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Author: Kelly M. Fulton
Publisher: Humana Press
ISBN: 9781627035903
Category : Medical
Languages : en
Pages : 370
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Book Description
Providing current diverse approaches and techniques used to study the immunoproteome, Immunoproteomics: Methods and Protocols collects chapters from key researchers that deliver information to be used in diagnostics, disease progression, and vaccine correlates of protection analysis, to name but a few. This detailed volume includes techniques used for the study of the antibody targets of bacterial pathogens, viruses, and cancer, mass spectrometry-based approaches to characterize T-cell epitopes, chapters on detection and relative quantification of cytokines in serum, as well as in silico prediction of epitopes using sequence-based or modeling approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Immunoproteomics: Methods and Protocols aids researchers in transferring these techniques to their own laboratories in addition to providing a reference to guide researchers toward appropriate techniques.
Author: Kelly M. Fulton
Publisher: Humana
ISBN: 9781493995967
Category : Medical
Languages : en
Pages : 380
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Book Description
This second edition volume expands on the previous edition with new sections describing the characterization of peptides bound to major histocompatibility complexes (MHC) on the surface of the cell. Chapters also cover topics such as using SERPA for antigen identification; antigen content of electroimmunoprecipitates; whole genome-phage display libraries; antigens in immune complexes; and immunoproteomic biomarkers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Immunoprotemics: Methods and Protocols, Second Edition is a valuable resource that presents novice and expert researchers with techniques that are easily transferrable to laboratories and provides enhanced hands-on insights into this evolving field.
Author: George William Carnell
Publisher: Frontiers Media SA
ISBN: 2832522963
Category : Science
Languages : en
Pages : 179
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Book Description
Author: Roger L. Lundblad
Publisher: CRC Press
ISBN: 1351680536
Category : Medical
Languages : en
Pages : 551
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Book Description
This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers
Author: Daniel S. Sem
Publisher: CRC Press
ISBN: 1420017098
Category : Medical
Languages : en
Pages : 464
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Book Description
Facilitating the innovation, development, and application of new spectroscopic methods in proteomics, Spectral Techniques in Proteomics provides a broad overview of the spectroscopic toolbox that can be used, either with proteome or sub-proteome mixtures or with individual/purified proteins studied in parallel. It gives a modest overview of
Author: Pooja Jain
Publisher: Springer Nature
ISBN: 3030339467
Category : Medical
Languages : en
Pages : 413
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Book Description
This book highlights information derived primarily from clinical samples, with particular reference to theoretical and scientific aspects of the human immune system. This text will focus on topics that range from host-pathogen interactions in infectious disease to host immune response in cancer, allergic diseases, neuroinflammatory diseases, and autoimmune disorders. The reader will also have a well-rounded understanding of the behavior of the immune system with particular emphasis on the role of immunoproteomics in immunotherapy, neuroprotective immunity for neurodegenerative and neuroinfectious disease, leukemia-associated dendritic cell induction of adaptive immunity dysregulation, and the role of immune checkpoint inhibitors in cancer, infection, as well as neuroinflammation. Taken together, the contents of this book are intended for both clinicians and researchers in academia and industry.
Author: Philip Whitfield
Publisher: John Wiley & Sons
ISBN: 0470960647
Category : Science
Languages : en
Pages : 464
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Book Description
The study of proteomics provides researchers with a better understanding of disease and physiological processes in animals. Methods in Animal Proteomics will provide animal scientists and veterinarians currently researching these topics in domestic animals a firm foundation in the basics of proteomics methodology, while also reviewing important advances that will be of interest to established researchers in the field. Chapters will provide practical information on a range of topics including protein identification and separation, bioinformatics, and applications to disease and reproduction research. This text will be written by leading international proteomics experts and essential for researchers in the fields of animal biology and veterinary medicine.
Author: Trine N. Jorgensen
Publisher: Frontiers Media SA
ISBN: 2832503756
Category : Medical
Languages : en
Pages : 192
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Book Description
Author: Anders Sjöstedt
Publisher: Frontiers E-books
ISBN: 2889190013
Category :
Languages : en
Pages : 206
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Book Description
The bacterium today known as Francisella tularensis was first identified 99 years ago and, since then, much research has been devoted to study it and the resulting disease, tularemia. F. tularensis became the focus of an intense research effort during the first half of the 20th century, in particularly in the United States and Soviet Union, since the disease was fairly common. Due to its high infectivity, ease of spread, and severity of the resulting disease, it was one of the agents given the highest priority in the biological weapon programs of the United States and Soviet Union. After termination of these programs in the 1960s, the interest in F. tularensis diminished significantly, but after several decades of little attention, the last decade has led to resurgence in the research on F. tularensis. In 2003, the Science magazine phrased it as follows: “an obscure weapon of the cold war edges into the limelight”. There were multiple reasons for this resurgence, one of which was an increase in the number of tularemia cases in several European countries and, moreover, the intense research effort on potential bioterrorist agents in the US post 9/11. Thereby, the number of annual publications on F. tularensis has tripled in 10 years, and many new research groups, in particular American, have entered the field. This has led to very rapid development of state-of-the-art research tools, and fast progress in the understanding of F. tularensis. A proof of the rapid progress was the publication of a comprehensive volume on Francisella and tularemia in 2007. Although only four years ago, the rapid pace of the research has led to many new discoveries since then and, to this end, we now present a collection of articles from leading scientists on the up-to-date knowledge regarding F. tularensis. The articles cover important areas such as molecular research tools, experimental models, genomics, virulence mechanisms, manipulation and subversion of host responses, host immune responses, and the ecology of F. tularensis.
Author: Muhammad Sarwar Khan
Publisher: CRC Press
ISBN: 1040056709
Category : Medical
Languages : en
Pages : 608
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Book Description
Applied Molecular Biotechnology: The Next Generation of Genetic Engineering explains state-of-the-art advances in the rapidly developing area of molecular biotechnology, the technology of the new millennium. Comprised of chapters authored by leading experts in their respective fields, this authoritative reference text:Highlights the latest omics-ba
Author: Ian Humphery-Smith
Publisher: John Wiley & Sons
ISBN: 0471973157
Category : Science
Languages : en
Pages : 540
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Book Description
Discover important lessons learned about whole organism biology via microbial proteomics This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization. Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed. Key topics covered include: Microbial pathogenesis at the proteome level Whole cell modeling Structural proteomics and computational analysis Biomolecular interactions Physiological proteomics Metabolic reconstruction using proteomics data While presenting the practical utility of proteomics data, the text is also clear on the field's current limitations, pointing to areas where further investigation is needed. Offering a state-of-the-art perspective from internationally recognized experts, this text is ideally suited for researchers and students across the gamut of genomic sciences, including biochemistry, microbiology, molecular biology, genetics, biomedical and pharmaceutical sciences, biotechnology, and veterinary science.
