Ion-Solvent Interaction of Water Soluble Drugs in Binary Solvent Systems PDF Download
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Author: Dr. Prakash Chandra Pal
Publisher: Newredmars Education Pvt Ltd
ISBN: 8193404440
Category : Science
Languages : en
Pages : 91
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Book Description
At the outset, the author of the book welcomes his supervisor Prof. Dr. Smrutiprava Das who have joined me as coauthors of this text, a credit which would have been given earlier to them as they were helping in a latent way in the evolution of the book for the past six years. Six years have elapsed on the intellectual journey of writing a PhD thesis e-book in title “IonSolvent Interaction of Water Soluble Drugs in Binary Solvent Systems” in subject of chemistry. As chemical kinetics is growing at a dazzling pace, this edition has been demanding in a different way. In this 1 st edition, the book has been thoroughly described, enlarged and updated with chemical kinetics of ion-solvent interaction of water soluble drugs in binary solvent systems. Above and over all, this time the book has been presented in multicolour edition with profuse colour illustrations so as to increase its clarity, understand ability and legibility, especially of the diagrams. It is hoped that the present book, enlarged multicolour form, would serve in a still better way, the authors are keenly desirous of. Gratitude is expressed to the students and teachers, both from India and abroad, who have sent in their valuable suggestions which have been given due consideration. We are sincerely thankful to our publisher, Newredmars Education. We are also deeply indebted to my guide Prof. Dr. Smrutiprava Das for her sustained support of this endeavour from its inception; her wisdom has made all the difference. In fact, we are grateful to department of chemistry, Ravenshaw University, Odisha, India for their patience, buoyancy and encouragement of this venture which was more arduous than anticipated. Healthy criticism and suggestions for further improvement of the book are solicited.
Author: Dr. Prakash Chandra Pal
Publisher: Newredmars Education Pvt Ltd
ISBN: 8193404440
Category : Science
Languages : en
Pages : 91
Get Book Here
Book Description
At the outset, the author of the book welcomes his supervisor Prof. Dr. Smrutiprava Das who have joined me as coauthors of this text, a credit which would have been given earlier to them as they were helping in a latent way in the evolution of the book for the past six years. Six years have elapsed on the intellectual journey of writing a PhD thesis e-book in title “IonSolvent Interaction of Water Soluble Drugs in Binary Solvent Systems” in subject of chemistry. As chemical kinetics is growing at a dazzling pace, this edition has been demanding in a different way. In this 1 st edition, the book has been thoroughly described, enlarged and updated with chemical kinetics of ion-solvent interaction of water soluble drugs in binary solvent systems. Above and over all, this time the book has been presented in multicolour edition with profuse colour illustrations so as to increase its clarity, understand ability and legibility, especially of the diagrams. It is hoped that the present book, enlarged multicolour form, would serve in a still better way, the authors are keenly desirous of. Gratitude is expressed to the students and teachers, both from India and abroad, who have sent in their valuable suggestions which have been given due consideration. We are sincerely thankful to our publisher, Newredmars Education. We are also deeply indebted to my guide Prof. Dr. Smrutiprava Das for her sustained support of this endeavour from its inception; her wisdom has made all the difference. In fact, we are grateful to department of chemistry, Ravenshaw University, Odisha, India for their patience, buoyancy and encouragement of this venture which was more arduous than anticipated. Healthy criticism and suggestions for further improvement of the book are solicited.
Author: Maire Catiriona Mairtin
Publisher:
ISBN:
Category :
Languages : en
Pages : 187
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Book Description
Author: Ron Liu
Publisher: CRC Press
ISBN: 1351646826
Category : Medical
Languages : en
Pages : 781
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Book Description
Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.
Author: National Institutes of Health (U.S.). Division of Research Grants
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 850
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1258
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Book Description
Author: Patrick Augustijns
Publisher: Springer Science & Business Media
ISBN: 0387691545
Category : Medical
Languages : en
Pages : 466
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Book Description
Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to generate both a practical handbook as well as a reference allowing the reader to make effective decisions concerning the use of solvents and solvent systems. To this end, the monograph was created by inviting recognized experts from a number of fields to author relevant sections. Specifically, 15 chapters have been designed covering the theoretical background of solubility, the effect of ionic equilibria and pH on solubilization, the use of solvents to effect drug substance crystallization and polymorph selection, the use of solvent systems in high throughput screening and early discovery, solvent use in preformulation, the use of solvents in bio-relevant dissolution and permeation experiments, solvents and their use as toxicology vehicles, solubilizing media and excipients in oral and parenteral formulation development, specialized vehicles for protein formulation and solvent systems for topical and pulmonary drug administration. The chapters are organized such that useful decision trees are included together with the scientific underpinning for their application. In addition, trends in the use of solvent systems and a balance of current views make this monograph useful to both the novice and experienced researcher and to scientists at all developmental stages from early discovery to late pharmaceutical operations.
Author: Johannes Francois Coetzee
Publisher:
ISBN:
Category : Solution (Chemistry)
Languages : en
Pages : 676
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Book Description
Author: Abolghasem Jouyban
Publisher: CRC Press
ISBN: 1439804885
Category : Medical
Languages : en
Pages : 554
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Book Description
Aqueous solubility is one of the major challenges in the early stages of drug discovery. One of the most common and effective methods for enhancing solubility is the addition of an organic solvent to the aqueous solution. Along with an introduction to cosolvency models, the Handbook of Solubility Data for Pharmaceuticals provides an extensive datab
Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 2730
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Book Description
Author: Alex A. Adjei
Publisher: Elsevier
ISBN: 0080537758
Category : Medical
Languages : en
Pages : 478
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Book Description
Novel Anticancer Agents offers pertinent basic science information on strategies used for the rational design and discovery of novel anticancer agents, and, in addition, translational studies involving clinical trial design and execution with these novel, mostly cytostatic agents. This book covers basic science strategies that are being used in drug discovery and preclinical evaluation focused on novel molecular targets, as well as clinical trial methodology including clinical pharmacokinetics and imaging to address issues of efficacy evaluation of the new, relatively non-cytotoxic anticancer agents. At present, there is no book that provides such an integration of basic and clinical studies of novel anticancer agents, covering both drug discovery and translational research extensively. Addresses the critical issues involved in the development of novel agents for cancer therapy by experts in the field Presents drug discovery strategies Discusses regulatory issues surrounding drug development
