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Author: Matthew M. Hayward
Publisher: Springer Science & Business Media
ISBN: 364201075X
Category : Science
Languages : en
Pages : 224
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Book Description
High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi?ed from one or more of these screening methods, they need to be thoroughly characterized in order to con?rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi?ed, preliminary optimization through synthetic modi?cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef?cient approach to the identi?cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi?- tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci?c points. There are also a number of excellent reviews covering the lead identi?cation process [1–6].
Author: Matthew M. Hayward
Publisher: Springer Science & Business Media
ISBN: 364201075X
Category : Science
Languages : en
Pages : 224
Get Book Here
Book Description
High quality leads provide the foundation for the discovery of successful clinical development candidates, and therefore the identi?cation of leads is an essential part of drug discovery. The process for the identi?cation of leads generally starts with the screening of a compound collection, either an HTS of a relatively large compound collection (hundreds of thousands to one million plus compounds) or a more focused screen of a smaller set of compounds that have been preselected for the target of interest. Virtual screening methods such as structure-based or pharmacophore-based searches can complement or replace one of the above approaches. Once hits are identi?ed from one or more of these screening methods, they need to be thoroughly characterized in order to con?rm activity and identify areas in need of optimization. Finally, once fully characterized hits are identi?ed, preliminary optimization through synthetic modi?cation is carried out to generate leads. Parallel optimization of all properties, including biological, physicochemical, and ADME is the most ef?cient approach to the identi?cation of leads. Hit characterization is described in the previous chapter. The focus of this chapter is on hit optimization and the identi?- tion of leads. After a general overview of these processes, examples taken from the literature since 2001 will be used to illustrate speci?c points. There are also a number of excellent reviews covering the lead identi?cation process [1–6].
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309439124
Category : Social Science
Languages : en
Pages : 171
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Book Description
Estimates indicate that as many as 1 in 4 Americans will experience a mental health problem or will misuse alcohol or drugs in their lifetimes. These disorders are among the most highly stigmatized health conditions in the United States, and they remain barriers to full participation in society in areas as basic as education, housing, and employment. Improving the lives of people with mental health and substance abuse disorders has been a priority in the United States for more than 50 years. The Community Mental Health Act of 1963 is considered a major turning point in America's efforts to improve behavioral healthcare. It ushered in an era of optimism and hope and laid the groundwork for the consumer movement and new models of recovery. The consumer movement gave voice to people with mental and substance use disorders and brought their perspectives and experience into national discussions about mental health. However over the same 50-year period, positive change in American public attitudes and beliefs about mental and substance use disorders has lagged behind these advances. Stigma is a complex social phenomenon based on a relationship between an attribute and a stereotype that assigns undesirable labels, qualities, and behaviors to a person with that attribute. Labeled individuals are then socially devalued, which leads to inequality and discrimination. This report contributes to national efforts to understand and change attitudes, beliefs and behaviors that can lead to stigma and discrimination. Changing stigma in a lasting way will require coordinated efforts, which are based on the best possible evidence, supported at the national level with multiyear funding, and planned and implemented by an effective coalition of representative stakeholders. Ending Discrimination Against People with Mental and Substance Use Disorders: The Evidence for Stigma Change explores stigma and discrimination faced by individuals with mental or substance use disorders and recommends effective strategies for reducing stigma and encouraging people to seek treatment and other supportive services. It offers a set of conclusions and recommendations about successful stigma change strategies and the research needed to inform and evaluate these efforts in the United States.
Author: Teresa L. Thompson
Publisher: SAGE Publications
ISBN: 1483346412
Category : Reference
Languages : en
Pages : 1663
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Book Description
From the dynamics of interpersonal communication between health professionals and clients to global command-and-control during public health emergencies that cross international borders, the field of health communication bridges many disciplines and involves efforts from the micro to the macro. It involves navigating personal, cultural, and political complexities and an ability to distill complex technical science into quickly and easily understood terms for ready distribution by the mass media--or to an individual patient or to the parent of an ailing child. Despite an abundance of textbooks, specialized monographs, and academic handbooks, this is the first encyclopedic reference work in this area, covering the breadth of theory and research on health communication, as well as their practical application. Features: Nearly 600 original articles are organized A-to-Z within a three-volume set to provide comprehensive coverage of this exciting field, including such topics as theories and research traditions; evaluation and assessment; cultural complexities; high risk and special populations; message design and campaigns; provider/patient interaction issues; media issues; and more. All articles were specifically commissioned for this work, signed and authored by key figures in the field, and conclude with cross reference links and suggestions for further reading. Appendices include a Resource Guide with annotated lists of classic books and articles, journals, associations, and web sites; a Glossary of specialized terms; and a Chronology offering an overview and history of the field. A thematic Reader’s Guide groups related articles by broad topic areas as one handy search feature on the e-Reference platform, which also includes a comprehensive index of search terms. This A-to-Z three-volume reference is available in both print and online formats and is a must-have for libraries and researchers who seek comprehensive coverage of the theory, research, and applications of health communication.
Author: David M. Wasieleski
Publisher: Emerald Group Publishing
ISBN: 1800437927
Category : Business & Economics
Languages : en
Pages : 203
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Book Description
Volume Five of Business and Society 360 focuses on research from leading scholars in this discipline contribute to a 360-degree evaluation of theory, including cross-discipline research, empirical explorations, cross-cultural studies, literature critiques, and meta-analysis projects.
Author: Deborah E. Reidy
Publisher: iUniverse
ISBN: 1462047629
Category : Business & Economics
Languages : en
Pages : 202
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Book Description
Leadership can be exercised by anyone who cares enough. You don’t need to have a title, be charismatic, or even have confidence. You just need to be motivated to make a difference in the lives of people or causes you care about. In Why Not Lead? author Deborah E. Reidy provides a practical and accessible guide for families of people with disabilities and their allies who are motivated to bring about positive change and who are looking for guidance on their journey. Drawn from decades of experience, Why Not Lead? uses a combination of case studies, short narratives, and personal exercises to provide an understanding of what leadership is, to assist in strengthening your motivation, and to deepen your understanding and application of core leadership practices. “Wonderful, heartful, useful … Reidy’s insights and stories illuminate the meaning of life and the practices of leadership …” —Ron Heifetz, author, teacher, and founder of the Center for Public Leadership at Harvard University
Author: Scott O. Lilienfeld
Publisher: John Wiley & Sons
ISBN: 1118661087
Category : Psychology
Languages : en
Pages : 409
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Book Description
Psychological Science Under Scrutiny explores a range of contemporary challenges to the assumptions and methodologies of psychology, in order to encourage debate and ground the discipline in solid science. Discusses the pointed challenges posed by critics to the field of psychological research, which have given pause to psychological researchers across a broad spectrum of sub-fields Argues that those conducting psychological research need to fundamentally change the way they think about data and results, in order to ensure that psychology has a firm basis in empirical science Places the recent challenges discussed into a broad historical and conceptual perspective, and considers their implications for the future of psychological methodology and research Challenges discussed include confirmation bias, the effects of grant pressure, false-positive findings, overestimating the efficacy of medications, and high correlations in functional brain imaging Chapters are authored by internationally recognized experts in their fields, and are written with a minimum of specialized terminology to ensure accessibility to students and lay readers
Author: Jae-Jae Spoon
Publisher: University of Michigan Press
ISBN: 0472117904
Category : History
Languages : en
Pages : 220
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Book Description
Strategic choices allow small parties to balance their interests and achieve success
Author: Shiloh Martin PhD
Publisher: Covenant Books, Inc.
ISBN:
Category : Psychology
Languages : en
Pages : 191
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Book Description
Finding Hope and Healing: A Christ-Centered Approach to Mental Illness is a book that offers a compassionate and insightful exploration of mental illness through a biblical lens. Written by Dr. Shiloh W. Martin, the book draws on his personal faith and professional expertise to provide guidance and encouragement for individuals struggling with mental health issues and their loved ones. The book explores various mental illnesses--such as depression, anxiety, and bipolar disorder--and uses scriptures to provide comfort, hope, and practical advice. The author emphasizes the importance of seeking professional help while also recognizing the power of faith in the healing process. With its compassionate tone and insightful guidance, Finding Hope and Healing is a valuable resource for anyone seeking to understand mental illness from a Christian perspective and find hope and healing in the midst of the struggles. He wrote this book to offer a different perspective on mental illness, one that combines the best of his professional expertise and faith. He believes that with the right approach and support, those struggling with mental illness can find hope and healing, and he hopes that his book can be a valuable resource for those seeking to understand and address mental illness from a Christian perspective.
Author: Mick Hurbis-Cherrier
Publisher: CRC Press
ISBN: 1136067906
Category : Performing Arts
Languages : en
Pages : 560
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Book Description
Voice & Vision is a comprehensive manual for the independent filmmakers and film students who want a solid grounding in the tools, techniques, and processes of narrative film in order to achieve their artistic vision. This book includes essential and detailed information on relevant film and digital video tools, a thorough overview of the filmmaking stages, and the aesthetic considerations for telling a visual story. The ultimate goal of this book is to help you develop your creative voice while acquiring the solid practical skills and confidence to use it. Unlike many books that privilege raw technical information or the line-producing aspects of production, Voice & Vision places creativity, visual expression, and cinematic ideas front and center. After all, every practical decision a filmmaker makes, like choosing a location, an actor, a film stock, a focal length, a lighting set-up, an edit point, or a sound effect is also an expressive one and should serve the filmmaker's vision. Every decision, from the largest conceptual choices to the smallest practical solutions, has a profound impact on what appears on the screen and how it moves an audience. "In Practice sidebars throughout Voice & Vision connect conceptual, aesthetic and technical issues to their application in the real world. Some provide a brief analysis of a scene or technique from easily rentable films which illustrate how a specific technology or process is used to support a conceptual, narrative, or aesthetic choice. Others recount common production challenges encountered on real student and professional shoots which will inspire you to be innovative and resourceful when you are solving your own filmmaking challenges.
Author: Ravi Godrick Vincent
Publisher: BookRix
ISBN: 375544688X
Category : Body, Mind & Spirit
Languages : en
Pages : 1262
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Book Description
In "An Esoteric Approach to The Bhagwad Gita," each verse is explained in 1.the context of Advainta Vedanta,Yoga .Sankhya 2.Western wisdom teachings' perspective 3. in terms of consciousness,subconsciouness and superconsciousness 4. interpreted in terms of will-power,wisdom and activity as far as possible. Embark on a transformative journey through the profound teachings of the Bhagavad Gita with "An Esoteric Approach to The Bhagwad Gita." This extraordinary book delves into the depths of each verse, offering a multi-dimensional exploration that goes beyond mere translation. Unlock the hidden wisdom and mysteries of this sacred scripture as the author presents an esoteric understanding, grounded in Hindu philosophy. But it doesn't stop there—the book expands the reader's perspective by integrating Western wisdom teachings, bridging the gap between ancient Eastern traditions and contemporary thought. Delve into the realms of consciousness, subconsciousness, and superconsciousness as you discover practical insights for personal growth and self-realization. Explore the interplay of willpower, wisdom, and activity, and learn to harmonize these essential elements of your being. "An Esoteric Approach to The Bhagwat Gita" is a profound guide that unlocks the hidden depths of this sacred scripture, empowering you to embrace its timeless wisdom and apply it to your life
