Author: James Lee Sung
Publisher:
ISBN:
Category :
Languages : en
Pages : 78
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Book Description
Prostate is cancer is the most commonly diagnosed cancer in men worldwide and the second biggest killer among cancer related deaths in men. Due to advances in both detection as well as treatment, the disease can often be caught early when it is still confined within the prostate gland. The prognosis of patients when the disease is still confined within the organ is generally good. However, the prognosis in patients when the disease has spread to regional lymph nodes is very poor. Metastatic prostate cancer accounts for nearly all the mortality associated with prostate cancer. Numerous clinical studies have documented the importance of lymph node involvement in predicting patient survival. These data suggest that not only is lymph node involvement an important indicator of systemic metastases, they may be an active participant in the process. In the present report, we provide insight into mechanisms that are involved in prostate cancer metastasis to lymph nodes. First, we examine the relationship between the lymphangiogenic mechanisms and prostate dissemination to lymph nodes. Second we, offer insight into lymph node specific homing mechanisms used by prostate cancer cells. Finally, we describe a strategy to interrogate the significance of lymph nodes as a reservoir of malignant cells that can fuel future metastatic dissemination. A better understanding of the mechanisms involved in lymph node metastasis will allow us to better treat the metastatic disease.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 4
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Book Description
Author: Yiping Zeng
Publisher:
ISBN:
Category : Lymph nodes
Languages : en
Pages : 568
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 24
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Book Description
Metastatic spread of prostate cancer is the second leading cause of deaths of men in theUnited States. Although there are many ways to treat non-metastatic form of prostate cancer, only androgen-deprivation therapy is available for the extensive stage. Again, the cancerwill often progress to an androgen refractory (independent), metastatic stage. Recent reportshave suggested that the expression of VEGF-C and its receptor VEGFR-3 are directly correlatedwith lymph node dissemination in prostate cancer. This finding leads us to think thatunderstanding the role of angiogenic molecules like VEGF-C, -D in molecular detail forlymphatic formation in prostate cancer will provide us the information regarding theirrelationship with lymph node metastasis. We have observed significant increase in reactiveoxygen species and activation of small GTPase RalA upon androgen withdrawal, which in turnupregulates VEGF-C in prostate cancer cells. Interestingly our results suggest a function ofVEGF-C, which is directly related to its role in increasing the metastatic propensity ofprostate cancer rather than inducing lymphangiogenesis.
Author: Stanley P. Leong
Publisher: Springer
ISBN: 9783030930837
Category : Medical
Languages : en
Pages : 0
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Book Description
This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.
Author: Manfred Wirth
Publisher: Walter de Gruyter
ISBN: 3110807270
Category : Medical
Languages : en
Pages : 220
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Book Description
Author: L.A. Liotta
Publisher: Springer Science & Business Media
ISBN: 9400975112
Category : Medical
Languages : en
Pages : 544
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Book Description
The clinical significance of tumor spread has always been appreciated. Yet, in spite of the pioneering work and outstanding contributions of investigators such as D. Coman, H. Green, B. Fisher, S. Wood and I. Zeidman, studies on metastasis rarely achieved the popularity afforded to more esoteric areas of tumor biology. Tumor dissemination, occurring as it does in a responding host and being composed of a series of dynamic int~ractions, is a highly complex phenomenon. Few investigators were brave enough to attempt to unravel the mechanisms involved. Paradoxically, this very complexity may have contributed, in part, to the recent upsurge of interest in metastasis research. More and more researchers are becoming fascinated by the complexities of the cellular interactions involved in tumor spread. Accompanying this intellectual stimulation have been technological advances in related fields which allow the derivation of new model systems. The mechanisms of metastatic spread are increasingly amenable to both the reductionist and holistic approaches and it is the purpose of this volume to present many of these model systems while emphasizing the intricacy and complexity of the processes they mimic. We have attempted to emphasize two topics not previously covered in depth in previous books on metastases. These are in vitro models of invasion and in teractions of tumor cells with connective tissue.
Author: William J. LaRochelle
Publisher: Springer Science & Business Media
ISBN: 1592598935
Category : Medical
Languages : en
Pages : 745
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Book Description
An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Author: Leonard Weiss
Publisher: Macmillan Reference USA
ISBN:
Category : Medical
Languages : en
Pages : 362
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Book Description
Author: Giuliano Mariani
Publisher: Springer Science & Business Media
ISBN: 8847027667
Category : Medical
Languages : en
Pages : 306
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Book Description
Although lymphoscintigraphy was originally introduced into clinical routine for identification of the cause of peripheral edema, more recently it has been widely applied for radioguided biopsy of the sentinel lymph node in patients with solid cancers. The procedure is now considered crucial for adequate planning of oncologic surgery in a growing number of cancers. This atlas presents a collection of richly illustrated teaching cases that demonstrate the clinical relevance and impact of lymphoscintigraphy in different pathologic conditions. After introductory chapters on the anatomy, physiology, and pathophysiology of lymphatic circulation, the role of lymphoscintigraphy in differential diagnosis of peripheral edema and characterization of intracavitary lymph effusions is addressed. The principal focus of the book, however, is on the use of lymphoscintigraphic mapping for radioguided sentinel node biopsy in cutaneous melanoma and cancers at a range of anatomic sites. The most commonly observed lymphoscintigraphic patterns are depicted, and anatomic variants and technical pitfalls of the procedure receive careful attention. The role of tomographic multimodality imaging is also considered. The atlas will be an excellent learning tool for residents in nuclear medicine and other specialists with an interest in the field.
