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Author:
Publisher: World Health Organization
ISBN: 9240025413
Category : Medical
Languages : en
Pages : 91
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Book Description
WHO’s laboratory-based acquired drug resistance survey method yields robust estimates of acquired HIV drug resistance in adults, children and adolescents taking both dolutegravir and non-dolutegravir based regimens by genotyping remnant specimens from routine viral load testing. Results are used to inform programme decision making regarding optimal ART regimens and support evaluation of programme quality with respect to maximizing viral load suppression and minimizing emergence of resistance in people taking ART.
Author:
Publisher: World Health Organization
ISBN: 9240025413
Category : Medical
Languages : en
Pages : 91
Get Book Here
Book Description
WHO’s laboratory-based acquired drug resistance survey method yields robust estimates of acquired HIV drug resistance in adults, children and adolescents taking both dolutegravir and non-dolutegravir based regimens by genotyping remnant specimens from routine viral load testing. Results are used to inform programme decision making regarding optimal ART regimens and support evaluation of programme quality with respect to maximizing viral load suppression and minimizing emergence of resistance in people taking ART.
Author: World Health Organization
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Author: World Health Organization
Publisher: World Health Organization
ISBN: 924006320X
Category : Medical
Languages : en
Pages : 28
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Book Description
Author:
Publisher: World Health Organization
ISBN: 9240035001
Category : Medical
Languages : en
Pages : 60
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Book Description
Author:
Publisher: World Health Organization
ISBN: 9240030565
Category : Medical
Languages : en
Pages : 36
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Book Description
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240076662
Category : Medical
Languages : en
Pages : 30
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Book Description
HIV-1 drug resistance tests may be useful tools for optimizing ART regimens when used in the context of information about viral load, immune and clinical status, adherence practices and available treatment options. Several types of drug resistance tests are available, either as commercial kits or based on published methods for in-house assays. The target product profile for HIV drug resistance tests in low- and middle-income countries: Africa is designed to guide the development of new HIV drug resistance tests in the era of dolutegravir-based antiretroviral therapy (ART) and to facilitate the evaluation of the suitability of currently available HIV drug resistance tests for specific applications. The target product profiles focus on the new-term future for available ART regimens and their use and anticipates an innovate test that will meet the projected demand.
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240086315
Category : Medical
Languages : en
Pages : 46
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Book Description
This brief report summarizes recent information on HIV drug resistance (HIVDR) in the era of integrase-strand transfer inhibitors (INSTI) for HIV prevention and treatment. In this report, WHO documents high levels of HIV viral load suppression (>90%) in populations receiving dolutegravir (DTG)-containing antiretroviral therapy (ART). However, recent observational data reveal that HIVDR to DTG is emerging at levels exceeding those observed in clinical trials. Few countries have reported people not achieving viral suppression while receiving DTG-containing ART. However, amongst the surveys reported, levels of DTG resistance ranged from 3.9% to 8.6%, with levels as high as 19.6% observed among highly treatment-experienced people who transitioned to a DTG-containing ART while having high HIV viral loads. Levels of observed DTG resistance in real world populations receiving ART appear to be higher than anticipated from clinical trials. WHO recommends that countries routinely implement standardised surveillance of HIVDR to follow the prevalence and patterns of resistance among people not achieving suppressed viral load. The use of long acting cabotegravir (CAB-LA) for pre-exposure prophylaxis (PrEP) greatly reduces the risk of acquiring HIV. However, INSTI resistance has been observed in some cases with recent CAB-LA exposure, and delayed detection and confirmation of HIV infection can increase the risk of selection of INSTI drug resistance–associated mutations. Despite the possible risk, the roll-out of CAB-LA for PrEP should not be hindered. Scale-up of PrEP should be accompanied by standardized surveillance of drug resistance among people testing positive for HIV while receiving PrEP.
Author:
Publisher: World Health Organization
ISBN: 9240009426
Category : Medical
Languages : en
Pages : 72
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Book Description
Author:
Publisher: World Health Organization
ISBN: 924003854X
Category : Medical
Languages : en
Pages : 22
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Book Description
Author:
Publisher: World Health Organization
ISBN: 9240038604
Category : Medical
Languages : en
Pages : 138
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Book Description
