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Author: Thomas T. MacDonald
Publisher: S Karger Ag
ISBN: 9783805567220
Category : Medical
Languages : en
Pages : 241
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Book Description
There are more T cells in the gastrointestinal tract and lung than in the rest of the body combined. The aim of this book is to cover all the important aspects of the biology of these cells in animals and in man. Basic observations are described as well as disease states where aberrant activation of mucosal T cells causes tissue damage. The continuing discovery of features of mucosal T cells which make them different from T cells in the periphery is a consistent theme throughout the text. Topics discussed include new developments in understanding why the characteristic response of mucosal T cells to soluble antigens is tolerance, the role of the gut epithelium in intestinal immunity, the molecular basis by which T cells home to the gut mucosa, the functions of gammadelta T cells, the discovery of a new lymphoid organ - the cryptopatch - in the mouse gut, and the remarkable oligoclonality of the alphabeta and gammadelta T cells in the gut epithelium. In more disease-related sections, the way in which T cells play a role in asthma and protection from parasite infection, and how they cause inflammatory bowel disease in man and animals are described. Providing an excellent survey of the field, this book is a valuable resource for both basic scientists and clinicians interested in intestinal immunology and gastrointestinal disease.
Author: Thomas T. MacDonald
Publisher: S Karger Ag
ISBN: 9783805567220
Category : Medical
Languages : en
Pages : 241
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Book Description
There are more T cells in the gastrointestinal tract and lung than in the rest of the body combined. The aim of this book is to cover all the important aspects of the biology of these cells in animals and in man. Basic observations are described as well as disease states where aberrant activation of mucosal T cells causes tissue damage. The continuing discovery of features of mucosal T cells which make them different from T cells in the periphery is a consistent theme throughout the text. Topics discussed include new developments in understanding why the characteristic response of mucosal T cells to soluble antigens is tolerance, the role of the gut epithelium in intestinal immunity, the molecular basis by which T cells home to the gut mucosa, the functions of gammadelta T cells, the discovery of a new lymphoid organ - the cryptopatch - in the mouse gut, and the remarkable oligoclonality of the alphabeta and gammadelta T cells in the gut epithelium. In more disease-related sections, the way in which T cells play a role in asthma and protection from parasite infection, and how they cause inflammatory bowel disease in man and animals are described. Providing an excellent survey of the field, this book is a valuable resource for both basic scientists and clinicians interested in intestinal immunology and gastrointestinal disease.
Author: Donald Gullberg
Publisher: Springer
ISBN: 9401791538
Category : Medical
Languages : en
Pages : 188
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Book Description
The integrin family is composed of 24 members and approximately ten years ago (2003) we published a book devoted to the nine I domain integrin subunits. In this second edition, I am pleased that most of the original authors have been able to contribute to the updated version. I domain containing integrins include collagen receptors and leukocyte receptors. In 2003 the knockout mouse phenotypes for all of the I domain integrins had not yet been published; they are now, and are summarized and discussed in this edition. Interestingly, a recent 10 integrin mutation in dogs has indicated that collagen-binding integrins in the musculoskeletal system might have much more severe phenotypes in larger animals/humans compared to the mild integrin phenotypes observed in collagen-binding integrin deficient mice. This finding is further discussed in the book. In the cancer field, the microenvironment is taking center stage, and here collagen receptors on fibroblasts are predicted to play important roles in paracrine signaling, in regulating tissue stiffness and matrix remodeling. New technologies, new mouse models in combination with analyses of I integrins in larger animals/humans are thus predicted to increase our knowledge about this group of receptors. With this in mind we look forward to another 10 years of research with I domain integrins.
Author: Erkki Ruoslahti
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 680
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Book Description
This publication presents a collection of essays that reflect current research and technical advances in extracellular matrix field, which has undergone remarkable expansion since publication of Volume 82 of 'Methods in Enzymology' in 1982.
Author: Fernando Gomollón
Publisher: Frontiers Media SA
ISBN: 2889669742
Category : Medical
Languages : en
Pages : 119
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Book Description
Author: Katsunori Tanaka
Publisher: John Wiley & Sons
ISBN: 3527344322
Category : Science
Languages : en
Pages : 560
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Book Description
Provides timely, comprehensive coverage of in vivo chemical reactions within live animals This handbook summarizes the interdisciplinary expertise of both chemists and biologists performing in vivo chemical reactions within live animals. By comparing and contrasting currently available chemical and biological techniques, it serves not just as a collection of the pioneering work done in animal-based studies, but also as a technical guide to help readers decide which tools are suitable and best for their experimental needs. The Handbook of In Vivo Chemistry in Mice: From Lab to Living System introduces readers to general information about live animal experiments and detection methods commonly used for these animal models. It focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release. Topics include: currently available mouse models; biocompatible fluorophores; radionuclides for radiodiagnosis/radiotherapy; live animal imaging techniques such as positron emission tomography (PET) imaging; magnetic resonance imaging (MRI); ultrasound imaging; hybrid imaging; biocompatible chemical reactions; ligand-directed nucleophilic substitution chemistry; biorthogonal prodrug release strategies; and various selective targeting strategies for live animals. -Completely covers current techniques of in vivo chemistry performed in live animals -Describes general information about commonly used live animal experiments and detection methods -Focuses on chemistry-based techniques to develop selective in vivo targeting methodologies, as well as strategies for in vivo chemistry and drug release -Places emphasis on material properties required for the development of appropriate compounds to be used for imaging and therapeutic purposes in preclinical applications Handbook of In Vivo Chemistry in Mice: From Lab to Living System will be of great interest to pharmaceutical chemists, life scientists, and organic chemists. It will also appeal to those working in the pharmaceutical and biotechnology industries.
Author: Stewart Martin
Publisher: Humana Press
ISBN: 9781588299079
Category : Medical
Languages : en
Pages : 358
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Book Description
As experimentation and clinical trials with first generation anti-angiogenic agents have yielded results and our understanding of the biology and physiology of blood and lymphatic vessels has increased, a new angiogenesis volume swiftly became a necessity. Angiogenesis Protocols, Second Edition remains true to its original vision of providing a single source for angiogenesis researchers, irrespective of levels of resource and expertise, by collecting a range of methods for cell isolation and assessing angiogenesis in vivo or in vitro. This information, however, is expanded to include chapters on circulating endothelial progenitor cells, angiogenic signalling pathways, imaging of angiogenesis, and measurement of tissue blood flow. Written in the Methods in Molecular BiologyTM series format, the chapters provide step-by-step laboratory protocols, lists of necessary materials and reagents, and a Notes section, which details tips on troubleshooting and avoiding known pitfalls. Extensive and cutting-edge, Angiogenesis Protocols, Second Edition is not only a practical handbook for key techniques, but also an informative and enjoyable read for all those interested, no matter how directly, in angiogenesis.
Author: Martine Extermann
Publisher: Springer
ISBN: 9783319574141
Category : Medical
Languages : en
Pages : 1150
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Book Description
This book is intended as a comprehensive resource for clinicians and researchers seeking in-depth information on geriatric oncology. The coverage encompasses epidemiology, the biology and (patho)physiology of aging and cancer, geriatric assessment and management, hematologic malignancies, solid tumors, issues in patient care, and research methods. Since cancer is a disease of aging and people are living longer, most cancer patients are now aged 70 and older. Yet the more we age, the more diverse we become in terms of our health, biologic fitness, and cancer behavior. Typically, however, general oncology clinical trials address only a selected healthier and younger population of patients. Geriatric oncology is the area of oncology that addresses these issues but while a wealth of knowledge has been accumulated, information is often difficult to retrieve or insufficiently detailed. The SpringerReference program, in which this book is published, offers an ideal format for overcoming these limitations since it combines thorough coverage with access to living editions constantly updated chapter by chapter via a dynamic peer-review process, ensuring that information remains current and pertinent.
Author: Razelle Kurzrock
Publisher: Springer Science & Business Media
ISBN: 1603274243
Category : Medical
Languages : en
Pages : 447
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Book Description
Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, this volume provides a state-of-the-art overview. It will be valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field.
Author: Stuart K. Calderwood
Publisher: Springer Science & Business Media
ISBN: 1402064012
Category : Medical
Languages : en
Pages : 399
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Book Description
Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Author: Massimo Fantini
Publisher: Frontiers Media SA
ISBN: 2889766691
Category : Medical
Languages : en
Pages : 285
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Book Description
