Mammary Stromal Effects on Epithelial Differentiation and Expression of ESX and ErbB2 (HER2/neu). PDF Download
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Languages : en
Pages : 0
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A novel system for studying growth of normal human mammary epithelium in vivo as grafts in athymic nude mice has been developed. The key feature of this model is the reconstitution of the epithelial-stromal interactions required for normal growth and differentiation of the human mammary epithelium, which produces ducts that are comparable to the normal human mammary gland. Human breast epithelial organoids were combined with mammary fibroblasts from mouse or human origin in collagen gels, which were subsequently transplanted under the renal capsule of female nude mice hosts. The resulting grafts showed an increase in the ductal density than observed previously. These ducts expressed appropriate markers for luminal and myoepithelial cells and steroid receptors. This model allows for a variety of epithelial and stromal cells to be used in combination, which would aid in understanding key factors that regulate normal human mammary gland development. The manuscript detailing this data has been accepted for publication in the December 2002 issue of Endocrinology. The experiments currently in progress utilize both normal and tumor epithelium and carcinoma associated fibroblasts (CAF) in this model to assess the effect of CAF on the development of normal human mammary epithelium. CAF from a variety of tumors including ErbB2 positive tumors will be used.
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Languages : en
Pages : 0
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Book Description
A novel system for studying growth of normal human mammary epithelium in vivo as grafts in athymic nude mice has been developed. The key feature of this model is the reconstitution of the epithelial-stromal interactions required for normal growth and differentiation of the human mammary epithelium, which produces ducts that are comparable to the normal human mammary gland. Human breast epithelial organoids were combined with mammary fibroblasts from mouse or human origin in collagen gels, which were subsequently transplanted under the renal capsule of female nude mice hosts. The resulting grafts showed an increase in the ductal density than observed previously. These ducts expressed appropriate markers for luminal and myoepithelial cells and steroid receptors. This model allows for a variety of epithelial and stromal cells to be used in combination, which would aid in understanding key factors that regulate normal human mammary gland development. The manuscript detailing this data has been accepted for publication in the December 2002 issue of Endocrinology. The experiments currently in progress utilize both normal and tumor epithelium and carcinoma associated fibroblasts (CAF) in this model to assess the effect of CAF on the development of normal human mammary epithelium. CAF from a variety of tumors including ErbB2 positive tumors will be used.
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Languages : en
Pages : 7
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Book Description
A novel system for studying growth of normal human mammary epithelium in vivo as grafts in athymic nude mice has been developed. The key feature of this mode is the reconstitution of the epithelial-stromal interactions that occur in the normal human breast. This model has been used to demonstrate the ability of carcinoma associated fibroblasts to cause abnormal growth of normal human mammary epithelium. The renal grafting technique has also been used to study tumor growth and tumor inhibition.
Author: Yiyang Dong
Publisher: Springer Nature
ISBN: 9813348380
Category : Science
Languages : en
Pages : 470
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Book Description
This book outlines comprehensively the main medical uses of aptamers, from diagnosis to therapeutics in fourteen chapters. Pioneering topics covered include aptamer pharmaceuticals, aptamers for malign tumors, aptamers for personalized therapeutics and aptamers for point-of-care testing. The book offers an essential guide for medical scientists interested in developing aptamer-based schemes for better theranostics. It is therefore of interest for not only academic researchers, but also practitioners and medical researchers in various fields of medical science, medical research and bio-analytical chemistry.
Author: Alfred E. Chang
Publisher: Springer Science & Business Media
ISBN: 0387310568
Category : Medical
Languages : en
Pages : 2040
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Book Description
Title consistently uses the evidence-based approach Evidence-based tables make documentation of care plan easy Interdisciplinary orientation – all aspects of patient care are covered Only book that involves experts from the entire range of cancer treatment in the fields of medical, surgical and radiation oncology Includes hot topics such as prevention and breast cancer Offers ground-breaking sections on the latest research and clinical applications in cancer survivorship Chapter on PET addresses imaging issues and how to get the best results Most comprehensive sections on the biology and epidemiology of cancer as compared to competitors
Author: Arnold Jay Levine
Publisher: Cold Spring Harbor Laboratory Press
ISBN: 9780879691684
Category : Medical
Languages : en
Pages : 302
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Category : Oncology
Languages : en
Pages : 546
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Book Description
Author: Shuguang Ma
Publisher: Elsevier Science
ISBN: 0128200189
Category : Science
Languages : en
Pages : 708
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Book Description
Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade's numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia
Author: Carol K. Redmond
Publisher: John Wiley & Sons
ISBN: 9780471822110
Category : Medical
Languages : en
Pages : 530
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Book Description
The second volume in the Wiley reference series in Biostatistics. Featuring articles from the prestigious Encyclopedia of Biostatistics, many of which have been fully revised and updated to include recent developments, Biostatistics in Clinical Trials also includes up to 25% newly commissioned material reflecting the latest thinking in: Bayesian methods Benefit/risk assessment Cost-effectiveness Ethics Fraud With exceptional contributions from leading experts in academia, government and industry, Biostatistics in Clinical Trials has been designed to complement existing texts by providing extensive, up-to-date coverage and introducing the reader to the research literature. Offering comprehensive coverage of all aspects of clinical trials Biostatistics in Clinical Trials: Includes concise definitions and introductions to numerous concepts found in current literature Discusses the software and textbooks available Uses extensive cross-references helping to facilitate further research and enabling the reader to locate definitions and related concepts Biostatistics in Clinical Trials offers both academics and practitioners from various disciplines and settings, such as universities, the pharmaceutical industry and clinical research organisations, up-to-date information as well as references to assist professionals involved in the design and conduct of clinical trials.
Author: Yiyang Dong
Publisher: John Wiley & Sons
ISBN: 3527342672
Category : Science
Languages : en
Pages : 426
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Book Description
An essential guide that puts the focus on method developments and applications in aptamers In recent years, aptamer-based systems have been developed for a wide-range of analytical and medical applications. Aptamers for Analytical Applications offers an introduction to the topic, outlines the common protocols for aptamer synthesis, as well as providing information on the different optimization strategies that can obtain higher affinities to target molecules. The contributors?noted experts on the topic?provide an in-depth review of the characterization of aptamer-target molecule interaction and immobilization strategies and discuss the developments of methods for all the relevant applications. The book outlines different schemes to efficiently immobilize aptamers on substrates as well as summarizing the characterization methods for aptamer-ligand complexes. In addition, aptamer-based colorimetric, enzyme-linked, fluorescent, electrochemical, lateral flow and non-labeling analytical methods are presented. The book also reflects state-of-the-art and emerging applications of aptamer-based methods. This important resource: -Provides a guide to aptamers which provide highly specific and sensitive molecular recognition, with affinities in the range of antibodies and are much cheaper to produce -Offers a discussion of the analytical method developments and improvements with established systems and beyond -Offers a comprehensive guide to all the relevant application areas -Presents an authoritative book from contributors who are noted experts in the field Written for analytical chemists, biochemists, analytical researchers, Aptamers for Analytical Applications is a comprehensive book that adopts a methodological point of view to the important aspects of aptamer generation and modification with a strong emphasis on method developments for relevant applications.
Author: American Society of Agronomy
Publisher: Wiley-Blackwell
ISBN: 9780891182832
Category : Agriculture
Languages : en
Pages : 59
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Book Description
The AGRONOMY AND HEALTH theme encompasses many soil-plant-animal relationships that influence "total health" - reproduction, longevity, vigor, mental capacity, and happiness of people everywhere. The high availabilities of nutritious foods is an absolute necessity. We sometimes forget that plant life developed before animal life. Plants alone utilize radiant energy to fix simple carbohydrates that with other materials are subsequently metabolized into organic compounds to supply energy and nutritional needs for all animal life. Animal products improve the nutritional value, palatability, and pleasure of eating.
