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Author: Md. Naimat Ali
Publisher: Elsevier
ISBN: 0443185115
Category : Medical
Languages : en
Pages : 308
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Book Description
Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides broad coverage to diverse aspects of immunotoxicogenomics. The book covers the major mechanisms and effects of toxic substances on the immune system and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, emerging and future trends in immunotoxicogenomics.The book starts off with a discussion of the systemic approach to the study of toxicants. It also looks at the current genomic tools used to assess immunotoxicity and the systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, the use of gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data. Future trends round off the discussion in the book. Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides a collaborative multidisciplinary approach for researchers in the fields of toxicology, genetics, and immunology and others engaged in the study on the effects of toxic substances on immune responses. - Offers background and progress information for clinical applications and potential immunotoxicogenomics prospects - Covers the major mechanisms currently known by which toxic substances affect the immune system and gene expression - Provides a multidisciplinary approach to immunotoxicology, with updated content on fundamentals, the latest breakthroughs, clinical applications, and future perspectives
Author: Md. Naimat Ali
Publisher: Elsevier
ISBN: 0443185115
Category : Medical
Languages : en
Pages : 308
Get Book Here
Book Description
Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides broad coverage to diverse aspects of immunotoxicogenomics. The book covers the major mechanisms and effects of toxic substances on the immune system and on the regulation of gene expression. This includes the aims, opportunities, clinical applications, recent developments, emerging and future trends in immunotoxicogenomics.The book starts off with a discussion of the systemic approach to the study of toxicants. It also looks at the current genomic tools used to assess immunotoxicity and the systems biology methods used in immuno-toxicogenomics. Other topics include genomic expression profiling, the use of gene expression as a tool to understand and predict immunotoxicity, immunotox-icogenomics as a screening tool, and the assessment and analysis of Immunotoxicogenomics data. Future trends round off the discussion in the book. Immunotoxicogenomics: A Multidisciplinary Approach in Systems Toxicology provides a collaborative multidisciplinary approach for researchers in the fields of toxicology, genetics, and immunology and others engaged in the study on the effects of toxic substances on immune responses. - Offers background and progress information for clinical applications and potential immunotoxicogenomics prospects - Covers the major mechanisms currently known by which toxic substances affect the immune system and gene expression - Provides a multidisciplinary approach to immunotoxicology, with updated content on fundamentals, the latest breakthroughs, clinical applications, and future perspectives
Author: Saura C. Sahu
Publisher: John Wiley & Sons
ISBN: 0470699647
Category : Science
Languages : en
Pages : 422
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Book Description
Toxicogenomics is the integration of genomics to toxicology. This technology is a powerful tool for collecting information from a large number of biological samples simultaneously and thus it is very useful for large-scale screening of potential toxicants. Toxicogenomics: A Powerful Tool For Toxicity Assessment provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology. Topics covered include: mechanistic toxicogenomics analysis and interpretation of toxicogenomic data principles of data mining in toxicogenomics design issues in toxicogenomics studies sources of variability in toxicogenomic assays Escherichia coli stress response as a tool for detection of toxicity toxicogenomics as a tool to assess immunotoxicity toxicogenomics and ecogenomics for studying endocrine disruption and basic biology use of toxicogenomics as an early predictive tool for hepatotoxicity nutrigenomics: the application of genomic signatures in nutrition-related research application of toxicogenomics in drug discovery potential uses of toxicogenomic biomarkers in occupational health and risk assessment usefulness of toxicogenomics in the regulatory environment perspectives on toxicogenomics at the US Environmental Protection Agency Toxicogenomics: A Powerful Tool For Toxicity Assessment is an essential resource for research scientists currently engaged in toxicogenomics, and will also be of interest to researchers working in toxicology, genetics, medicine, pharmacology, and food sciences, and to regulators and risk assessors of drug, food, environmental and agricultural products.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309112982
Category : Science
Languages : en
Pages : 300
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Book Description
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
ISBN: 1439830096
Category : Medical
Languages : en
Pages : 312
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Book Description
In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an
Author: Jos Kleinjans
Publisher: Academic Press
ISBN: 0123978718
Category : Medical
Languages : en
Pages : 367
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Book Description
Toxicogenomics-Based Cellular Models is a unique and valuable reference for all academic and professional researchers employing toxicogenomic methods with respect to animal testing for chemical safety. This resource offers cutting-edge information on the application of toxicogenomics to developing alternatives to current animal toxicity tests. By illustrating the development of toxicogenomics-based cellular models for critical endpoints of toxicity and providing real-world examples for validation and data analysis, this book provides an assessment of the current state of the field, as well as opportunities and challenges for the future. Written by renowned international toxicological experts, this book explores 'omics technology for developing new assays for toxicity testing and safety assessment and provides the reader with a focused examination of alternative means to animal testing. - Describes the state-of-the-art in developing toxicogenomics-based cellular models for chemical-induced carcinogenicity, immunotoxicity, developmental toxicity, neurotoxicity and reproduction toxicity - Illustrates how to validate toxicogenomics-based alternative test models and provides an outlook to societal and economic implementation of these novel assays - Includes an overview of current testing methods and risk assessment frameworks - Provides a real-world assessment by articulating the current development and challenges in toxicogenomics while suggesting ways to move this field forward
Author: Mikko Nikinmaa
Publisher: Elsevier
ISBN: 0124115810
Category : Science
Languages : en
Pages : 253
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Book Description
An Introduction to Aquatic Toxicology is an introductory reference for all aspects of toxicology pertaining to aquatic environments. As water sources diminish, the need to understand the effects that contaminants may have on aquatic organisms and ecosystems increases in importance. This book will provide you with a solid understanding of aquatic toxicology, its past, its cutting-edge present and its likely future. An Introduction to Aquatic Toxicology will introduce you to the global issue of aquatic contamination, detailing the major sources of contamination, from where they originate, and their effects on aquatic organisms and their environment. State-of-the-art toxicological topics covered include nanotoxicology, toxicogenomics, bioinformatics, transcriptomics, metabolomics, as well as water management and the toxicological effects of major environmental issues such as algal blooms, climate change and ocean acidification. This book is intended for anyone who wants to know more about the impact of toxicants on aquatic organisms and ecosystems, or to keep up to date with recent and future developments in the field. - Provides with the latest perspectives on the impacts of toxicants on aquatic environments, such as nanotoxicology, toxicogenomics, ocean acidification and eutrophication - Offers a complete overview, beginning with the origins of aquatic toxicology and concluding with potential future challenges - Includes guidance on testing methods and a glossary of aquatic toxicology terms
Author: Darrell R. Boverhof
Publisher: John Wiley & Sons
ISBN: 1118008987
Category : Science
Languages : en
Pages : 470
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Book Description
This book provides a timely overview of toxicogenomics, with special emphasis on the practical applications of this technology to the risk assessment process. Introductory sections are followed by a series of chapters highlighting practical and systematic applications of toxicogenomics in informing the risk assessment process – including the areas of mutagenicity, carcinogenicity, endocrine toxicity, organ-specific toxicity, population monitoring, and ecotoxicology. The book concludes with approaches for the integration of this technology in safety evaluation studies, and an outlook on how toxicogenomics and complementary technologies can reframe the current risk assessment paradigm.
Author: Katalin Gruiz
Publisher: CRC Press
ISBN: 1315778777
Category : Science
Languages : en
Pages : 579
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Book Description
Chemical substances, physical agents and built structures exhibit various types of hazard due to their inherent toxic, mutagenic, carcinogenic, reprotoxic and sensitizing character or damaging to the immune and hormone system. The first steps in managing an environment contaminated by chemical substances are characterization of hazards and quantifi
Author: Rakesh Kumar Tekade
Publisher: Elsevier
ISBN: 0443158436
Category : Medical
Languages : en
Pages : 854
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Book Description
Toxicodynamics in Drug Research, Volume 2: Public Health and Toxicology Issues examines the implications of public health issues and the impact of pharmaceuticals, chemical and food toxicants, dietary phytochemicals, and medical treatments on human health. Volume 2: Public Health and Toxicology Issues in Drug Research: Toxicity and Toxicodynamics covers topics on pharmacokinetics and toxicokinetics such as population pharmacokinetics/toxicokinetics, the design of toxicokinetic studies, and the use of toxicokinetic data in preclinical safety assessments. The book investigates the health effect caused by the bioaccumulation of pharmaceutical and personal care products and the impact of drug-induced toxicity on different systems of the body. It discusses the mechanistic pathways of food toxicants and illustrates the molecular mechanisms of the chemopreventive role of dietary phytochemicals. It also delves into the toxic effects of medical treatments and materials. Ethical, legal, societal, and professional issues in toxicology round off the coverage providing a valuable resource to interested in learning more about the health impact and public health issues related to the toxicity of pharmaceuticals, dietary supplements, personal care products, and medical treatments. - Discusses the impact of pharmaceuticals, food, and chemical toxicants on human health - Examines the toxic effects of medical treatments, clinical administrations, and materials - Explores public health issues around drug safety and toxicology
Author: Loriano Ballarin
Publisher: Academic Press
ISBN: 0128032537
Category : Medical
Languages : en
Pages : 326
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Book Description
Lessons in Immunity: From Single-cell Organisms to Mammals stems from the activity of the Italian Association of Developmental and Comparative Immunobiology (IADCI), represented by the editors. This book is presented as a series of short overviews that report on the current state of various relevant fields of immunobiology from an evolutionary perspective. The overviews are written by authors directly involved in the research, and most are members of the IADCI or have otherwise been involved in the related research for their respective overview. This publication offers scientists and teachers an easy and updated reference tool. - Provides simple and updated reviews on the immunobiology of a wide spectrum of organisms, considered in an evolutionary context - Focuses on both cells and humoral components of a variety of non-classical model organisms - Offers in a single volume many contributions which can help with understanding the evolution of immune responses and the main adaptations in animal phyla - Presents a valuable holistic cross-sectional approach for teaching immunology and its applications
