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Author: Stephen G. Farmer
Publisher: Academic Press
ISBN: 0080542522
Category : Medical
Languages : en
Pages : 371
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Book Description
Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases.* * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.
Author: Stephen G. Farmer
Publisher: Academic Press
ISBN: 0080542522
Category : Medical
Languages : en
Pages : 371
Get Book Here
Book Description
Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases.* * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.
Author: Stefan Offermanns
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 1152
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Book Description
Presents current information on the molecular mechanisms of drug action. Provides 159 essays describing groups of drugs and drug targets. Several essays deal with general principles of pharmacology, such as drug tolerance, drug addiction, or drug metabolism.
Author: David Farrar
Publisher: Elsevier
ISBN: 0857093304
Category : Medical
Languages : en
Pages : 672
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Book Description
Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject. - Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds - Chapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healing - Covers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair
Author:
Publisher: Birkhäuser
ISBN: 9783764385309
Category : Medical
Languages : en
Pages : 0
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Book Description
Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.
Author: N. Back
Publisher: Springer Science & Business Media
ISBN: 1468474391
Category : Science
Languages : en
Pages : 495
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Book Description
The dynamic state of developments within the field of the vasoactive polypeptides is reflected in the continuous series of publications appearing on this topic Thus, the proposal to con o vene another symposium only two years after the 1969 Fiesole Symposium (Plenum Press, 1970) was received enthusiastically and with high expectation. Enthusiasm was based, undoubtedly, in part on meeting together once again in the very pleasant surroundings of Florence with most gracious and enchanting hosts. The 25th International Congress on Physiological Sciences held in Munich the following week also provided the impetus for the organization of this satellite symposium on vasopeptides. However, the accelerated pace of research in the "kinin" field was the major motivating force for the symposium. It was felt necessary to inform each other of the many advances that were taking place in the varied aspects of this specialized but impor tant field o The role of kinins in both physicologic and pathologic processes still remains to be elucidated definitively. Thus, these proceedings contain new and unpublished informa tion on the chemistry, biochemistry, physicology, pharmacology, as well as pathophysiology of vasopeptides. Recent data on &tructure activity relationships of kinin analogues are complemented by a description of radioimmunoassay techniques for kinins, and studies on the site of synthesis of substrates for kinin-forming enzymes.
Author: Abba Kastin
Publisher: Elsevier
ISBN: 0080463797
Category : Science
Languages : en
Pages : 1682
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Book Description
Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.
Author: Michael Bader
Publisher: Walter de Gruyter
ISBN: 311025235X
Category : Science
Languages : en
Pages : 389
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Book Description
This handbook of kinin biology and biochemistry covers the current knowledge of kinins, a family of peptides involved in numerous physiological and pathophysiological processes. Recent publications have shown that the kinin system is highly relevant in a variety of disease states such as diabetes, multiple sclerosis and traumatic injuries. Furthermore, the first drug targeting system has just been approved for clinical use. The goal of this book is to provide advanced students and researchers a basic understanding of the kinin system and its role within the various organ systems. The authors of this book are experts in their fields, including a Nobel Laureate.
Author:
Publisher: Springer
ISBN: 9783642673030
Category : Medical
Languages : en
Pages : 820
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Book Description
Volume XXV of the Handbook of Experimental Pharmacology series entitled "Bradykinin, Kallidin, and Kallikrein" was published in 1970. My aim in editing this volume of the series is not to replace, but to update the 1970 edition. During the decade preceding the publication of Vol. XXV, the existence of kinins and kallikreins gained acceptance, the protein components of the system were purified and characterized and the peptides were synthesized. Even after these accomplish ments, interest in the subject has not abated, but has increased substantially. We have learned a great deal about the role that components of the kallikrein-kinin system play in other systems and about the immensely complex and intricate inter actions in blood. Directly or indirectly, kallikrein and kinins affect the coagulation of blood, the activation of complement, and the generation of angiotensin. Kinins release or modulate the actions of other agents, including prostaglandins, histamine, and catecholamines. Inhibitors of kallikrein or kininase II are employed, for example, in extracorporeal circulation or in hypertension. Kallikrein, kinins, and kininases, present in urine, were described first in 1925 and 1954, but have been ignored for decades. These substances are now studied extensively because of their possible role in blood pressure regulation. The evidence that kinins have a metabolic function is also increasing. The abundance of active components of the system in genital organs suggests a role in the fertilization process. The book is organized into chapters which bear upon these issues.
Author:
Publisher:
ISBN:
Category : Endocrinology
Languages : en
Pages : 544
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Book Description
Author: F. Sicuteri
Publisher: Springer
ISBN: 9781468432008
Category : Science
Languages : en
Pages : 0
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Book Description
At the turn of the present century, researchers recognized that dall1aged tissue released chell1ical agents capable of causing catastrophic effects on the whole organisll1 upon enter ing the blood streall1. Following the discovery of histall1ine, these agents at first seell1ed identifiable with biogenic all1ines. However, very soon after the developll1ent of highly selective antagonists, little responsibility was ascribed to the all1ines, and the tissue factors were wrapped once again in ll1ystery. One can ill1agine perhaps and envy the fascinating ll1Oll1ents experienced by the ?ioneers in the kinin field when they realized that plasll1a had an enorll1OUS store of principles endowed with biologic activity, practically indistinguishable froll1 histall1ine, possessing a cOll1plex turnover and regulated by obscure biochell1icalll1echanisll1s. Like other biochell1ical eras, the era of the kinins was opened by a pioneer stage exceptionally long and exciting. After years of arduous isolation, researchers realized that kinins ll1ay not only be the key to unlocking the ll1ystery of histall1ine -like substance s, but alsoll1ay open the way to understanding other basic problell1s in pathology possibly associated with tissue factors.
