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Author: K. Abe
Publisher: Springer Science & Business Media
ISBN: 1461595436
Category : Medical
Languages : en
Pages : 648
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Book Description
The physiological and pathological significance of the kallikrein-kinin system was recently explored extensively, resulting in a rapid accumulation of information regarding their potential importance. This publication provides an integrated picture of the latest information on the kallikrein kinin system. It contains contributions from morphologists, geneticists, biochemists, pharmacologists, physiologists, and clinicians. The Fifth International Kinin Congress (Nov. 29-Dec. 3, 1987) provided a forum for the exchange of information and ideas on the kallikrein-kinin system. The participation of more than 350 scientists from 23 countries reflects the widespread interest and international scope of research activity in the physiological and pathological functions of the kallikrein-kinin system. A total of 275 papers including posters were presented, attesting to the unquestioned success of this Congress. These proceedings, in two volumes, contain the collective studies presented, studies of high scientific standard that provoked stimulating and fruitful discussions. Also included in these volumes are the two plenary lectures presented by Dr. H.A. Margolius (USA) and Dr. S. Nakanishi (Japan). During the last decade our knowledge of the role of the kallikrein kinin system in health and disease has been greatly advanced by the develop ment of antagonists to bradykinin and the introduction to clinical practice of converting enzyme inhibitors. Symposia on converting enzyme and on recent advances in research on the kallikrein-kinin system are included in the proceedings.
Author: K. Abe
Publisher: Springer Science & Business Media
ISBN: 1461595436
Category : Medical
Languages : en
Pages : 648
Get Book Here
Book Description
The physiological and pathological significance of the kallikrein-kinin system was recently explored extensively, resulting in a rapid accumulation of information regarding their potential importance. This publication provides an integrated picture of the latest information on the kallikrein kinin system. It contains contributions from morphologists, geneticists, biochemists, pharmacologists, physiologists, and clinicians. The Fifth International Kinin Congress (Nov. 29-Dec. 3, 1987) provided a forum for the exchange of information and ideas on the kallikrein-kinin system. The participation of more than 350 scientists from 23 countries reflects the widespread interest and international scope of research activity in the physiological and pathological functions of the kallikrein-kinin system. A total of 275 papers including posters were presented, attesting to the unquestioned success of this Congress. These proceedings, in two volumes, contain the collective studies presented, studies of high scientific standard that provoked stimulating and fruitful discussions. Also included in these volumes are the two plenary lectures presented by Dr. H.A. Margolius (USA) and Dr. S. Nakanishi (Japan). During the last decade our knowledge of the role of the kallikrein kinin system in health and disease has been greatly advanced by the develop ment of antagonists to bradykinin and the introduction to clinical practice of converting enzyme inhibitors. Symposia on converting enzyme and on recent advances in research on the kallikrein-kinin system are included in the proceedings.
Author:
Publisher: Springer
ISBN: 9783642673030
Category : Medical
Languages : en
Pages : 820
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Book Description
Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely complex and intricate inter actions in blood. Directly or indirectly, kallikrein and kinins affect the coagulation of blood, the activation of complement, and the generation of angiotensin. Kinins release or modulate the actions of other agents, including prostaglandins, histamine, and catecholamines. Inhibitors of kallikrein or kininase II are employed, for example, in extracorporeal circulation or in hypertension. Kallikrein, kinins, and kininases, present in urine, were described first in 1925 and 1954, but have been ignored for decades. These substances are now studied extensively because of their possible role in blood pressure regulation. The evidence that kinins have a metabolic function is also increasing. The abundance of active components of the system in genital organs suggests a role in the fertilization process. The book is organized into chapters which bear upon these issues.
Author: Michael Bader
Publisher: Walter de Gruyter
ISBN: 311025235X
Category : Science
Languages : en
Pages : 389
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Book Description
This handbook of kinin biology and biochemistry covers the current knowledge of kinins, a family of peptides involved in numerous physiological and pathophysiological processes. Recent publications have shown that the kinin system is highly relevant in a variety of disease states such as diabetes, multiple sclerosis and traumatic injuries. Furthermore, the first drug targeting system has just been approved for clinical use. The goal of this book is to provide advanced students and researchers a basic understanding of the kinin system and its role within the various organ systems. The authors of this book are experts in their fields, including a Nobel Laureate.
Author: Lowell Greenbaum
Publisher: Springer Science & Business Media
ISBN: 146845143X
Category : Medical
Languages : en
Pages : 569
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Book Description
Scientists from 25 countries came together at the Hyatt Regency Hotel on October 21-25, 1984, for the 4th International Kinin Congress in the beautiful city of Savannah, Georgia. Many of the delegates enjoyed southern hospitality for the first time. The friendly city with its streets lined with the Live Oak Tree (symbol of the Congress), the balmy weather, and the excellent facilities of the hotel set the stage for scientific events and exchange that proved so successful. The organ ization of the meeting was the result of many hours, days and weeks of effort by many, including from Augusta Drs. James H. Sutherland, John Catravas, William Davis, Jr. , and Hiroshi Okamoto; and from Charleston, SC, Julie Chao, Ronald Mayfield and Donald Miller. Special thanks go to Ms. Cher Cornett of the Department of Medical Illustration at the Medical College of Georgia for her talent in the design of the logo, as well as the graphics of the program and abstracts. We are indeed indebted to Dr. Paul Brucker, Director of the Division of Health Communi cations at the Medical College of Georgia, for his considerable aid in spending time with us to arrange the programming format and continuity. Ms. Sandra Usry provided very excellent and devoted secretarial help for several years while the Congress was in the making.
Author: Stephen G. Farmer
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 392
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Book Description
Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews: "A delicious masterpiece." --Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins. * Provides a distinctly immunopharmacological approach to the kinin system. * Reviews of the role of kinins in disease and inlcudes data from human studies. * Includes information that is fully up-to-date and comprehensive.
Author: Jagdish N. Sharma
Publisher: Springer
ISBN: 3319066838
Category : Medical
Languages : en
Pages : 203
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Book Description
This volume presents key topics of current interest with regard to several pathophysiological conditions including (a) the basic and clinical aspects of bradykinin receptor antagonists, (b) the kallikrein-kinin pathways in hypertension and diabetes, (c) tissue kallikrein-kinin therapy for hypertension and organ damage, (d) the renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension, (e) the kallikrein-kinin system in diabetes retinopathy, and (f) genetic manipulation and genetic variation of the kallikrein-kinin system and their impacts on cardiovascular and renal disease. Written by internationally reputed scientists, the book provides an essential overview of the latest developments in the field of kinin research, making it a valuable asset for endocrinologists, nephrologists, cardiologists, pharmacologists, physiologists, ophthalmologists and rheumatologists. Furthermore, it is also intended for postgraduate students in the fields of medicine, pharmacy, physiology and pharmacology, and those working at research organizations.
Author: F. Sicuteri
Publisher: Springer Science & Business Media
ISBN: 1468431986
Category : Science
Languages : en
Pages : 638
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Book Description
Author: K. Mikanagi
Publisher: Springer Science & Business Media
ISBN: 1468456733
Category : Science
Languages : en
Pages : 535
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Book Description
These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.
Author: Alberto Amerio
Publisher: Springer Science & Business Media
ISBN: 1468489534
Category : Medical
Languages : en
Pages : 394
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Book Description
In these proceedings of the seminar held in April 1988 in Bari, Italy, forty-one contributions address the effects of drugs and systemic diseases on the kidney. Annotation copyright Book News, Inc. Portland, Or.
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1442
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Book Description
First multi-year cumulation covers six years: 1965-70.
