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Author: William M. Reichert
Publisher: CRC Press
ISBN: 9781420009309
Category : Science
Languages : en
Pages : 296
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Book Description
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. This seminal work provides researchers with an up-to-date account of the progress in the field that they can build upon to bring us closer to realizing the full value of neural implants in combating otherwise intractable human health problems.
Author: William M. Reichert
Publisher: CRC Press
ISBN: 9781420009309
Category : Science
Languages : en
Pages : 296
Get Book
Book Description
Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwelling Neural Implants: Strategies for Contending with the In Vivo Environment examines many of these challenges, paying particular attention to how the healing of tissues surrounding an implant can impact the intended use of a device. The contributions are divided into four sections · Part one examines wound healing from the initial insertion trauma through the inflammatory and repair process, explaining how the action of healing varies throughout different areas of the body. · Part two considers various performance issues specific to particular implant components, including those that arise from the chemical, mechanical, thermal, and electrical impact on surrounding tissues. It discusses challenges that result from chronic tissue stimulation and heat effects that occur with on-chip and telemetric processing. · Part three presents both in vitro and in vivo approaches to assessing wound healing response to materials. It includes the contribution of the developer of a chronic hollow fiber membrane implant who explains how an in vivo model is used to assess molecular transport in brain tissue surrounding the implant. · The final section evaluates molecular and materials strategies for intervening in CNS wound repair and enhancing the electrical communication between the electrode surface and the surrounding tissue. It also presents novel approaches to nerve regeneration and repair. This seminal work provides researchers with an up-to-date account of the progress in the field that they can build upon to bring us closer to realizing the full value of neural implants in combating otherwise intractable human health problems.
Author: Michael E. Selzer
Publisher: Cambridge University Press
ISBN: 1107011671
Category : Nervous system
Languages : en
Pages : 693
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Book Description
In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.
Author: Christopher Spicer
Publisher: Royal Society of Chemistry
ISBN: 1788017536
Category : Science
Languages : en
Pages : 323
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Book Description
This book overviews the underlying chemistry behind the most common and cutting-edge inorganic materials in current use, or approaching use, in vivo.
Author: National Research Council
Publisher: National Academies Press
ISBN: 030916785X
Category : Science
Languages : en
Pages : 223
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Book Description
Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.
Author: Kanishka Rajput
Publisher: Springer Nature
ISBN: 3030552624
Category : Medical
Languages : en
Pages : 429
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Book Description
This book provides a comprehensive review of the challenges, risk stratification, approaches and techniques needed to improve pain control in ambulatory surgery centers (ASCs). It addresses not only the management of acute perioperative pain but also describes modalities that could potentially reduce the risk of evolution of acute pain into chronic pain, in addition to weaning protocols and follow ups with primary surgical specialties and pain physicians as needed. Organized into five sections, the book begins with the foundations of managing ASCs, with specific attention paid to the current opioid epidemic and U.S. policies relating to prescribing opioids to patients. Section two and three then explore facets of multimodal analgesia and non-operating room locations, including the use of ultrasounds, sedation in specific procedures, regional anesthesia, ketamine infusions, and the management of perioperative nausea and intractable pain in outpatient surgery. Section four examines the unique challenges physicians face with certain patient demographics, such as the pediatric population, those suffering from sleep apnea, and those with a history of substance abuse. The book closes with information on discharge considerations, ambulatory surgery protocols, recovery room protocols, and mandatory pain management services. An invaluable reference for all health personnel and allied specialties, Pain Control in Ambulatory Surgery Centers (ASCs) meets the unmet need for a resource that covers optimum pain control in patients undergoing outpatient surgery as well as the urgent ASCs challenges that are presented on an immense scale with national and international impact.
Author: Miguel A. L. Nicolelis
Publisher: CRC Press
ISBN: 9781420006414
Category : Science
Languages : en
Pages : 296
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Book Description
In the last ten years neural ensemble recording grew into a well-respected and highly data-lucrative science. New experimental paradigms, including the fabrication of high-density microelectrodes, new surgical implantation techniques, multi-channel signal processing, and the establishment of direct real-time brain-machine interfaces, hold promise not just for neurophysiology research, but also for new-generation prosthetic devices aimed at restoring mobility and communication skills in severely disabled patients. Extensively updated and expanded, Methods for Neural Ensemble Recording, Second Edition distills the current state-of-the-science and provides the nuts and bolts foundation from which to advance the field for the next ten years. With contributions from pioneering researchers, this second edition begins with an overview of microwire array design for chronic neural recordings. Demonstrating the diversity now enjoyed in the field, the book reviews new surgical techniques for chronic implantation of microwire arrays in not just rodents, but primates as well. It explores microelectrode microstimulation of brain tissue, discusses multielectrode recordings in the somatosensory system and during learning, and analyzes neural ensemble recordings from the central gustatory-reward pathways in awake and behaving animals. An exploration of new strategies for neural ensemble data analysis for Brain-Machine Interface (BMI) applications foreshadows an investigation into employing BMI to restore neurological function. Using multielectrode field potential recordings, contributions define global brain states and propose conceptual and technical approaches to human neural ensemble recordings in the future.
Author: Basil F. Matta
Publisher: Cambridge University Press
ISBN: 1139499858
Category : Medical
Languages : en
Pages :
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Book Description
Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.
Author: William F. Agnew
Publisher:
ISBN:
Category : Electric Stimulation
Languages : en
Pages : 344
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Book Description
Author: Bruna Corradetti
Publisher: Springer
ISBN: 3319454331
Category : Technology & Engineering
Languages : en
Pages : 241
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Book Description
This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.
Author: Greg McLatchie
Publisher: OUP Oxford
ISBN: 0191015911
Category : Medical
Languages : en
Pages : 525
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Book Description
This bestselling Oxford Handbook has been thoroughly revised for the new edition to include brand new chapters on Paediatric Orthopaedics and Common Surgical Procedures, as well as new presentations, illustrations, and new anatomy and emergency indexes to aid quick reference. It is an invaluable tool for junior surgical trainees, medical students, nursing, paramedical, and rehabilitation staff. The handbook covers the assessment and preparation of the patient, anaesthesia and critical care, inflammation, wound healing and infection, and the key components of general surgical practice, as well as chapters on other surgical specialties, including plastic, paediatric, and orthopaedic surgery. There are step-by-step descriptions of common operative surgical techniques, practical hints and procedures, and information on signs, symptoms and rarities. Emergency presentations are clearly identified for rapid reference and investigations and management plans are set out in a clear and easy-to-follow way. Surgically relevant anatomy and physiology has been expanded for each area, quick reference symbols ensure the reader is guided to key facts, and there is an increased focus on evidence-based practice with key references throughout. A cut above the rest, this is the essential guide to clinical surgery and the surgical specialities.
