatments for Migraine, Volume 255, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Progress in Brain Research series - Updated release includes the latest information on Update on Emerging Treatments for Migraine
Author: P. H. Redfern
Publisher: Pharmaceutical Press
ISBN: 9780853694885
Category : Biological rhythms
Languages : en
Pages : 456
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Book Description
In nature, many physical processes are governed by the passage of time. The study of these processes - chronobiology - reveals rhythmic patterns which may be yearly, monthly, daily or more frequent. Novel drug delivery systems are currently being delivered that will release varying quantities of a drug at optimum times to coincide with these rhythmic patterns.Chronotherapeutics considers the pharmaceutical and therapeutic implications associated with biological clocks. The book presents a comprehensive discussion of specific diseases that are time dependent, and the drugs and new drug formulations that can be used as treatments.Written by leading international experts in the field, Chronotherapeutics provides up-to-date information on chronobiology for non-chronobiologists in pharmaceutical and medical sciences. Peter Redfern is Professor of Pharmacology at the University of Bath, UK.
