Development of Selective DNA-Interacting Ligands PDF Download
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Author: Sefan Asamitsu
Publisher: Springer Nature
ISBN: 9811577161
Category : Science
Languages : en
Pages : 111
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Book Description
This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases. Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity. This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.
Author: Sefan Asamitsu
Publisher: Springer Nature
ISBN: 9811577161
Category : Science
Languages : en
Pages : 111
Get Book Here
Book Description
This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases. Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity. This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.
Author: Weibo Cai
Publisher: CRC Press
ISBN: 1315353784
Category : Medical
Languages : en
Pages : 649
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Book Description
Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.
Author: Marie Helene Delville
Publisher: John Wiley & Sons
ISBN: 3527807101
Category : Technology & Engineering
Languages : en
Pages : 1009
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Book Description
Hybrid organic-inorganic materials and the rational design of their interfaces open up the access to a wide spectrum of functionalities not achievable with traditional concepts of materials science. This innovative class of materials has a major impact in many application domains such as optics, electronics, mechanics, energy storage and conversion, protective coatings, catalysis, sensing and nanomedicine. The properties of these materials do not only depend on the chemical structure, and the mutual interaction between their nano-scale building blocks, but are also strongly influenced by the interfaces they share. This handbook focuses on the most recent investigations concerning the design, control, and dynamics of hybrid organic-inorganic interfaces, covering: (i) characterization methods of interfaces, (ii) innovative computational approaches and simulation of interaction processes, (iii) in-situ studies of dynamic aspects controlling the formation of these interfaces, and (iv) the role of the interface for process optimization, devices, and applications in such areas as optics, electronics, energy and medicine.
Author: Guido Kickelbick
Publisher: John Wiley & Sons
ISBN: 3527610480
Category : Science
Languages : en
Pages : 516
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Book Description
Hybrid materials have currently a great impact on numerous future developments including nanotechnology. This book presents an overview about the different types of materials, clearly structured into synthesis, characterization and applications. A perfect starting point for everyone interested in the field, but also for the specialist as a source of high quality information.
Author: Stefan Odenbach
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110568837
Category : Science
Languages : en
Pages : 1172
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Book Description
Externally tunable properties allow for new applications of magnetic hybrid materials containing magnetic micro- and nanoparticles in sensors and actuators in technical and medical applications. By means of easy to generate and control magnetic fields, changes of the internal particle arrangements and the macroscopic properties can be achieved. This monograph delivers the latest insights into multi-scale modelling, experimental characterization, manufacturing and application of those magnetic hybrid materials.
Author: Komal Rizwan
Publisher: Springer Nature
ISBN: 9811945381
Category : Technology & Engineering
Languages : en
Pages : 508
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Book Description
This book elaborates on the fabrication of organic-inorganic hybrid nanomaterials, their advantages, self-assembly and their applications in diverse fields of energy, biotechnology, biomedical and environment. The contents provide insight into tools, tricks and challenges associated with techniques of fabrication and future challenges and risks. This book also discusses the properties of modern hybrid nanomaterials and their performance, durability, reproducibility and sensitivity. It will be useful for students and researchers in the area of nanotechnology, science, engineering and environmental chemistry. This volume will also be useful for researchers and professionals working on nanohybrid materials.
Author: Xiao-Feng Wu
Publisher: John Wiley & Sons
ISBN: 3527348956
Category : Science
Languages : en
Pages : 1780
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Book Description
The Chemical Transformations of C1 Compounds A comprehensive exploration of one-carbon molecule transformations The chemistry of one-carbon molecules has recently gained significant prominence as the world transitions away from a petroleum-based economy to a more sustainable one. In The Chemical Transformations of C1 Compounds, an accomplished team of chemists delivers an in-depth overview of recent developments in the field of single-carbon chemistry. The three-volume book covers all major C1 sources, including carbon monoxide, carbon dioxide, methane, methanol, formic acid, formaldehyde, carbenes, C1 halides, and organometallics. The editors have included resources discussing the main reactions and transformations into feedstock chemicals of each of the major C1 compounds reviewed in dedicated chapters. Readers will discover cutting-edge material on organic transformations with MeNO2, DMF, DCM, methyl organometallic reagents, CCl4, CHCl3, and CHBr3, as well as recent achievements in cyanation reactions via cross-coupling. The book also offers: Thorough introductions to chemical transformations of CH4, methods of CH4 activation, chemical transformations of CH3OH and synthesis alkenes from CH3OH Comprehensive explorations of the carbonylation of MeOH, CH2O in organic synthesis, organic transformations of HCO2H, and hydrogen generation from HCO2H Practical discussions of the carbonylation of unsaturated bonds with heterogeneous and homogeneous catalysts, as well as the carbonylation of C(sp2)-X bonds and C(sp3)-X bonds In-depth examinations of carbonylative C-H bond activation and radical carbonylation Perfect for organic and catalytic chemists, The Chemical Transformations of C1 Compounds is also an ideal resource for industrial chemists, chemical engineers, and practitioners at energy supply companies.
Author: Ahmad Fauzi Ismail
Publisher: Royal Society of Chemistry
ISBN: 183916221X
Category : Science
Languages : en
Pages : 323
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Book Description
Functional and structural nanomaterials are emerging materials that display interesting physical and chemical properties because of their size and surface area to volume ratio. Applications for these materials include uses in removing pollutants from the environment. Looking at the current state-of-the-art as well as future trends in the use of nanomaterials for tackling environmental issues this book covers everything from the synthesis and characterisation of these materials to their use in the removal of specific contaminants. Functional Hybrid Nanomaterials for Environmental Remediation is a useful resource both for nanomaterial scientists interested in the real world application of hybrid nanomaterials and for environmental chemists and environmental engineers interested in novel materials for environmental remediation.
Author: John Bremner
Publisher: Springer Nature
ISBN: 9811609993
Category : Technology & Engineering
Languages : en
Pages : 193
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Book Description
This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal chemistry design and laboratory development of multiply active antibacterials. The scope of the book appeals to readers who are researching in the field of antibacterials using the approach of medicinal chemistry design and drug development.
Author: Bo Wang
Publisher: Royal Society of Chemistry
ISBN: 1839161531
Category : Science
Languages : en
Pages : 407
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Book Description
This book documents the latest research progress in MOF/COF-polymer hybrid materials and reviews and summarises hybridization strategies to achieve MOF/COF polymeric composites.
