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Author: Michael Bliss
Publisher: University of Toronto Press
ISBN: 1487529139
Category : Diabetes
Languages : en
Pages : 351
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Book Description
This special centenary edition of The Discovery of Insulin celebrates a path-breaking medical discovery that has changed lives around the world.
Author: Michael Bliss
Publisher: University of Toronto Press
ISBN: 1487529139
Category : Diabetes
Languages : en
Pages : 351
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Book Description
This special centenary edition of The Discovery of Insulin celebrates a path-breaking medical discovery that has changed lives around the world.
Author: Jens Brange
Publisher: Springer Science & Business Media
ISBN: 3662025264
Category : Medical
Languages : en
Pages : 108
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Book Description
Galenical pharmacy or galenics is the science dealing with the pro duction of drug substances from raw materials, the purity of such substances, their formulation into pharmaceutical preparations with the desired effects and safety in use, and the quality control, stability and storage of the preparations. The field has taken its name from the Greek physician Galen (131-201 A.D.), who had a profound influence on medicine for many centuries because he collected and systematized the medicinal knowledge of his time. The discovery of insulin is attributed to Banting and Best who, in 1921, prepared an extract of the pancreas of the fetal calf and showed that the extract was capable of reducing the blood sugar level of a diabetic dog. This outstanding discovery gave rise to the rapid develop ment of the manufacture of insulin of bovine and porcine origin. By 1925, two Danish manufacturers of insulin preparations were established; both have since been in the forefront ofthe development of insulin preparations, the latest achievement being the marketing of human insulin by Novo in 1982. The development of highly purified human insulin produced semisynthetically from porcine insulin or by DNA recombinant methods are significant contributions to safe and efficient insulin therapy. Insulin is a protein which is destroyed in the gastrointestinal tract.
Author: D.R. Owens
Publisher: Springer Science & Business Media
ISBN: 9400941617
Category : Medical
Languages : en
Pages : 307
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Book Description
Since insulin became available for the treatment of diabetes in 1922 a number of major advances have been made, which include the modification of insulin to vary its timing of action, its purification, and latterly, the production of human insulin. Human insulin in quantities sufficiently large for therapy has been made available by two techniques developed in parallel during the late 1970s. These involve either (i) formulation in E. coli bacteria suitably encoded by DNA recombinant methods of the A- and B-chains of human insulin followed by a chain combination reaction ('biosynthetic' human insulin) or (ii) enzymatic conversion (transpeptidation) of porcine insulin brought to react with a threonine ester by porcine trypsin in a mixture of water and organic solvents, yielding human insulin ('semi-synthetic' human insulin). This book includes the first clinical-pharmacological studies of each of the highly purified 'semi-synthetic' human insulin preparations: Actrapid ® HM; Monotard® HM; Protaphane® HM; Actraphane® HM; and Ultratard® HM (Novo Industri A/S, Copenhagen). The preliminary studies established their safety and efficacy relative to their porcine and bovine counterparts emphasising the relevance of species and formulation on the pharmacokinetics and biological responses to insulin. Additional investigations with human insulin demonstrated the influence of insulin concentration, site of administration, the addition of aprotinin to insulin and the mixing of 'short-' and 'intermediate-acting' formulations on insulin 'bioavailability'. Examination of the 'within' and 'between' subject day-to-day variation in absorption and the effect of subcutaneous insulin also demonstrates the dominating influence of insulin responsiveness.
Author: Alison Li
Publisher: McGill-Queen's Press - MQUP
ISBN: 0773571450
Category : Social Science
Languages : en
Pages : 270
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Book Description
In the early years of the twentieth century medical research in Canada was the job of a select few. By mid-century it had grown into a systematic, large-scale venture that involved teams of professional scientists and dozens of laboratories in universities, government, and industry. J.B. Collip - skilled both as a bench scientist and an entrepreneur - played a leading role in this transformation. In J.B. Collip and the Development of Medical Research in Canada Alison Li details how Collip leapt into prominence in 1921-22 as part of the team at the University of Toronto that isolated insulin. When the Nobel Prize was awarded to Frederick Banting and J.J.R. Macleod in 1923, Banting announced he was sharing his award with Charles Best; Macleod in turn announced he was sharing his award with Collip. Collip was known for his remarkable skills in making hormone extracts, many of which proved to have therapeutic, and therefore commercial, value. At McGill University in the 1930s he headed a thriving research group that carried out investigations of the pituitary and sex hormones, including development of one of the first orally active estrogen products. Collip's story sheds light on early negotiations between academic science and the pharmaceutical industry and on the complexities of sustaining a research laboratory before the rise of government funding. As the head of the National Research Council's medical research division during its formative years, Collip helped shape the foundations of organized support for medical research in Canada.
Author: Werner Creutzfeldt
Publisher:
ISBN:
Category : Diabetes
Languages : en
Pages : 398
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Book Description
Author: Cecilia C. Low Wang
Publisher: American Diabetes Association
ISBN: 1580406777
Category : Medical
Languages : en
Pages : 253
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Book Description
Type 1 diabetes, formerly known as juvenile diabetes, is a complex disorder that requires a great deal of patient-guided self-care. In recent years, advances in diabetes treatment have dramatically shifted potential outcomes in the favor of the patient with diabetes. The challenge for health care professionals is to realize this potential through an individualized, flexible, and responsive treatment plan for patients with type 1 diabetes. Now in its seventh edition, Medical Management of Type 1 Diabetes offers health care providers the newest information and guidelines for the treatment of type 1 diabetes. Built on the foundation of multiple daily insulin injections and insulin pump therapy, this book guides health care providers in helping their patients continually strive for optimal blood glucose control. This new edition focuses on the latest molecular advances, new treatment methods, recent clinical trials, and the American Diabetes Association's Standards of Care. Key topics also include new insulins and administration protocols, advanced carbohydrate counting, and emphasis on continuing patient education. Individual sections address all of the topics in managing type 1 diabetes, including diagnosis and classification/pathogenesis, diabetes standards and education, tools of therapy, special situations, psychosocial factors affecting adherence, quality of life, and well-being and complications. Medical Management of Type 1 Diabetes is an essential addition to any clinician's library for the treatment and understanding of type 1 diabetes.
Author: Kinga Howorka
Publisher: Springer Science & Business Media
ISBN: 3642799973
Category : Medical
Languages : en
Pages : 239
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Book Description
Functional Insulin Treatment (FIT) is the most effective method of treatment for type 1(insulin-dependent) diabetes available today. Whether with an insulin pump or with multiple daily injections, the diabetic patient trained in FIT is able to dose his insulin on the basis of actual fuction so that he achieves near-normoglycemia and the freedom to eat when, what and how much he wants. The goal of FIT is to adapt the therapy to the lifestyle of the patient. This book creates a common basis for communication among therapists (physicians, nurses, dietitians, diabetes educators) and patients involved in FIT. It clearly defines the principles of the treatment and describes the contents, media and techniques of a practical program for training patients to carry it out.
Author: Neil Schneiderman
Publisher: Springer Science & Business Media
ISBN: 1489909060
Category : Medical
Languages : en
Pages : 713
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Book Description
Cardiovascular disease continues to be the number ioral medicine" was developed and shaped into the one source of morbidity and mortality in our coun following definition: try. Despite a 35% reduction since 1964, these Behavioral medicine is the interdisciplinary field con diseases, particularly coronary heart disease cerned with the development and integration of behav (CHD), claim nearly 1,000,000 lives each year in ioral and biomedical science knowledge and techniques the United States (Havlik & Feinleib, 1979). relevant to the understanding of health and illness and The Framingham study, among others, has iden the application of this knowledge and these techniques to prevention, diagnosis, treatment and rehabilitation. tified three major risk factors implicated in the de (Schwartz & Weiss, 1978) velopment of CHD: smoking, elevated serum cho lesterol, and high blood pressure (Castelli et at., This concept of "biobehavioral" collaboration 1986). Given that these factors account for less challenged scientists and clinicians of many disci than 50% of the variance associated with CHD plines to consider how they might more effectively (Jenkins, 1976), it has become obvious that addi develop diagnostic, treatment, and prevention tional risk factors must be identified if further pro strategies by merging their perspectives to address gress is to be made in disease prevention and simultaneously, among others, behavioral, psy control.
Author: C. E. Mogensen
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 311085032X
Category : Medical
Languages : en
Pages : 388
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Book Description
No detailed description available for "Pharmacology of Diabetes".
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1000
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Book Description
