Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies PDF Author: Jeffrey Noebels
Publisher: Oxford University Press
ISBN: 0199842590
Category : Medical
Languages : en
Pages : 1258

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Book Description
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Jasper's Basic Mechanisms of the Epilepsies

Jasper's Basic Mechanisms of the Epilepsies PDF Author: Jeffrey Noebels
Publisher: Oxford University Press
ISBN: 0199842590
Category : Medical
Languages : en
Pages : 1258

Get Book Here

Book Description
H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Current Catalog

Current Catalog PDF Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 690

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Book Description
First multi-year cumulation covers six years: 1965-70.

Kindling 5

Kindling 5 PDF Author: Michael E. Corcoran
Publisher: Springer Science & Business Media
ISBN: 146155375X
Category : Medical
Languages : en
Pages : 507

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Book Description
The last Kindling Conference was organized by Dr. Juhn Wada and held at the Univer sity of British Columbia, Vancouver, B. C. , in 1989. In the intervening years, research on kin dling has proceeded at an explosive pace and significant advances have been made in our understanding of the molecular biological, anatomical, and physiological substrates of kin dling, as well as in our appreciation of the age-dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. In order to review these developments and to provide researchers with an opportunity to in teract face to face and discuss the issues that preoccupy us all, we organized the Fifth Interna tional Conference on Kindling, in Victoria, B. C. , in the summer of 1996. Most of the stalwarts in kindling research were invited, as were a number of investigators whose research on kindling has become prominent in the past few years. We continue to miss the late Graham Goddard, the discoverer of kindling, and were saddened by the recent death of Eric Lothman, a prolific researcher and clinician who would have been a prominent participant. We were deeply disturbed to learn of the death of Frank Morrell, one of the earliest kindlers and an eminent neurologist, who died several months after our conference.

Shemirath Shabbath

Shemirath Shabbath PDF Author: Yehoshau Y. Neuwirth
Publisher: Feldheim Publishers
ISBN: 9781583304945
Category : Religion
Languages : en
Pages : 1444

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Book Description
Applying the laws of Shabbath observance to the innovations of modern life can be daunting and confusing. In response to this challenge, the classic Shemirath Shabbath Kehilchathah was compiled by Rav Yehoshua Y. Neuwirth. The complete English edition covers all aspects of Shabbos observance, with hundreds of practical applications and halachic rulings. This essential edition places proper Sabbath observance within every Jew's grasp. 3-volume gift-boxed set. Sold as a set only. (Individual volumes not sold separately.)

Legislative Documents

Legislative Documents PDF Author: Iowa
Publisher:
ISBN:
Category : Iowa
Languages : en
Pages : 1134

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Book Description
Contains the reports of state departments and officials for the preceding fiscal biennium.

Information Circular

Information Circular PDF Author:
Publisher:
ISBN:
Category : Mine safety
Languages : en
Pages : 432

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Book Description


Cumulated Index Medicus

Cumulated Index Medicus PDF Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1574

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Book Description


I Can Do That! Woodworking Projects

I Can Do That! Woodworking Projects PDF Author: David Thiel
Publisher: Penguin
ISBN: 1440348200
Category : Crafts & Hobbies
Languages : en
Pages : 209

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Book Description
Build quality furniture fast and simple! Beginning woodworkers (or experienced woodworkers who are looking for a weekend project) can accomplish these builds quickly. • Each project requires minimal woodworking experience and only hand and portable power tools--no need for expensive equipment. • These projects use only readily available materials that are easily found at your local home center, saving you lots of time and a few headaches. • Within these pages you'll also find a helpful training manual for choosing and using recommended tools--it's the perfect guide for building your skills as a woodworker. • Learn to build a variety of tasteful and functional items for the home including furniture, shelving and storage.

Sensitization in the Nervous System

Sensitization in the Nervous System PDF Author: Charles D. Barnes
Publisher: CRC Press
ISBN: 104027840X
Category : Science
Languages : en
Pages : 320

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Book Description
Sensitization is a concept of learning and memory that has grown out of experiments on "simple" animals. Interest in sensitization has grown tremendously in the last several years, fueled mainly by evidence of the molecular basis of sensitization in invertebrates on the one hand and the study of cocaine abuse, which produces behavioral sensitization, on the other. Because the rapid advance of information across such a broad range of research areas has made an integrated approach necessary, this volume combines findings on sensitization across the phylogenetic scale.

Epilepsy: A Comprehensive Textbook

Epilepsy: A Comprehensive Textbook PDF Author: Jerome Engel Jr
Publisher: Lippincott Williams & Wilkins
ISBN: 1975105532
Category : Medical
Languages : en
Pages : 10135

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Book Description
Authoritative and updated, Epilepsy: A Comprehensive Textbook, 3rd Edition, contains 365 chapters that cover the full spectrum of relevant topics in biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Written by world-renowned authorities and expertly edited by epileptologists Drs. Jerome Engel, Jr., Solomon L. Moshé, Aristea S. Galanopoulou, John M. Stern, Alexis Arzimanoglou, Jacqueline A. French, Renzo Guerrini, Andres M. Kanner, and Istvan Mody, this three-volume work includes detailed discussions of seizure types and epilepsy syndromes, relationships between physiology and clinical events, psychiatric and medical comorbidities, conditions that could be mistaken for epilepsy, and an increasing range of pharmacologic, surgical, and alternative therapies.