The Intervertebral Disc PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download The Intervertebral Disc PDF full book. Access full book title The Intervertebral Disc by Irving M. Shapiro. Download full books in PDF and EPUB format.
Author: Irving M. Shapiro
Publisher: Springer Science & Business Media
ISBN: 3709115353
Category : Medical
Languages : en
Pages : 440
Get Book Here
Book Description
The intervertebral disc is a complex structure that separates opposing vertebrae, permits a wide range of motion, and accommodates high biomechanical forces. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, the first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies to mitigate the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is devoted to approaches to model normal development and elucidate the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques. The book bridges the gap between the basic and clinical sciences; the target audience includes basic scientists, orthopaedists and neurologists, while at the same time appealing to the needs of graduate students, medical students, interns and fellows.
Author: Irving M. Shapiro
Publisher: Springer Science & Business Media
ISBN: 3709115353
Category : Medical
Languages : en
Pages : 440
Get Book Here
Book Description
The intervertebral disc is a complex structure that separates opposing vertebrae, permits a wide range of motion, and accommodates high biomechanical forces. Disc degeneration leads to a loss of function and is often associated with excruciating pain. Written by leading scientists and clinicians, the first part of the book provides a review of the basic biology of the disc in health and disease. The second part considers strategies to mitigate the effects of disc degeneration and discusses the possibility of engineering replacement tissues. The final section is devoted to approaches to model normal development and elucidate the pathogenesis of degenerative disc disease using animal, organ and cell culture techniques. The book bridges the gap between the basic and clinical sciences; the target audience includes basic scientists, orthopaedists and neurologists, while at the same time appealing to the needs of graduate students, medical students, interns and fellows.
Author: Roger Haertl
Publisher: Thieme
ISBN: 1626232512
Category : Medical
Languages : en
Pages : 448
Get Book Here
Book Description
Top Experts Share Clinical Insights on Biological Interventions for Spine-Related Disease Although there have been significant advancements in minimally invasive spinal surgery techniques in the last few decades, optimal outcomes for chronic low back pain remain elusive. A number of promising clinical trials have been conducted using tissue engineering and biological interventions for disc degeneration. Written by renowned innovators, this is the first book that covers implementation of these groundbreaking approaches for disc disease. The text begins with key fundamentals including anatomy and physiology, pathophysiology, imaging and biomechanics to delineate healthy versus diseased spine. Subsequent sections discuss treatment strategies, research findings, and future developments. Throughout each chapter, renowned spine surgeons and scientists share clinical pearls gleaned from hands-on experience. Key Highlights The current state of the art in biological and tissue engineering procedures for spinal disorders Treatment methodologies including nucleus replacement and repair, annulus fibrosus repair, total disc transplantation, and mechanical total disc replacement Innovative treatment strategies for disc regeneration, such as genes and proteins Growth factors including platelet-rich plasma (PRP), which has shown promise for the stimulation and acceleration of bone and soft tissue healing Cell-based therapy for spinal disc regeneration and repair including the use of stem cells and chondrocytes In-depth discussion of research including animal versus human model, in-vitro, and a summary of biologic clinical trials This is a must-have resource for trainee and practicing orthopaedic surgeons and neurosurgeons who treat patients for spine-related conditions. It is essential reading for all clinicians who have an interest in cutting-edge tissue engineering and biological treatment interventions.
Author: Benjamin Gantenbein
Publisher: Mdpi AG
ISBN: 9783036527543
Category :
Languages : en
Pages : 138
Get Book Here
Book Description
This book provides a brief snapshot of recent research on the subject of intervertebral disc degeneration and how this specific organ could be regenerated. It provides stimuli to the reader in representing research from different angles in this cross-disciplinary field of spine surgeons, mechanical engineers and biologists. In particular, it is instructive as to how disc herniations could be successfully induced in vitro and, also, to how novel cell-based therapies using rare autochthonous stem cells could potentially be used in the future.
Author: Phuc Van Pham
Publisher: BoD – Books on Demand
ISBN: 9535136151
Category : Science
Languages : en
Pages : 302
Get Book Here
Book Description
Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.
Author: Robert Gunzburg
Publisher: Springer Science & Business Media
ISBN: 9783540202950
Category : Medical
Languages : en
Pages : 182
Get Book Here
Book Description
Joint replacement is a logical step in the treatment of severe joint pathologies with irreversible lesions resisting conservative therapy. At the spinal level, arthrodesis became, very early, the gold standard of treatment for severe intervertebral disc pathologies. The next logical step was to envision functional replacement, and this step was taken as early as 1956, when the first intervertebral implant was described. However, it took many more years and a great variety of proposed implant designs before clinical applications could be attempted.
Author: Andy Shores
Publisher: John Wiley & Sons
ISBN: 1118711521
Category : Medical
Languages : en
Pages : 887
Get Book Here
Book Description
Current Techniques in Canine and Feline Neurosurgery offers state-of-the-art, detailed guidance on performing neurosurgical techniques in dogs and cats, from indications and surgical anatomy to procedures and post-operative care. Presents an up-to-date, detailed reference on veterinary neurosurgery techniques, covering skills ranging from basic to advanced Provides guidance on why, when, and how to perform neurosurgical procedures Includes information on diagnostic evaluation, surgical planning, and instrumentation as well as step-by-step descriptions of specific procedures Copublished with the American College of Veterinary Surgeons Foundation and American College of Veterinary Internal Medicine Offers video clips on a companion website
Author: Sibylle Grad
Publisher: Morgan & Claypool Publishers
ISBN: 9781608454655
Category : Technology & Engineering
Languages : en
Pages : 104
Get Book Here
Book Description
Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration
Author: Joseph E. Brown
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 240
Get Book Here
Book Description
Author: Martin J. Stoddart
Publisher: Academic Press
ISBN: 0128115386
Category : Medical
Languages : en
Pages : 272
Get Book Here
Book Description
Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. - Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes - Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues - Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering - Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering - Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair
Author: Michael Fehlings
Publisher: Academic Press
ISBN: 0128198362
Category : Medical
Languages : en
Pages : 646
Get Book Here
Book Description
Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples
