Mathematical and Statistical Methods for Genetic Analysis PDF Download
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Author: Kenneth Lange
Publisher: Springer Science & Business Media
ISBN: 0387217509
Category : Medical
Languages : en
Pages : 376
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Book Description
Written to equip students in the mathematical siences to understand and model the epidemiological and experimental data encountered in genetics research. This second edition expands the original edition by over 100 pages and includes new material. Sprinkled throughout the chapters are many new problems.
Author: Kenneth Lange
Publisher: Springer Science & Business Media
ISBN: 0387217509
Category : Medical
Languages : en
Pages : 376
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Book Description
Written to equip students in the mathematical siences to understand and model the epidemiological and experimental data encountered in genetics research. This second edition expands the original edition by over 100 pages and includes new material. Sprinkled throughout the chapters are many new problems.
Author: Lange
Publisher:
ISBN: 9788181281135
Category :
Languages : en
Pages : 386
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Book Description
Author: Nan M. Laird
Publisher: Springer Science & Business Media
ISBN: 1441973389
Category : Medical
Languages : en
Pages : 226
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Book Description
This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
Author: M.C. Yang
Publisher: CRC Press
ISBN: 9789056991340
Category : Mathematics
Languages : en
Pages : 264
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Book Description
Although the basic statistical theory behind modern genetics is not very difficult, most statistical genetics papers are not easy to read for beginners in the field, and formulae quickly become very tedious to fit a particular area of application. Introduction to Statistical Methods in Modern Genetics distinguishes between the necessary and unnecessary complexity in a presentation designed for graduate-level statistics students. The author keeps derivations simple, but does so without losing the mathematical details. He also provides the required background in modern genetics for those looking forward to entering this arena. Along with some of the statistical tools important in genetics applications, students will learn: How a gene is found How scientists have separated the genetic and environmental aspects of a person's intelligence How genetics are used in agriculture to improve crops and domestic animals What a DNA fingerprint is and why there are controversies about it Although the author assumes students have a foundation in basic statistics, an appendix provides the necessary background beyond the elementary, including multinomial distributions, inference on frequency tables, and discriminant analysis. With clear explanations, a multitude of figures, and exercise sets in each chapter, this text forms an outstanding entrée into the rapidly expanding world of genetic data analysis.
Author: Andreas Ziegler
Publisher: John Wiley & Sons
ISBN: 3527324534
Category : Science
Languages : en
Pages : 522
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Book Description
This is the second edition of the successful textbook written by the prize-winning scientist Andreas Ziegler, former President of the German Chapter of the International Biometric Society, and Inke Konig, who has been teaching the subject over many years. The book gives a comprehensive introduction into the relevant statistical methods in genetic epidemiology. The second edition is thoroughly revised, partly rewritten and includes new chapters on segregation analysis, twin studies and estimation of heritability. The book is ideally suited for advanced students in epidemiology, genetics, statistics, bioinformatics and biomathematics. Like in the first edition the book contains many problems and solutions.
Author: Yogendra P. Chaubey
Publisher: World Scientific
ISBN: 981441798X
Category : Business & Economics
Languages : en
Pages : 276
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Book Description
This volume consists of a series of research papers presented at the conference Statistics 2011 Canada: 5th Canadian Conference in Applied Statistics held together with the 20th conference of the Forum for Interdisciplinary Mathematics titled, OC Interdisciplinary Mathematical & Statistical TechniquesOCO. These papers cover a wide range of topics from applications of Mathematics and Statistics such as Selection Bias in Surveys, Biomarker Discovery, Analysis of Earth Temperature, Supply Chain Management, Trimmed ANOVA, Zero-inflated Data, Non-Gaussian Time Series, and Stochastic Ordering; Classification, Nonparametric Test, and Jackknifed Ridge Estimator; Bayes Factor; Random Graphs and Error Correcting Codes; Meta Analysis; and National Health Plans and Risk Reduction through Supply Chain.The topics have been reviewed by experts in the field and the selected papers are expected to provide a topical resource on the subjects concerned.
Author: Susan R. Wilson
Publisher: EOLSS Publications
ISBN: 1905839375
Category : Science
Languages : en
Pages : 466
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Book Description
Biometrics is a component of Encyclopedia of Mathematical Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. Biometry is a broad discipline covering all applications of statistics and mathematics to biology. The Theme Biometrics is divided into areas of expertise essential for a proper application of statistical and mathematical methods to contemporary biological problems. These volumes cover four main topics: Data Collection and Analysis, Statistical Methodology, Computation, Biostatistical Methods and Research Design and Selected Topics. These volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
Author: David Siegmund
Publisher: Springer Science & Business Media
ISBN: 0387496866
Category : Medical
Languages : en
Pages : 337
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Book Description
This book details the statistical concepts used in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. It presents elementary principles of probability and statistics, which are implemented by computational tools based on the R programming language to simulate genetic experiments and evaluate statistical analyses. Each chapter contains exercises, both theoretical and computational, some routine and others that are more challenging. The R programming language is developed in the text.
Author: Jie Chen
Publisher: Springer Science & Business Media
ISBN: 0817648011
Category : Mathematics
Languages : en
Pages : 282
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Book Description
This revised and expanded second edition is an in-depth study of the change point problem from a general point of view, as well as a further examination of change point analysis of the most commonly used statistical models. Change point problems are encountered in such disciplines as economics, finance, medicine, psychology, signal processing, and geology, to mention only several. More recently, change point analysis has been found in extensive applications related to analyzing biomedical imaging data and gene expression data. Extensive examples throughout the text emphasize key concepts and different methodologies used. New examples of change point analysis in modern molecular biology and other fields such as finance and air traffic control have been added to this second edition.
Author: Karim F. Hirji
Publisher: CRC Press
ISBN: 142003619X
Category : Mathematics
Languages : en
Pages : 1066
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Book Description
Researchers in fields ranging from biology and medicine to the social sciences, law, and economics regularly encounter variables that are discrete or categorical in nature. While there is no dearth of books on the analysis and interpretation of such data, these generally focus on large sample methods. When sample sizes are not large or the data are
