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Author: Jerold Chun
Publisher: John Wiley & Sons
ISBN: 1118531302
Category : Science
Languages : en
Pages : 836
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Book Description
The current state of the science supporting new research in lysophospholipids The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections: Receptors and other possible effectors Enzymes Physiology and pathophysiology Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.
Author: Jerold Chun
Publisher: John Wiley & Sons
ISBN: 1118531302
Category : Science
Languages : en
Pages : 836
Get Book Here
Book Description
The current state of the science supporting new research in lysophospholipids The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections: Receptors and other possible effectors Enzymes Physiology and pathophysiology Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.
Author:
Publisher: ScholarlyEditions
ISBN: 1481644637
Category : Medical
Languages : en
Pages : 17
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Book Description
Lysophospholipid Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Lysophospholipid Receptors in a compact format. The editors have built Lysophospholipid Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Lysophospholipid Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Lysophospholipid Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: Christine McGiffert
Publisher:
ISBN:
Category :
Languages : en
Pages : 314
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Book Description
Author: Linnea M. Baudhuin
Publisher:
ISBN:
Category : Cell receptors
Languages : en
Pages : 356
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Book Description
Author: Stefan Offermanns
Publisher: Springer Science & Business Media
ISBN: 3540389164
Category : Medical
Languages : en
Pages : 1515
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Book Description
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Author: Edward J. Goetzl
Publisher:
ISBN: 9781573312134
Category : Cell receptors
Languages : en
Pages : 0
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Book Description
The cellular-wide activities of the lipid mediators have made them intrinsic to research on such prevalent cell-based pathologies as obesity, cell immunity, and neural degeneration. The influence of the lyphospholipids and eicosanoid families, especially LPA and S1P, needs to be defined for the progress of research on these important cancer and cardiovascular diseases. These papers and posters focus on lipid biochemistry and eicosanoid generation, and highlight findings on their roles in nuclear signaling, in cellular proliferation, differentiation, and in cell apoptosis and transformation. Participants reviews of the psychological effects of the lipids in the nervous, immune and cardiovascular systems lead directly to a statement of pharmaceutical approaches with small molecule agonists and antagonists that could offer direct results for these critical public health problems.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 80
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Book Description
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are widely-distributed stimuli of cellular growth and functions, which are generated enzymatically from precursors in membranes of activated normal cells and at much higher levels from many types of cancers. A subfamily of 0 protein-coupled receptors encoded by endothelial differentiation genes (Edg Rs) bind and transduce cellular signals from LPA (Edg-2, -4, -7) and S1P (Edg-l, -3,-S, -6, and -8). Human breast cancer cells (BCCs) express principally Edg-3, less Edg-4, very low levels of Edg-2 and Edg-5, and no Edg-1, -6,-? or -8. BCCs have much higher levels of Edg-3 S1P Rs than normal human breast epithelial cells. These Edg Rs mediate proliferation of BCCs directly by signaling growth-related immediate-early genes, through a distinctive set of transcription factors, and indirectly by increasing BCCs secretion of several autocrine protein growth factors. Delivery of LPA to BCCs by specific plasma protein carriers, such as gelsolin, and novel mechanisms for regulation of expression of Edg-3 Rs also may distinguish mechanisms of action of SIP and LPA in BCCs from those in normal breast epithelial cells. Detection of elevated levels of Edg-3 Rs and splice variants of Edg-3 Rs may become a diagnostic index of breast cancer and Edg R- directed antagonists may suppress growth and dissemination of breast cancers.
Author: Marcel E. Durieux
Publisher: Springer
ISBN: 9783540590989
Category : Cellular signal transduction
Languages : en
Pages : 0
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Book Description
Addresses the varied cellular effects of lysophosphatidate (LPA) and the molecular biology of its signaling pathway to the extent that it has been dissected thus far. Covers the structural properties and metabolic role of LPA; smooth muscle; mitogenic effects and Ca2 release; antimitogenesis; blood; morphology; cytoskeleton; non-mammals; receptors and membrane G proteins; cAMP; intracellular signaling; and sphingosine-1- phosphate. Annotation copyright by Book News, Inc., Portland, OR
Author: James John Achilles Contos
Publisher:
ISBN:
Category :
Languages : en
Pages : 534
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Book Description
Author: Ralph A. Bradshaw
Publisher: Academic Press
ISBN: 0080920918
Category : Science
Languages : en
Pages : 3188
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Book Description
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
