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Author: Imperial Cancer Research Fund (Great Britain)
Publisher:
ISBN:
Category : Tumors
Languages : en
Pages : 260
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Book Description
Author: Imperial Cancer Research Fund (Great Britain)
Publisher:
ISBN:
Category : Tumors
Languages : en
Pages : 260
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Book Description
Author: Charles Swanton
Publisher: Perspectives Cshl
ISBN: 9781621821434
Category : Medical
Languages : en
Pages : 350
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Book Description
Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.
Author: Kerry S. Courneya
Publisher: Springer Science & Business Media
ISBN: 3642042317
Category : Medical
Languages : en
Pages : 389
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Book Description
This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors are discussed, and behavior change strategies for increasing physical activity in cancer survivors are appraised. The final part of the book is devoted to special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.
Author: Imperial Cancer Research Fund (Great Britain)
Publisher:
ISBN:
Category :
Languages : en
Pages : 518
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Book Description
Author: Maureen A. Harrison
Publisher: Cambridge University Press
ISBN: 9780521574969
Category : Science
Languages : en
Pages : 178
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Book Description
Concise introduction to a major technique of cell biology laboratories for those new to the field.
Author: Joan Austoker
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 416
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Book Description
This book examines the spectacular progress that has been made in cancer research during the last 80 years, describing the way discoveries have been made and asking questions about accountability, decision making, and the contribution of past achievement to policymaking. The focus is on the experience of the Imperial Cancer Research Fund, one of the leading international research centers and one of Britain's major medical charities. The author takes a broad perspective and provides a comparative framework by discussing the changing relationship between the ICRF and the medical profession, government, and other charities, notably the Cancer Research Campaign. The resulting analysis of intellectual developments and scientific polices involves a unique overview of malignant disease management, therapeutic and preventative strategies, and the evolution of cancer services in Britain.
Author: Kenneth Charles Calman
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 180
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Book Description
Author: Imperial Cancer Research Fund (Great Britain)
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 324
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Book Description
Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1628
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Book Description
First multi-year cumulation covers six years: 1965-70.
Author: Carlo C. Maley
Publisher: Springer
ISBN: 1493964607
Category : Medical
Languages : en
Pages : 266
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Book Description
This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.
