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Author: Kirill Kulikov
Publisher: Springer
ISBN: 3319941143
Category : Science
Languages : en
Pages : 197
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Book Description
This book introduces readers to the principles of laser interaction with biological cells and tissues with varying degrees of organization. In addition to considering the problems of biomedical cell diagnostics, and modeling the scattering of laser irradiation of blood cells for biological structures (dermis, epidermis, vascular plexus), it presents an analytic theory based on solving the wave equation for the electromagnetic field. It discusses a range of mathematical modeling topics, including optical characterization of biological tissue with large-scale and small-scale inhomogeneities in the layers; heating blood vessels using laser irradiation on the outer surface of the skin; and thermo-chemical denaturation of biological structures based on the example of human skin. In this second edition, a new electrodynamic model of the interaction of laser radiation with blood cells is presented for the structure of cells and the in vitro prediction of optical properties. The approach developed makes it possible to determine changes in cell size as well as modifications in their internal structures, such as transformation and polymorphism nucleus scattering, which is of interest for cytological studies. The new model is subsequently used to calculate the size distribution function of irregular-shape particles with a variety of forms and structures, which allows a cytological analysis of the observed deviations from normal cells.
Author: Kirill Kulikov
Publisher: Springer
ISBN: 3319941143
Category : Science
Languages : en
Pages : 197
Get Book Here
Book Description
This book introduces readers to the principles of laser interaction with biological cells and tissues with varying degrees of organization. In addition to considering the problems of biomedical cell diagnostics, and modeling the scattering of laser irradiation of blood cells for biological structures (dermis, epidermis, vascular plexus), it presents an analytic theory based on solving the wave equation for the electromagnetic field. It discusses a range of mathematical modeling topics, including optical characterization of biological tissue with large-scale and small-scale inhomogeneities in the layers; heating blood vessels using laser irradiation on the outer surface of the skin; and thermo-chemical denaturation of biological structures based on the example of human skin. In this second edition, a new electrodynamic model of the interaction of laser radiation with blood cells is presented for the structure of cells and the in vitro prediction of optical properties. The approach developed makes it possible to determine changes in cell size as well as modifications in their internal structures, such as transformation and polymorphism nucleus scattering, which is of interest for cytological studies. The new model is subsequently used to calculate the size distribution function of irregular-shape particles with a variety of forms and structures, which allows a cytological analysis of the observed deviations from normal cells.
Author: Markolf H. Niemz
Publisher: Springer Science & Business Media
ISBN: 3540721916
Category : Medical
Languages : en
Pages : 316
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Book Description
Medical practitioners, scientists and graduate students alike will find this exhaustive survey a vital learning tool. It provides a thorough description of the fundamentals and applications in the field of laser-tissue interactions. Basic concepts such as the optical and thermal properties of tissue, the various types of tissue ablation, and optical breakdown and its related effects are treated in detail. The author pays special attention to mathematical tools (Monte Carlo simulations, the Kubelka-Munk theory etc.) and approved techniques (photodynamic therapy, laser-induced interstitial thermotherapy etc.). A section on applications reviews clinically relevant methods in modern medicine using the latest references.
Author: Markolf Niemz
Publisher: Springer Science & Business Media
ISBN: 3662031930
Category : Science
Languages : en
Pages : 303
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Book Description
Laser--Tissue Interactions provides a thorough description of the fundamentals and applications in this field. Basic conceptions such as optical and thermal properties of tissue, various types of tissue ablation, and optical breakdown with related effects are treated in detail. Special attention is given to mathematical tools (Monte Carlo simulations, Kubelka--Munk theory) and approved techniques (photodynamic therapy, laser-induced interstitial thermotherapy). The part on applications reviews clinically relevant methods in modern medicine according to the latest references. The last chapter includes today's standards of laser safety, with a careful selection of essential guidelines published
Author: Kirill Kulikov
Publisher: Springer Science & Business Media
ISBN: 331901739X
Category : Science
Languages : en
Pages : 155
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Book Description
This book covers the principles of laser interaction with biological cells and tissues of varying degrees of organization. The problems of biomedical diagnostics are considered. Scattering of laser irradiation of blood cells is modeled for biological structures (dermis, epidermis, vascular plexus). An analytic theory is provided which is based on solving the wave equation for the electromagnetic field. It allows the accurate analysis of interference effects arising from the partial superposition of scattered waves. Treated topics of mathematical modeling are: optical characterization of biological tissue with large-scale and small-scale inhomogeneities in the layers, heating blood vessel under laser irradiation incident on the outer surface of the skin and thermo-chemical denaturation of biological structures at the example of human skin.
Author: Kirill Kulikov
Publisher: Springer
ISBN: 9783319343815
Category : Science
Languages : en
Pages : 0
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Book Description
This book covers the principles of laser interaction with biological cells and tissues of varying degrees of organization. The problems of biomedical diagnostics are considered. Scattering of laser irradiation of blood cells is modeled for biological structures (dermis, epidermis, vascular plexus). An analytic theory is provided which is based on solving the wave equation for the electromagnetic field. It allows the accurate analysis of interference effects arising from the partial superposition of scattered waves. Treated topics of mathematical modeling are: optical characterization of biological tissue with large-scale and small-scale inhomogeneities in the layers, heating blood vessel under laser irradiation incident on the outer surface of the skin and thermo-chemical denaturation of biological structures at the example of human skin.
Author: Elharith M. Ahmed
Publisher:
ISBN:
Category : Lasers in medicine
Languages : en
Pages : 178
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Book Description
Since its invention in the early 1960's, the laser has been used as a tool for surgical, therapeutic, and diagnostic purposes. To achieve maximum effectiveness with the greatest margin of safety it is important to understand the mechanisms of light propagation through tissue and how that light affects living cells. Lasers with novel output characteristics for medical and military applications are too often implemented prior to proper evaluation with respect to tissue optical properties and human safety. Therefore, advances in computational models that describe light propagation and the cellular responses to laser exposure, without the use of animal models, are of considerable interest. Here, a physics-based laser-tissue interaction model was developed to predict the spatial and temporal temperature and pressure rise during laser exposure to biological tissues. Our new model also takes into account the dynamic nature of tissue optical properties and their impact on the induced temperature and pressure profiles. The laser-induced retinal damage is attributed to the formation of microbubbles formed around melanosomes in the retinal pigment epithelium (RPE) and the damage mechanism is assumed to be photo-thermal. Selective absorption by melanin creates these bubbles that expand and collapse around melanosomes, destroying cell membranes and killing cells. The Finite Element (FE) approach taken provides suitable ground for modeling localized pigment absorption which leads to a non-uniform temperature distribution within pigmented cells following laser pulse exposure. These hot-spots are sources for localized thermo-elastic stresses which lead to rapid localized expansions that manifest themselves as microbubbles and lead to microcavitations. Model predictions for the interaction of lasers at wavelengths of 193, 694, 532, 590, 1314, 1540, 2000, and 2940 nm with biological tissues were generated and comparisons were made with available experimental data for the retina, cornea or the skin. Good agreement between model and experimental results established the validity of the model.
Author: Ashley J. Welch
Publisher: Springer Science & Business Media
ISBN: 9048188318
Category : Science
Languages : en
Pages : 951
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Book Description
The second edition maintains the standard of excellence established in the first edition, while adjusting the content to reflect changes in tissue optics and medical applications since 1995. The material concerning light propagation now contains new chapters devoted to electromagnetic theory for coherent light. The material concerning thermal laser-tissue interactions contains a new chapter on pulse ablation of tissue. The medical applications section now includes several new chapters on Optical Coherent Tomography, acoustic imaging, molecular imaging, forensic optics and nerve stimulation. A detailed overview is provided of the optical and thermal response of tissue to laser irradiation along with diagnostic and therapeutic examples including fiber optics. Sufficient theory is included in the book so that it is suitable for a one or two semester graduate or for senior elective courses. Material covered includes (1) light propagation and diagnostic application; (2) the thermal response of tissue and therapeutic application; (3) denaturation; and (4) ablation. The theory and applications provide researchers with sufficient detail that this volume will become the primary reference for laser-tissue interactions and medical applications.
Author:
Publisher:
ISBN:
Category : Lasers in biology
Languages : en
Pages : 530
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Book Description
Author:
Publisher:
ISBN:
Category : Laser ablation
Languages : en
Pages : 420
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Book Description
Author:
Publisher:
ISBN:
Category : Laser ablation
Languages : en
Pages : 282
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Book Description
