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Author: U. Metzger
Publisher: Springer Science & Business Media
ISBN: 3642824323
Category : Medical
Languages : en
Pages : 170
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Book Description
One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.
Author: U. Metzger
Publisher: Springer Science & Business Media
ISBN: 3642824323
Category : Medical
Languages : en
Pages : 170
Get Book Here
Book Description
One reason for failure to cure solid tumors by surgery appears to be the impossibility of controlling metastases that are present but latent at the time of operation. This failure is a common clinical experience with aggressive neoplasms. but it is not always appreciated in tumors with longer survival times. e. g .• breast and colon cancer. In addition. recent evidence indicates that after resection of a primary tumor micrometas tases from it might be enhanced by suppression of immune and reticu loendothelial functions of the host. Other factors, such as increase of coagulability and stress in the perioperative period, can also promote tumor growth. The development of new metastases might be facilitated by cells forced into the circulation during operative manipulations. Such events could be important for the outcome of treatment and it is suggested that preventive measures should be directed to this systemic component of solid tumors. Radical surgery can reduce the number of tumor cells to a subclinical 3 6 stage (10 to 10 cells) in which chemotherapy might be more effective than in advanced stages. Chemotherapy, on the other hand, might aggravate the surgical morbidity by influencing the wound healing pro cess, by decreasing the immune response, and/or by toxicity to the bone marrow and to the gastrointestinal tract, for example.
Author: K. M. Shea
Publisher:
ISBN: 9781950635146
Category :
Languages : en
Pages :
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Book Description
Author: Holly Black
Publisher: Scholastic Inc.
ISBN: 0545522277
Category : Juvenile Fiction
Languages : en
Pages : 295
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Book Description
From NEW YORK TIMES bestselling authors Holly Black and Cassandra Clare comes a riveting new series that defies what you think you know about the world of magic. Most kids would do anything to pass the Iron Trial. Not Callum Hunt. He wants to fail. All his life, Call has been warned by his father to stay away from magic. If he succeeds at the Iron Trial and is admitted into the Magisterium, he is sure it can only mean bad things for him. So he tries his best to do his worst - and fails at failing. Now the Magisterium awaits him. It's a place that's both sensational and sinister, with dark ties to his past and a twisty path to his future. The Iron Trial is just the beginning, for the biggest test is still to come . . . From the remarkable imaginations of bestselling authors Holly Black and Cassandra Clare comes a heart-stopping, mind-blowing, pulse-pounding plunge into the magical unknown.
Author: Davies Owen
Publisher: Routledge
ISBN: 1317867556
Category : History
Languages : en
Pages : 244
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Book Description
In 1856 William Dove, a young tenant farmer, was tried and executed for the poisoning of his wife Harriet. The trial might have been a straightforward case of homicide, but because Dove became involved with Henry Harrison, a Leeds wizard, and demonstrated through his actions and words a strong belief in magic and the powers of the devil, considerable effort was made to establish whether these beliefs were symptomatic of insanity. It seems that Dove murdered his wife to hasten a prediction made by Harrison that he would remarry a more attractive and wealthy woman. Dove employed Harrison to perform various acts of magic, and also made his own written pact with the devil to improve his personal circumstances. The book will study Dove’s beliefs and Harrison’s activities within the rural and urban communities in which they lived, and examine how modern cultures attempted to explain this largely hidden mental world, which was so sensationally exposed. The Victorian period is often portrayed as an age of great social and educational progress. This book shows how beliefs dismissed by some Victorians as ‘medieval superstitions’ continued to influence the thoughts and actions of many people, viz most famously Conan `table tapper' Doyle.
Author: Per Sörlin
Publisher: BRILL
ISBN: 9789004111837
Category : History
Languages : en
Pages : 262
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Book Description
Based on an extensive body of Swedish sources, this study presents new information on the regional pattern of European witch-trials, providing insight into how social and cultural perceptions of local wichcraft were generated by interactions in the legal process.
Author: Michael J. Domanski
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781779456
Category : Medical
Languages : en
Pages : 228
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Book Description
This handbook is a ready reference on the theory and operation of modern large, multicenter randomized clinical trials, which have come to be the basis of evidence-based medicine. Written in a concise, engaging style geared to physicians, the book explains the rationale and theoretical foundations for clinical trials, the components of modern clinical trials including their functions and interactions, and practical considerations in the design and implementation of these studies including an introduction to the economics and business aspects.
Author: George R. R. Martin
Publisher: Bantam
ISBN: 0399593780
Category : Fiction
Languages : en
Pages : 577
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Book Description
A new anthology celebrating the witches and sorcerers of epic fantasy—featuring stories by George R. R. Martin, Scott Lynch, Megan Lindholm, and many others! Hot on the heels of Gardner Dozois’s acclaimed anthology The Book of Swords comes this companion volume devoted to magic. How could it be otherwise? For every Frodo, there is a Gandalf . . . and a Saruman. For every Dorothy, a Glinda . . . and a Wicked Witch of the West. What would Harry Potter be without Albus Dumbledore . . . and Severus Snape? Figures of wisdom and power, possessing arcane, often forbidden knowledge, wizards and sorcerers are shaped—or misshaped—by the potent magic they seek to wield. Yet though their abilities may be godlike, these men and women remain human—some might say all too human. Such is their curse. And their glory. In these pages, seventeen of today’s top fantasy writers—including award-winners Elizabeth Bear, John Crowley, Kate Elliott, K. J. Parker, Tim Powers, and Liz Williams—cast wondrous spells that thrillingly evoke the mysterious, awesome, and at times downright terrifying worlds where magic reigns supreme: worlds as far away as forever, and as near as next door. FEATURING SIXTEEN ALL-NEW STORIES: “The Return of the Pig” by K. J. Parker “Community Service” by Megan Lindholm “Flint and Mirror” by John Crowley “The Friends of Masquelayne the Incomparable” by Matthew Hughes “The Biography of a Bouncing Boy Terror: Chapter Two: Jumping Jack in Love” by Ysabeau S. Wilce “Song of Fire” by Rachel Pollack “Loft the Sorcerer” by Eleanor Arnason “The Governor” by Tim Powers “Sungrazer” by Liz Williams “The Staff in the Stone” by Garth Nix “No Work of Mine” by Elizabeth Bear “Widow Maker” by Lavie Tidhar “The Wolf and the Manticore” by Greg Van Eekhout “The Devil’s Whatever” by Andy Duncan “Bloom” by Kate Elliott “The Fall and Rise of the House of the Wizard Malkuril” by Scott Lynch Plus George R. R. Martin’s classic story “A Night at the Tarn House” and an introduction by Gardner Dozois Praise for The Book of Magic “In The Book of Magic, you get everything you expect and more! Assembling seventeen great authors in one place is a difficult job but this book, with a lot of help from editor Gardner Dozois, does just that. . . . This compilation is a treat for any who love a good fantasy tale.”—Geeks of Doom
Author: Peter Orullian
Publisher: Macmillan
ISBN: 0765325721
Category : Fiction
Languages : en
Pages : 672
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Book Description
The gods who created this world have abandoned it. In their mercy, however, they chained the rogue god—and the monstrous creatures he created to plague mortalkind—in the vast and inhospitable wasteland of the Bourne. The magical Veil that contains them has protected humankind for millennia and the monsters are little more than tales told to frighten children. But the Veil has become weak and creatures of Nightmare have come through. To fight them, the races of men must form a great alliance to try and stop the creatures. But there is dissent. One king won't answer the call, his pride blinding him even to the poison in his own court. Another would see Convocation fail for his own political advantage. And still others believe Convocation is not enough. Some turn to the talents of the Sheason, who can shape the very essence of the world to their will. But their order is divided, on the brink of collapse. Tahn Junell remembers friends who despaired in a place left barren by war. One of the few who have actually faced the unspeakable horde in battle, Tahn sees something else at work and wonders about the nature of the creatures on the other side of the Veil. He chooses to go to a place of his youth, a place of science, daring to think he can find a way to prevent slaughter, prevent war. And his choices may reshape a world . . . . The second title in the Vault of Heaven series, Peter Orullian's Trial of Intentions is a mesmerizing fantasy epic that turns the conventions of the genre on its head
Author: Joseph Ragaz
Publisher: Springer Science & Business Media
ISBN: 3642826717
Category : Medical
Languages : en
Pages : 172
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Book Description
Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.
Author: Peush Sahni
Publisher: Springer
ISBN: 9811332274
Category : Medical
Languages : en
Pages : 272
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Book Description
The 25th volume of this highly successful series covers a range of interesting topics, including biological therapy in inflammatory bowel disease, recent surgical approaches in rectal cancer, tumor markers in HPB and GI malignancies, bridging therapy for hepatocellular carcinoma, adjuncts to liver resection, IgG-related HPB diseases, ERCP-induced perforations and superior mesenteric artery syndrome. As in the previous volumes, the chapter on advances in GI surgery reviews the important new developments in the field. The GI Surgery Annual 25th Volume provides up-to-date information on current hot topics.
