Introductory Review on Sirtuins in Biology, Aging, and Disease PDF Download
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Author: Leonard Guarente
Publisher: Academic Press
ISBN: 012813500X
Category : Science
Languages : en
Pages : 222
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Book Description
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses
Author: Leonard Guarente
Publisher: Academic Press
ISBN: 012813500X
Category : Science
Languages : en
Pages : 222
Get Book Here
Book Description
Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses
Author: R. R. Tatlock
Publisher: Read Books Ltd
ISBN: 147338981X
Category : Art
Languages : en
Pages : 347
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Book Description
Spanish Art - An Introductory Review of Architecture, Painting, Sculpture, Textiles, Ceramics, Woodwork, Metalwork.' by Robert Rattray Tatlock. Tatlock was an art critic and historian. He was born in Glasgow and educated at the Glasgow Academy, Glasgow School of Art and Royal Technical College where he studied art. During the First World War he served with the British Red Cross in France and Russia, and in 1917 he was attached to the British Adriatic Mission.
Author: Paul Miller
Publisher: MIT Press
ISBN: 0262347563
Category : Science
Languages : en
Pages : 405
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Book Description
A textbook for students with limited background in mathematics and computer coding, emphasizing computer tutorials that guide readers in producing models of neural behavior. This introductory text teaches students to understand, simulate, and analyze the complex behaviors of individual neurons and brain circuits. It is built around computer tutorials that guide students in producing models of neural behavior, with the associated Matlab code freely available online. From these models students learn how individual neurons function and how, when connected, neurons cooperate in a circuit. The book demonstrates through simulated models how oscillations, multistability, post-stimulus rebounds, and chaos can arise within either single neurons or circuits, and it explores their roles in the brain. The book first presents essential background in neuroscience, physics, mathematics, and Matlab, with explanations illustrated by many example problems. Subsequent chapters cover the neuron and spike production; single spike trains and the underlying cognitive processes; conductance-based models; the simulation of synaptic connections; firing-rate models of large-scale circuit operation; dynamical systems and their components; synaptic plasticity; and techniques for analysis of neuron population datasets, including principal components analysis, hidden Markov modeling, and Bayesian decoding. Accessible to undergraduates in life sciences with limited background in mathematics and computer coding, the book can be used in a “flipped” or “inverted” teaching approach, with class time devoted to hands-on work on the computer tutorials. It can also be a resource for graduate students in the life sciences who wish to gain computing skills and a deeper knowledge of neural function and neural circuits.
Author: Miguel Morales
Publisher: Manning Publications
ISBN: 1617295450
Category : Computers
Languages : en
Pages : 470
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Book Description
Grokking Deep Reinforcement Learning uses engaging exercises to teach you how to build deep learning systems. This book combines annotated Python code with intuitive explanations to explore DRL techniques. You’ll see how algorithms function and learn to develop your own DRL agents using evaluative feedback. Summary We all learn through trial and error. We avoid the things that cause us to experience pain and failure. We embrace and build on the things that give us reward and success. This common pattern is the foundation of deep reinforcement learning: building machine learning systems that explore and learn based on the responses of the environment. Grokking Deep Reinforcement Learning introduces this powerful machine learning approach, using examples, illustrations, exercises, and crystal-clear teaching. You'll love the perfectly paced teaching and the clever, engaging writing style as you dig into this awesome exploration of reinforcement learning fundamentals, effective deep learning techniques, and practical applications in this emerging field. Purchase of the print book includes a free eBook in PDF, Kindle, and ePub formats from Manning Publications. About the technology We learn by interacting with our environment, and the rewards or punishments we experience guide our future behavior. Deep reinforcement learning brings that same natural process to artificial intelligence, analyzing results to uncover the most efficient ways forward. DRL agents can improve marketing campaigns, predict stock performance, and beat grand masters in Go and chess. About the book Grokking Deep Reinforcement Learning uses engaging exercises to teach you how to build deep learning systems. This book combines annotated Python code with intuitive explanations to explore DRL techniques. You’ll see how algorithms function and learn to develop your own DRL agents using evaluative feedback. What's inside An introduction to reinforcement learning DRL agents with human-like behaviors Applying DRL to complex situations About the reader For developers with basic deep learning experience. About the author Miguel Morales works on reinforcement learning at Lockheed Martin and is an instructor for the Georgia Institute of Technology’s Reinforcement Learning and Decision Making course. Table of Contents 1 Introduction to deep reinforcement learning 2 Mathematical foundations of reinforcement learning 3 Balancing immediate and long-term goals 4 Balancing the gathering and use of information 5 Evaluating agents’ behaviors 6 Improving agents’ behaviors 7 Achieving goals more effectively and efficiently 8 Introduction to value-based deep reinforcement learning 9 More stable value-based methods 10 Sample-efficient value-based methods 11 Policy-gradient and actor-critic methods 12 Advanced actor-critic methods 13 Toward artificial general intelligence
Author: United States. Bureau of Foreign Commerce
Publisher:
ISBN:
Category :
Languages : en
Pages : 294
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Book Description
Author: Marcel Danesi
Publisher: Rowman & Littlefield
ISBN: 1442217839
Category : Language Arts & Disciplines
Languages : en
Pages : 287
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Book Description
Popular Culture: Introductory Perspectives seeks to define pop culture by exploring the ways that it fulfills our human desire for meaning.The second edition investigates current contexts for popular culture, including the rise of the digital global village through new technology and offers up-to-date examples that connect with today's students."
Author: Preston Norton
Publisher: Little, Brown Books for Young Readers
ISBN: 1484798368
Category : Young Adult Fiction
Languages : en
Pages : 343
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Book Description
Two sworn enemies suddenly switch bodies in this witty and heartfelt novel of romantic relationships, gender identity, and the joy of being yourself. Ezra Slevin is an anxious, neurotic insomniac who spends his nights questioning his place in the universe and his days obsessing over Imogen, a nerdy girl with gigantic eyebrows and a heart of gold. For weeks, Ezra has been working up the courage to invite Imogen to prom. The only problem is Imogen's protective best friend, Wynonna Jones. Wynonna has blue hair, jams to '80s rock, and has made a career out of tormenting Ezra for as long as he can remember. Then, on the night of a total solar eclipse, something strange happens to Ezra and Wynonna, and they wake up in each other's bodies. Not only that, they begin randomly swapping back and forth every day! Ezra soon discovers Wynonna's huge crush on his best friend, Holden, a five-foot-nothing girl magnet with anger management problems. With no end to their curse in sight, Ezra makes Wynonna a proposition: While swapping bodies, he will help her win Holden's heart, but only if she helps him woo Imogen. Forming an uneasy alliance, Ezra and Wynonna embark on a collision course of mistaken identity, hurt feaelings, embarrassing bodily functions, and a positively byzantine production of Twelfth Night. Ezra wishes he could be more like Wynonna's badass version of Ezra -- but he also realizes he feels more like himself while being Wynonna than he has in a long time. Wildly entertaining and deeply heartfelt, Where I End and You Begin is a brilliant, unapologetic exploration of what it means to be your best self.
Author: V. K . Balakrishnan
Publisher: Courier Corporation
ISBN: 0486140385
Category : Mathematics
Languages : en
Pages : 260
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Book Description
This concise, undergraduate-level text focuses on combinatorics, graph theory with applications to some standard network optimization problems, and algorithms. More than 200 exercises, many with complete solutions. 1991 edition.
Author: Alan S. Horowitz
Publisher: Springer Science & Business Media
ISBN: 3642651119
Category : Science
Languages : en
Pages : 314
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Book Description
This is a book for beginners. Not geological beginners, because an introductory course in paleontology and some knowledge of the petrographic microscope is assumed, but for beginners in the study of the petrography of fossil constituents in sedimentary rocks. Fossils are studied for various reasons: 1) to provide chron ologic (time) frameworks, 2) to delineate rock units and ancient environments, or 3) to understand the past development (evolu tion) of living plants and animals. All of these uses may be at tained through petrographic studies of thin sections of fossils embedded in sedimentary rocks. Some knowledge of the appear ance of fossils in thin section is also fundamental for general stratigraphic studies, biofacies analyses, and is even useful in studying some metamorphic rocks. Commonly, fossils are essen tial for the delineation of carbonate rock types (facies or bio facies). We have written this book for sedimentary petrologists and stratigraphers, who routinely encounter fossils as part of their studies but who are not specialists in paleontology, and for students who are seeking a brief review and an introduction to the literature of the petrography of fossiliferous sedimentary rocks. Although experienced paleontologists may be appalled by the many generalized statements on size, shape, and principal fossil characters recited herein, we counter that we have had some success in introducing non-paleontologically oriented geologists to the use and identification of fossil constituents without using excessive paleontological terminology and detailed systematics.
Author: Amy Shell-Gellasch
Publisher: JHU Press
ISBN: 1421417294
Category : Mathematics
Languages : en
Pages : 553
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Book Description
An engaging new approach to teaching algebra that takes students on a historical journey from its roots to modern times. This book’s unique approach to the teaching of mathematics lies in its use of history to provide a framework for understanding algebra and related fields. With Algebra in Context, students will soon discover why mathematics is such a crucial part not only of civilization but also of everyday life. Even those who have avoided mathematics for years will find the historical stories both inviting and gripping. The book’s lessons begin with the creation and spread of number systems, from the mathematical development of early civilizations in Babylonia, Greece, China, Rome, Egypt, and Central America to the advancement of mathematics over time and the roles of famous figures such as Descartes and Leonardo of Pisa (Fibonacci). Before long, it becomes clear that the simple origins of algebra evolved into modern problem solving. Along the way, the language of mathematics becomes familiar, and students are gradually introduced to more challenging problems. Paced perfectly, Amy Shell-Gellasch and J. B. Thoo’s chapters ease students from topic to topic until they reach the twenty-first century. By the end of Algebra in Context, students using this textbook will be comfortable with most algebra concepts, including • Different number bases • Algebraic notation • Methods of arithmetic calculation • Real numbers • Complex numbers • Divisors • Prime factorization • Variation • Factoring • Solving linear equations • False position • Solving quadratic equations • Solving cubic equations • nth roots • Set theory • One-to-one correspondence • Infinite sets • Figurate numbers • Logarithms • Exponential growth • Interest calculations
