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Author: Garden Grove Garden Grove Press
Publisher:
ISBN: 9781544932149
Category :
Languages : en
Pages : 168
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Book Description
This article collection reviews the medical genetics of endometrial cancer and includes 20 papers by various authors. Topics include: Genetic variants in MUTYH are not associated with endometrial cancer risk; Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium; Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families; Genetic testing in a gynaecological oncology care in developing countries - knowledge, attitudes and perception of Nepalese clinicians; New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care; PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study; Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk; Genetic variations of MUC17 are associated with endometriosis development and related infertility; Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma; Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer; Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach; Potential contribution of the uterine microbiome in the development of endometrial cancer; The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor; Common mitochondrial polymorphisms as risk factor for endometrial cancer; Identification of subgroup-specific miRNA patterns by epigenetic profiling of sporadic and Lynch syndrome-associated colorectal and endometrial carcinoma; Immunotherapy in endometrial cancer - an evolving therapeutic paradigm; HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study; Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome; Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing - a case report; The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer. Proceeds from the sale of this book go to the support of an elderly disabled person.
Author: Garden Grove Garden Grove Press
Publisher:
ISBN: 9781544932149
Category :
Languages : en
Pages : 168
Get Book
Book Description
This article collection reviews the medical genetics of endometrial cancer and includes 20 papers by various authors. Topics include: Genetic variants in MUTYH are not associated with endometrial cancer risk; Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium; Management of ovarian and endometrial cancers in women belonging to HNPCC carrier families: review of the literature and results of cancer risk assessment in Polish HNPCC families; Genetic testing in a gynaecological oncology care in developing countries - knowledge, attitudes and perception of Nepalese clinicians; New classification of endometrial cancers: the development and potential applications of genomic-based classification in research and clinical care; PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study; Toll-Like Receptor (TLR) and Nucleosome-binding Oligomerization Domain (NOD) gene polymorphisms and endometrial cancer risk; Genetic variations of MUC17 are associated with endometriosis development and related infertility; Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma; Two novel sequence variants in MSH2 gene in a patient who underwent cancer genetic counseling for a very early-onset epithelial ovarian cancer; Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach; Potential contribution of the uterine microbiome in the development of endometrial cancer; The influence of the Cyclin D1 870 G>A polymorphism as an endometrial cancer risk factor; Common mitochondrial polymorphisms as risk factor for endometrial cancer; Identification of subgroup-specific miRNA patterns by epigenetic profiling of sporadic and Lynch syndrome-associated colorectal and endometrial carcinoma; Immunotherapy in endometrial cancer - an evolving therapeutic paradigm; HNF1B polymorphism influences the prognosis of endometrial cancer patients: a cohort study; Molecular characteristics of endometrial cancer coexisting with peritoneal malignant mesothelioma in Li-Fraumeni-like syndrome; Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing - a case report; The impact of microRNA-mediated PI3K/AKT signaling on epithelial-mesenchymal transition and cancer stemness in endometrial cancer. Proceeds from the sale of this book go to the support of an elderly disabled person.
Author: Lora Hedrick Ellenson
Publisher: Springer
ISBN: 3319431390
Category : Medical
Languages : en
Pages : 281
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Book Description
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Author: Mansoor R. Mirza
Publisher: Springer
ISBN: 3319645137
Category : Medical
Languages : en
Pages : 324
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Book Description
This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.
Author: Eric J. Bieber
Publisher: Cambridge University Press
ISBN: 1107040396
Category : Medical
Languages : en
Pages : 1127
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Book Description
Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.
Author: Sue Clark,
Publisher: tfm Publishing Limited
ISBN: 1908986336
Category : Medical
Languages : en
Pages : 257
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Book Description
FIRST PRIZE Winner in the Oncology category of the 2010 BMA Medical Book Competition. Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognized, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined. This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other subspecialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions.
Author: Chris Jacobs
Publisher: Oxford University Press, USA
ISBN: 0199672849
Category : Medical
Languages : en
Pages : 363
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Book Description
This title equips health professionals with the knowledge and skills required for all aspects of managing cancer family history, discussing the challenges raised and providing practical guidance on setting up a cancer family history clinic in primary and secondary care.
Author: Michael T. Deavers
Publisher: Springer
ISBN: 3319579851
Category : Medical
Languages : en
Pages : 286
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Book Description
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
Author: Karen H. Lu
Publisher: CRC Press
ISBN: 9781420052879
Category : Medical
Languages : en
Pages : 0
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Book Description
Hereditary Gynecologic Cancer: Risk, Prevention and Management fills the need that exists for a book addressing highly relevant clinical issues associated with the new field of hereditary gynecologic cancers. Written with the clinician in mind, the authors will cover a broad range of topics, beginning with an overview discussing clinical relevance of hereditary ovarian and hereditary endometrial cancers. Succeeding sections will provide in-depth analyses of Hereditary Breast Ovarian Cancer Syndrome, Lynch Syndrome, and other syndromes with gynecologic cancer components, and genetic risk assessment. Hereditary Gynecologic Cancer: Risk, Prevention and Management: is the first clinically focused reference detailing gynecologic patient management issues of BRCA1 and BRCA2 mutation carriers includes a practical section on genetic risk assessment and genetic testing examines case studies to demonstrate management techniques and decision-making provides detailed discussion of ovarian cancer screening, prevention and risk reducing surgery
Author: Arlan F. Fuller
Publisher: PMPH-USA
ISBN: 9781550091632
Category : CD-ROMs
Languages : en
Pages : 248
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Book Description
Presents an overview of the most frequently diagnosed gynecologic malignancy, endometrial carcinoma, as well as a collection of mesenchymal tumors. Reviews epidemiology, genetics, diagnosis, staging, prognosis, treatment, postsurgical management, and pathologic evaluation.
Author: Laura Valle
Publisher: Springer
ISBN: 3319742590
Category : Medical
Languages : en
Pages : 505
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Book Description
This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.
