Novel Molecular Targets for the Treatment of Pain PDF Download
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Author: Tally Largent-Milnes
Publisher: Frontiers Media SA
ISBN: 2889664422
Category : Science
Languages : en
Pages : 164
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Book Description
Topic Editor John Streicher is a co-founder and equity partner of Teleport Pharmaceuticals, LLC. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Author: Tally Largent-Milnes
Publisher: Frontiers Media SA
ISBN: 2889664422
Category : Science
Languages : en
Pages : 164
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Book Description
Topic Editor John Streicher is a co-founder and equity partner of Teleport Pharmaceuticals, LLC. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Author: Milica S. Prostran
Publisher: Frontiers Media SA
ISBN: 2889639479
Category : Science
Languages : en
Pages : 297
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Book Description
Acute pain has a physiological protective role in preventing tissue damage. However, pain can become chronic due to a multitude of pathophysiological states, such as: trauma, inflammation, neural injury, viral infection, cancer, autoimmune diseases and vascular and metabolic disorders. These pathological states can trigger alterations of the pain pathways that can lead to hypersensitivity, and in such circumstances, pain loses its protective role and instead, becomes persistent and debilitating affecting seriously to the quality of life of patients. Chronic pain is one of the most important health problems worldwide. It has been estimated that 10% of adults are diagnosed with chronic pain each year. However, despite the high prevalence of chronic pain, its management is still no fully satisfactory probably due to the variety of chronic pain conditions with different etiologies (neuropathic, visceral and musculoskeletal pain), and because their pathophysiological mechanisms are only partially known. Therefore, there is a huge need for new effective therapies for the control and/or prevention of the different types of chronic pain. Chronic pain is associated with plastic changes in pain circuits of the peripheral and central nervous system, including changes in the expression of ion channels, neurotransmitters and receptors. In addition, there is growing consensus on non-neuronal mechanisms that can amplify or resolve chronic pain, and cells traditionally thought to act just as coordinators of the inflammatory response (such as immune and glial cells) are now accepted as real modulators of pain signaling. In this regard, animal models of persistent pain, such as models of neuropathic and visceral pain and models of arthritis, are helping to elucidate our understanding of the pathogenesis of chronic pain and make it possible to test experimental treatments.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 030921484X
Category : Medical
Languages : en
Pages : 383
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Book Description
Chronic pain costs the nation up to $635 billion each year in medical treatment and lost productivity. The 2010 Patient Protection and Affordable Care Act required the Department of Health and Human Services (HHS) to enlist the Institute of Medicine (IOM) in examining pain as a public health problem. In this report, the IOM offers a blueprint for action in transforming prevention, care, education, and research, with the goal of providing relief for people with pain in America. To reach the vast multitude of people with various types of pain, the nation must adopt a population-level prevention and management strategy. The IOM recommends that HHS develop a comprehensive plan with specific goals, actions, and timeframes. Better data are needed to help shape efforts, especially on the groups of people currently underdiagnosed and undertreated, and the IOM encourages federal and state agencies and private organizations to accelerate the collection of data on pain incidence, prevalence, and treatments. Because pain varies from patient to patient, healthcare providers should increasingly aim at tailoring pain care to each person's experience, and self-management of pain should be promoted. In addition, because there are major gaps in knowledge about pain across health care and society alike, the IOM recommends that federal agencies and other stakeholders redesign education programs to bridge these gaps. Pain is a major driver for visits to physicians, a major reason for taking medications, a major cause of disability, and a key factor in quality of life and productivity. Given the burden of pain in human lives, dollars, and social consequences, relieving pain should be a national priority.
Author: Robert Fitridge
Publisher: University of Adelaide Press
ISBN: 1922064009
Category : Medical
Languages : en
Pages : 589
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Book Description
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author: Raymond S. Sinatra
Publisher: Cambridge University Press
ISBN: 0521874912
Category : Medical
Languages : en
Pages : 729
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Book Description
This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Author: Sanjog Pangarkar
Publisher: Elsevier Health Sciences
ISBN: 0323722172
Category : Medical
Languages : en
Pages : 296
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Book Description
Covering the newest trends and treatments in pain care, as well as the pain treatment strategies that have been successfully employed in the past, Pain Care Essentials and Innovations brings you fully up to date with effective treatments for acute and chronic pain. It offers expert guidance on both interventional and non-interventional strategies, provided by respected academic physiatrists who practice evidence-based medicine at UCLA and an ACGME-accredited rehabilitation and pain program. - Covers cannabinoids in pain care, novel therapeutics in pain medicine, and integrative care in pain management. - Discusses relevant basic science, psychological aspects of pain care, opioids and practice guidelines, geriatric pain management, and future research in the field. - Consolidates today's available information and guidance into a single, convenient resource.
Author: Michael H. Ebert
Publisher: Cambridge University Press
ISBN: 113949354X
Category : Medical
Languages : en
Pages : 507
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Book Description
Pain is the most common symptom bringing a patient to a physician's attention. Physicians training in pain medicine may originate from different disciplines and approach the field with varying backgrounds and experience. This book captures the theory and evidence-based practice of behavioral, psychotherapeutic and psychopharmacological treatments in modern pain medicine. The book's contributors span the fields of psychiatry, psychology, anesthesia, neurology, physical medicine and rehabilitation, and nursing. Thus the structure and content of the book convey the interdisciplinary approach that is the current standard for the successful practice of pain management. The book is designed to be used as a text for training fellowships in pain medicine, as well as graduate courses in psychology, nursing, and other health professions.
Author: Human Rights Watch (Organization)
Publisher: Human Rights Watch
ISBN: 1564324494
Category : Health & Fitness
Languages : en
Pages : 51
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Book Description
With support from the Open Society Institute International Palliative Care Initiative, Human Rights Watch released a groundbreaking report on the lack of access to pain relief medicines for millions of patients worldwide. The report, "Please Don't Make Us Suffer Anymore": Access to Pain Treatment as a Human Right, finds that countries can significantly improve access to pain medications by addressing the causes of their poor availability, which include the following: *Failure to put in place functioning supply and distribution systems *Absence of government policies to ensure medicine availability *Insufficient instruction for health care workers *Excessively strict drug-control regulations *Fear of legal sanctions among healthcare workers. "Please Don't Make Us Suffer Anymore" notes that international law requires states to make narcotic drugs available for the treatment of pain while preventing abuse, but that the strong international focus on preventing abuse of such drugs has led many countries to neglect that obligation. The full report is available in PDF format. French, Russian, and Spanish versions are available on the HRW website.
Author: Samir K. Ballas
Publisher: Lippincott Williams & Wilkins
ISBN: 1496331834
Category : Medical
Languages : en
Pages : 1004
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Book Description
Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain’s scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309490944
Category : Medical
Languages : en
Pages : 139
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Book Description
Pain is a leading cause of disability globally. The dramatic increase in opioid prescriptions within the past decade in the United States has contributed to the opioid epidemic the country currently faces, magnifying the need for longer term solutions to treat pain. The substantial burden of pain and the ongoing opioid crisis have attracted increased attention in medical and public policy communities, resulting in a revolution in thinking about how pain is managed. This new thinking acknowledges the complexity and biopsychosocial nature of the pain experience and the need for multifaceted pain management approaches with both pharmacological and nonpharmacological therapies. The magnitude and urgency of the twin problems of chronic pain and opioid addiction, combined with the changing landscape of pain management, prompted the National Academies of Sciences, Engineering, and Medicine to convene a workshop on December 4â€"5, 2018, in Washington, DC. The workshop brought together a diverse group of stakeholders to discuss the current status of nonpharmacological approaches to pain management, gaps, and future directions. This publication summarizes the presentations and discussions from the workshop.
