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Author: International Agency for Research on Cancer
Publisher:
ISBN: 9789283201601
Category :
Languages : en
Pages : 175
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Book Description
This volume of the IARC Monographs provides evaluations of the carcinogenicity of isobutyl nitrite, beta-picoline, methyl acrylate, ethyl acrylate, 2-ethylhexyl acrylate, and trimethylolpropane triacrylate. The four acrylates evaluated are chemicals with a high production volume that are produced worldwide. Methyl acrylate is used in the production of acrylic fibres and fire-retardant fabrics. Ethyl acrylate is one of the principal monomers used worldwide in the production of styrene-based polymers which can be used for medical and dental items. Ethyl acrylate is also used in surface coatings for textiles, paper, leather, and food contact materials, and as a food flavoring agent. 2-Ethylhexyl acrylate is used as a plasticizing co-monomer in the production of resins for pressure-sensitive adhesives, latex paints, reactive diluent/cross-linking agents, textile and leather finishes, and coatings for paper. Trimethylolpropane triacrylate, available as a technical-grade product that also contains incomplete reaction products, is used primarily in production of ultraviolet-curable inks, paint additives, coatings, and adhesives. Beta-Picoline, a methyl pyridine, is widely used as a starting material for pesticides (e.g. chlorpyrifos) and pharmaceuticals (e.g. vitamin B3). It is also used as a flavoring substance in foods and beverages. Isobutyl nitrite is used as an intermediate in the syntheses of solvents and fuels and exposures also occur through its use as a recreational drug. Exposure to all six agents considered may occur in the general population as well as in various occupational settings. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure to these agents.
Author: International Agency for Research on Cancer
Publisher:
ISBN: 9789283201601
Category :
Languages : en
Pages : 175
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Book Description
This volume of the IARC Monographs provides evaluations of the carcinogenicity of isobutyl nitrite, beta-picoline, methyl acrylate, ethyl acrylate, 2-ethylhexyl acrylate, and trimethylolpropane triacrylate. The four acrylates evaluated are chemicals with a high production volume that are produced worldwide. Methyl acrylate is used in the production of acrylic fibres and fire-retardant fabrics. Ethyl acrylate is one of the principal monomers used worldwide in the production of styrene-based polymers which can be used for medical and dental items. Ethyl acrylate is also used in surface coatings for textiles, paper, leather, and food contact materials, and as a food flavoring agent. 2-Ethylhexyl acrylate is used as a plasticizing co-monomer in the production of resins for pressure-sensitive adhesives, latex paints, reactive diluent/cross-linking agents, textile and leather finishes, and coatings for paper. Trimethylolpropane triacrylate, available as a technical-grade product that also contains incomplete reaction products, is used primarily in production of ultraviolet-curable inks, paint additives, coatings, and adhesives. Beta-Picoline, a methyl pyridine, is widely used as a starting material for pesticides (e.g. chlorpyrifos) and pharmaceuticals (e.g. vitamin B3). It is also used as a flavoring substance in foods and beverages. Isobutyl nitrite is used as an intermediate in the syntheses of solvents and fuels and exposures also occur through its use as a recreational drug. Exposure to all six agents considered may occur in the general population as well as in various occupational settings. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure to these agents.
Author: P A CARSON
Publisher: Elsevier
ISBN: 008052379X
Category : Technology & Engineering
Languages : en
Pages : 389
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Book Description
Summarizes core information for quick reference in the workplace, using tables and checklists wherever possible. Essential reading for safety officers, company managers, engineers, transport personnel, waste disposal personnel, environmental health officers, trainees on industrial training courses and engineering students. This book provides concise and clear explanation and look-up data on properties, exposure limits, flashpoints, monitoring techniques, personal protection and a host of other parameters and requirements relating to compliance with designated safe practice, control of hazards to people's health and limitation of impact on the environment. The book caters for the multitude of companies, officials and public and private employees who must comply with the regulations governing the use, storage, handling, transport and disposal of hazardous substances. Reference is made throughout to source documents and standards, and a Bibliography provides guidance to sources of wider ranging and more specialized information. Dr Phillip Carson is Safety Liaison and QA Manager at the Unilever Research Laboratory at Port Sunlight. He is a member of the Institution of Occupational Safety and Health, of the Institution of Chemical Engineers' Loss Prevention Panel and of the Chemical Industries Association's `Exposure Limits Task Force' and `Health Advisory Group'. Dr Clive Mumford is a Senior Lecturer in Chemical Engineering at the University of Aston and a consultant. He lectures on several courses of the Certificate and Diploma of the National Examining Board in Occupational Safety and Health. [Given 5 star rating] - Occupational Safety & Health, July 1994 - Loss Prevention Bulletin, April 1994 - Journal of Hazardous Materials, November 1994 - Process Safety & Environmental Prot., November 1994
Author: Florencio Zaragoza Dörwald
Publisher: John Wiley & Sons
ISBN: 3527604987
Category : Science
Languages : en
Pages : 389
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Book Description
Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium-Catalyzed C-C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates
Author: Eric F.V. Scriven
Publisher: Academic Press
ISBN: 0123852366
Category : Science
Languages : en
Pages : 583
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Book Description
Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more. - Reviews tried and tested practical methods to help the reader select the best method for their research - Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative - Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on
Author: Charles J. Baker
Publisher: Jones & Bartlett Learning
ISBN: 9780763734084
Category : Education
Languages : en
Pages : 512
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Book Description
Hazardous materials are an inevitable part of every fire fighter's job. Knowing how to operate safely and take the necessary precautions is crucial. The Fire Fighter's Handbook of Hazardous Materials, Seventh Edition is a quick and simple reference book of hazardous substances that fire fighters are likely to encounter.
Author: L. Bretherick
Publisher: Elsevier
ISBN: 1483162508
Category : Technology & Engineering
Languages : en
Pages : 2058
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Book Description
Bretherick's Handbook of Reactive Chemical Hazards, Fourth Edition, has been prepared and revised to give access to a wide and up-to-date selection of documented information to research students, practicing chemists, safety officers, and others concerned with the safe handling and use of reactive chemicals. This will allow ready assessment of the likely potential for reaction hazards which may be associated with an existing or proposed chemical compound or reaction system. A secondary, longer-term purpose is to present the information in a way which will, as far as possible, bring out the causes of, and interrelationships between, apparently disconnected facts and incidents. This handbook includes all information which had become available to the author by April 1989 on the reactivity hazards of individual elements or compounds, either alone or in combination. It begins with an introductory chapter that provides an overview of the complex subject of reactive chemical hazards, drawing attention to the underlying principles and to some practical aspects of minimizing such hazards. This is followed by two sections: Section 1 provides detailed information on the hazardous properties of individual chemicals, either alone or in combination with other compounds; the entries in Section 2 are of two distinct types. The first type of entry gives general information on the hazardous behavior of some recognizably discrete classes or groups of the 4,600 or so individual compounds for which details are given in Section 1. The second type of entry concerns reactive hazard topics, techniques, or incidents which have a common theme or pattern of behavior involving compounds of several different groups, so that no common structural feature exists for the compounds involved.
Author: United States Pharmacopeial Convention
Publisher:
ISBN: 9781936424443
Category :
Languages : en
Pages :
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Book Description
Author: Qayyum Husain
Publisher: Springer Nature
ISBN: 3030250237
Category : Science
Languages : en
Pages : 341
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Book Description
This book introduces readers to industrially important enzymes and discusses in detail their structures and functions, as well as their manifold applications. Due to their selective biocatalytic capabilities, enzymes are used in a broad range of industries and processes. The book highlights selected enzymes and their applications in agriculture, food processing and discoloration, as well as their role in biomedicine. In turn, it discusses biochemical engineering strategies such as enzyme immobilization, metabolic engineering, and cross-linkage of enzyme aggregates, and critically weighs their pros and cons. Offering a wealth of information, and stimulating further research by presenting new concepts on enzymatic catalytic functions in basic and applied contexts, the book represents a valuable asset for researchers from academia and industry who are engaged in biochemical engineering, microbiology and biotechnology.
Author:
Publisher:
ISBN:
Category : Chemicals
Languages : en
Pages : 422
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Book Description
Author: Daniel Lednicer
Publisher: John Wiley & Sons
ISBN: 0470180668
Category : Science
Languages : en
Pages : 288
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Book Description
The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.
