Measuring the Optical Properties of Human Muscle Tissue Using Time-of-flight Spectroscopy in the Near Infrared PDF Download
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Author: Staffan Strömblad
Publisher:
ISBN:
Category :
Languages : en
Pages : 45
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Author: Staffan Strömblad
Publisher:
ISBN:
Category :
Languages : en
Pages : 45
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Author: Yoko Hoshi
Publisher: MDPI
ISBN: 3039361007
Category : Science
Languages : en
Pages : 246
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Book Description
Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer–Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.
Author: Pieter Van der Zee
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Alfi Shaharin
Publisher:
ISBN:
Category :
Languages : en
Pages : 45
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Author: Thomas Jue
Publisher: Springer Science & Business Media
ISBN: 1461462525
Category : Medical
Languages : en
Pages : 156
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Book Description
In keeping with the style of the Handbook of Modern Biophysics, this fourth volume, Application of Near-Infrared Spectroscopy in Biomedicine, balances the need for physical science/mathematics formalism with a demand for biomedical perspectives. Each chapter divides the presentation into two major parts: the first establishes the conceptual framework and describes the instrumentation or technique, while the second illustrates current applications in addressing complex biology questions. With the additional sections on further reading, problems, and references, the interested reader can explore some chapter ideas more widely.
Author: Valery V. Tuchin
Publisher: CRC Press
ISBN: 1000466302
Category : Science
Languages : en
Pages : 682
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Book Description
Biomedical photonics is currently one of the fastest growing fields, connecting research in physics, optics, and electrical engineering coupled with medical and biological applications. It allows for the structural and functional analysis of tissues and cells with resolution and contrast unattainable by any other methods. However, the major challenges of many biophotonics techniques are associated with the need to enhance imaging resolution even further to the sub-cellular level as well as translate them for in vivo studies. The tissue optical clearing method uses immersion of tissues into optical clearing agents (OCAs) that reduces the scattering of tissue and makes tissue more transparent and this method has been successfully used ever since. This book is a self-contained introduction to tissue optical clearing, including the basic principles and in vitro biological applications, from in vitro to in vivo tissue optical clearing methods, and combination of tissue optical clearing and various optical imaging for diagnosis. The chapters cover a wide range of issues related to the field of tissue optical clearing: mechanisms of tissue optical clearing in vitro and in vivo; traditional and innovative optical clearing agents; recent achievements in optical clearing of different tissues (including pathological tissues) and blood for optical imaging diagnosis and therapy. This book provides a comprehensive account of the latest research and possibilities of utilising optical clearing as an instrument for improving the diagnostic effectiveness of modern optical diagnostic methods. The book is addressed to biophysicist researchers, graduate students and postdocs of biomedical specialties, as well as biomedical engineers and physicians interested in the development and application of optical methods in medicine. Key features: The first collective reference to collate all known knowledge on this topic Edited by experts in the field with chapter contributions from subject area specialists Brings together the two main approaches in immersion optical clearing into one cohesive book
Author: Albert Cerussi
Publisher:
ISBN:
Category :
Languages : en
Pages : 131
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Book Description
Near-infrared (NIR) optical spectroscopy demonstrates unique possibilities for non-invasively monitoring tissue physiology. A bedside-capable instrument, using low levels of non-ionizing NIR light delivered by a hand-held probe, measures both absorption and scattering properties of tissues. A diffusive model for photons traveling through large tissue volumes quantifies oxygenated and deoxygenated hemoglobin, water, and lipid by their absorption signatures. Cellular density, fat, and collagen content are evaluated from the measured light- scattering spectra. This quantitative functional information cannot be obtained with other non-invasive radiological techniques. The prototype instrument revealed physiological changes in breast consistent with age-dependent histological alterations in 28 healthy female volunteers. A preliminary in vivo measurement of the therapeutic efficacy of two chemotherapy agents on a tumor in a human subject is also presented.
Author: Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging
Publisher: National Academies Press
ISBN: 0309552923
Category : Science
Languages : en
Pages : 261
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Book Description
This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.
Author: David F. Wilson
Publisher: Springer Science & Business Media
ISBN: 1461502055
Category : Science
Languages : en
Pages : 395
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Book Description
The ISOTT 2001 local organizing committee was pleased to welcome over 140 delegates from around the world to the 29th annual general meeting of the International Society for Oxygen Transport to Tissue. The meeting was held in historic Philadelphia, USA, on the campus of the University of Pennsylvania from August 11 to 15, 2001. In the tradition of ISOTT, the conference was a total immersion experience. Attendees were encouraged to eat together and spend their evenings relaxing together in a style that maximized exchange of ideas and interactions of younger scientists with their more senior colleagues. Delegates participated in a total of 122 presentations including poster displays, selected oral presentations, seminars by invited speakers and a round table discussion. In choosing invited speakers and oral presenters, special emphasis was placed on methods for oxygen measurement in living tissue and application of these technologies to understanding physiological and biochemical basis for pathology related to tissue oxygenation. All of the manuscripts contained in this volume underwent both an editorial and scientific review, and only those meeting both criteria have been published. However, while all efforts have been made to eliminate editorial errors, some have undoubtedly been overlooked, for which the editors apologize.
Author: Henry H. Mantsch
Publisher: SPIE-International Society for Optical Engineering
ISBN:
Category : Medical
Languages : en
Pages : 346
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Book Description
