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Author: Hans J Johnson
Publisher: Kitware, Incorporated
ISBN: 9781930934276
Category :
Languages : en
Pages : 250
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Book Description
The ITK Software Guide is divided into two books. This first book provides a general introduction to ITK including instructions for building and installing ITK; introduces the general architecture and design as well as basic system concepts; and explains how to create your own classes, extend the system, and be an active participant in the open-source ITK community. This book is the companion to The ITK Software Guide Book 2: Design and Functionality. ITK is an open-source, cross-platform software toolkit that provides an extensive suite of tools for image analysis. For over a decade, researchers and developers around the world have processed their MRI, CT, ultrasound, PET, fluoroscopy, and microscopy data with ITK. Developed through extreme programming methodologies, ITK employs leading-edge algorithms for registering and segmenting multidimensional data.
Author: Hans J Johnson
Publisher: Kitware, Incorporated
ISBN: 9781930934276
Category :
Languages : en
Pages : 250
Get Book Here
Book Description
The ITK Software Guide is divided into two books. This first book provides a general introduction to ITK including instructions for building and installing ITK; introduces the general architecture and design as well as basic system concepts; and explains how to create your own classes, extend the system, and be an active participant in the open-source ITK community. This book is the companion to The ITK Software Guide Book 2: Design and Functionality. ITK is an open-source, cross-platform software toolkit that provides an extensive suite of tools for image analysis. For over a decade, researchers and developers around the world have processed their MRI, CT, ultrasound, PET, fluoroscopy, and microscopy data with ITK. Developed through extreme programming methodologies, ITK employs leading-edge algorithms for registering and segmenting multidimensional data.
Author: Keith Anthony Ching
Publisher:
ISBN:
Category : Cellular signal transduction
Languages : en
Pages : 216
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Book Description
Expressed in Mast and T-cells/IL-2 Inducible Tyrosine Kinase (Emt/Itk) is a protein tyrosine kinase required for T-cell antigen receptor (TCR)-induced activation and development. A physical interaction between Emt/Itk and the TCR has not been previously described and the mechanism through which Emt/Itk mediates its effector functions is poorly understood. Here, I have studied the role of Emt/Itk in T-cell antigen receptor (TCR) signal transduction by tracking its localization in response to stimulation through the TCR. Furthermore, I have investigated the mechanism of Emt/Itk localization and activation via interactions with the adapter protein LAT. I have utilized laser-scanning confocal microscopy to demonstrate that antibody-mediated engagement of the CD3[epislon]; chain induces the co-localization of Emt/Itk with TCR/CD3 at the plasma membrane. Removal of the Emt/Itk Pleckstrin Homology domain ([delta]PH-Emt/Itk) abrogates the association of the kinase with the cell membrane, as well as its activation-induced co-localization with the TCR complex and subsequent tyrosine phosphorylation. The addition of a membrane localization sequence from Lck to [delta]PH-Emt/Itk restores its co-localization with the TCR but not its activation-induced tyrosine phosphorylation. The data suggest that the PH domain of Emt/Itk can be replaced with another membrane-localization signal without affecting the membrane targeting and activation-induced colocalization of the kinase with the TCR. However, the PH domain is indispensable for the activation-induced tyrosine phosphorylation of the kinase. I also found that the Emt/Itk SH2 domain is critical for transphosphorylation and activation of Emt/Itk catalytic activity. I show that the Emt/Itk SH2 domain is essential for Emt/Itk to form TCR/CD3 inducible Emt/Itk-LAT complexes whereas the SH3 domain and catalytic activity are not required. I also demonstrate that Emt/Itk-LAT complexes are biologically important because Jurkat T-cells with deficient LAT expression (JCaM2) fail to increase Emt/Itk tyrosine phosphorylation upon TCR/CD3 stimulation. Furthermore, I confirm the stimulation dependent clustering of Emt/Itk and LAT with the TCR complex using confocal microscopy. The present data indicate that the Ernt/Itk SH2 domain mediates the formation of a complex with LAT at the TCR which is essential for Emt/Itk activation and function.
Author: Michael A. Brilleslyper
Publisher: American Mathematical Soc.
ISBN: 1614441081
Category : Mathematics
Languages : en
Pages : 373
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Book Description
Research topics in the book include complex dynamics, minimal surfaces, fluid flows, harmonic, conformal, and polygonal mappings, and discrete complex analysis via circle packing. The nature of this book is different from many mathematics texts: the focus is on student-driven and technology-enhanced investigation. Interlaced in the reading for each chapter are examples, exercises, explorations, and projects, nearly all linked explicitly with computer applets for visualization and hands-on manipulation.
Author: Hans J Johnson
Publisher: Kitware, Incorporated
ISBN: 9781930934283
Category :
Languages : en
Pages : 522
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Book Description
The ITK Software Guide is divided into two books. This second book details the toolkit architecture that supports reading and writing of images to files, introduces the most commonly used filters found in ITK, discusses ITK's capabilities for performing image registration, reviews ITK's commonly used segmentation components, and describes ITK's statistics functionalities. This book is the companion to The ITK Software Guide Book 1: Introduction and Development Guidelines. ITK is an open-source, cross-platform software toolkit that provides an extensive suite of tools for image analysis. For over a decade, researchers and developers around the world have processed their MRI, CT, ultrasound, PET, fluoroscopy, and microscopy data with ITK. Developed through extreme programming methodologies, ITK employs leading-edge algorithms for registering and segmenting multidimensional data.
Author: Terry Gander
Publisher: Pen and Sword
ISBN: 1783462027
Category : History
Languages : en
Pages : 277
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Book Description
The 40mm Bofors Gun, first produced in the 1930s, has become one of the most famous artillery pieces of all time. It shows no sign of fading from the defence scene even though, in the second decade of the twenty-first century, it performs in many roles that were not contemplated by its original designers. It has also proved to be so versatile that it is now allied to electronic and other technological marvels that were mere pipe dreams only a few years ago. When the Bofors entered the international defence market, its primary quarry, the military aircraft, was still a slow and fragile machine that could be terminally damaged by a single hit from a 40mm projectile. Terry Gander describes this early period in the gun's development and he shows how, despite recent?increases in target speed and other performance parameters, it can still inflict a one-hit kill on almost any aircraft, helicopter?or guided missile. Perhaps the most astonishing aspect of the story is that the fundamentals of today's Bofors guns remain virtually unchanged from the very first examples to come off the Karlskoga production line in Sweden. In all its forms, the Bofors continues to be a sound, reliable and lethal piece of military hardware that has given good service to gunners all over the world.?Terry Gander's comprehensive account of the history of this remarkable weapon over the course of almost eighty years is fascinating?reading and an invaluable work of reference for military historians and artillery specialists alike. It is the definitive work in the field.??As featured on BBC Radio Guernsey.
Author: Johan Pottier
Publisher: Routledge
ISBN: 113487930X
Category : Social Science
Languages : en
Pages : 234
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Book Description
Throughout the 1980s there have been calls, often from development organizations of global repute, for the incorporation of social science perspectives into the design and management of sustainable development programmes. Practising Development is the first collection to offer first-hand critical assessments of the success and failures found within actual responses to these calls. By combining academic and practical experience from anthropology, development and aid organizations the contributors examine the processes of intervention, the methods by which this intervention can be assessed, and explain the socio-economic and political worlds within which intervention and development evolve.
Author: Ralph A. Bradshaw
Publisher: Academic Press
ISBN: 0080533574
Category : Science
Languages : en
Pages : 2560
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Book Description
The Handbook of Cell Signaling is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The subject matter has been divided into five main parts (each of which is headed by a recognized expert in the field): * Initiation: Extracellular and Membrane Events * Transmission: Effectors and Cytosolic Events * Nuclear Responses: Gene Expression and Translation * Events in Intracellular Compartments * Cell-Cell and Cell-Matrix Interactions Covered in extensive detail, these areas will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Tabular and well-illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field! * Contains approximately 470 articles * Provides well-organized sections on each essential area in signaling * Includes discussion on everything from ligand/receptor interactions to organ/organism responses * Extremely user-friendly
Author: Charles D. Hansen
Publisher: Academic Press
ISBN: 012387582X
Category : Computers
Languages : en
Pages : 1062
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Book Description
A picture can communicate a thousand words ... this book gives new meaning to the phrase!
Author: Alexandru C. Telea
Publisher: CRC Press
ISBN: 1498759793
Category : Computers
Languages : en
Pages : 619
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Book Description
Designing a complete visualization system involves many subtle decisions. When designing a complex, real-world visualization system, such decisions involve many types of constraints, such as performance, platform (in)dependence, available programming languages and styles, user-interface toolkits, input/output data format constraints, integration wi
Author:
Publisher: Elsevier
ISBN: 0128032014
Category : Technology & Engineering
Languages : en
Pages : 4609
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Book Description
Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs
