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Author: Harley Brattain
Publisher: Page Publishing Inc
ISBN: 1642149780
Category : Fiction
Languages : en
Pages : 288
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Book Description
In the world of Deja Pascal aEUR" one of beauty, hope, and endless perfectionaEUR"lurked a darkness. The bloody, cold reality of World War II and its unnumbered shattered lives lay just beyond the trees of their home. Death and loss were unreal to her in the blissful isolation of French hillside until the day a black car carrying a man in a black suit arrived. Watching from a hiding place in the woods, Deja looked on hopelessly as her parents were thrown into the back of a Nazi truck. Pallid and weak, her father, Luc, returned two years later. She never saw her mother again. Compounding the loss of her mother and the effect of the camps on her father, Deja lost her closest friend and confidant in college some years later. Deja's spirit broke from loss, and she became depressed, finally culminating in her taking her own life. Despondent and without hope, Luc, a scientist by trade, decided to use his greatest invention, a device he coined, the Spirit Box, to save her soul from death and bring her back to the world as a timeaEUR"traveling, robotic being suffering for a second chance at a real life, one with meaning and love. Adventuring through ancient Greece, native America, and other fantastical times, she evolved into something more, something greateraEUR"a spirit with purpose. The Deja who left the world a saddened young woman came back strong and potent. She came back as Ikaros.
Author: Harley Brattain
Publisher: Page Publishing Inc
ISBN: 1642149780
Category : Fiction
Languages : en
Pages : 288
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Book Description
In the world of Deja Pascal aEUR" one of beauty, hope, and endless perfectionaEUR"lurked a darkness. The bloody, cold reality of World War II and its unnumbered shattered lives lay just beyond the trees of their home. Death and loss were unreal to her in the blissful isolation of French hillside until the day a black car carrying a man in a black suit arrived. Watching from a hiding place in the woods, Deja looked on hopelessly as her parents were thrown into the back of a Nazi truck. Pallid and weak, her father, Luc, returned two years later. She never saw her mother again. Compounding the loss of her mother and the effect of the camps on her father, Deja lost her closest friend and confidant in college some years later. Deja's spirit broke from loss, and she became depressed, finally culminating in her taking her own life. Despondent and without hope, Luc, a scientist by trade, decided to use his greatest invention, a device he coined, the Spirit Box, to save her soul from death and bring her back to the world as a timeaEUR"traveling, robotic being suffering for a second chance at a real life, one with meaning and love. Adventuring through ancient Greece, native America, and other fantastical times, she evolved into something more, something greateraEUR"a spirit with purpose. The Deja who left the world a saddened young woman came back strong and potent. She came back as Ikaros.
Author: Kevin Andrews
Publisher: Paul Dry Books
ISBN: 158988261X
Category : Biography & Autobiography
Languages : en
Pages : 280
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Book Description
"One of the great and lasting books about Greece."—Patrick Leigh Fermor "An intense and compelling account of an educated, sensitive archaeologist wandering the back country during the civil war. Half a century on, still one of the best books on Greece as it was before 'development.'"—The Rough Guide to the Greek Islands "He also is in love with the country…but he sees the other side of that dazzling medal or moon…If you want some truth about Greece, here it is."—Louis MacNeice, The Observer "One of the best and most honest books about the modern Greeks."—E. R. Dodds "Kevin Andrews experienced the dangers of the countryside during the civil war. The Flight of Ikaros, the book he produced from his travels, remains not only one of the greatest we have about postwar Greece—memorializing a village culture that has almost vanished—but also one of the most moving accounts I have ever read of people caught up in political turmoil…Flightwas first published in 1959 and last reprinted by Penguin in 1984. For too many years, this rare account has languished out of print."—Wall Street Journal In 1947, at the age of twenty-three, Kevin Andrews received a Fulbright Fellowship to study medieval fortresses in the Peloponnese. Andrews spent the long summers of 1948 to 1951 traveling through the region and the winters writing in Athens. This opportunity to travel through little-frequented areas during Greece’s postwar civil war—and before the advent of tourism, industrialization, or easy communications—brought Andrews into immediate contact with village populations, shepherd clans, and the paramilitary vigilantes who kept their own kind of order in the provinces, as well as with the displaced peasants of the Athenian slums. The close experience of all these lives took shape in The Flight of Ikaros, first published in 1959. Paul Dry Books is pleased to return to print this modern travel classic.
Author: Katya Ravid
Publisher: John Wiley & Sons
ISBN: 0471461067
Category : Science
Languages : en
Pages : 640
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Book Description
Transcription Factors Normal and Malignant Development of Blood Cells Katya Ravid and Jonathan Licht The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias. This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as: * Transcription factors and the megakaryocytic, myeloid, and erythroid lineages * Leukemias due to chromosomal translocations involving gene encoding transcription factors * Oncogenesis and hematopoiesis * In vivo studies of transcription factors implicated in hematopoiesis * And much more Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Author: Leonard I. Zon
Publisher: Oxford University Press
ISBN: 9780199771752
Category : Medical
Languages : en
Pages : 864
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Book Description
Hematopoiesis, or the process of blood formation, has been extensively studied at both basic and clinical levels. Human diseases such as thalassemia, immunodeficiency, and leukemia represent defects in this process. Approaches to treat these disorders have required a basic understanding of the biology of blood cells. For instance, hemapoietic stem cell replacement or bone marrow transplantation has been used to ameliorate disease. This volume focuses on hematopoiesis at a cellular and molecular level, and establishes the basis for clinical manipulation of hematopoietic cells for therapeutic benefit. In Part I, the cellular characteristics of progenitors and stem cells are explored. Emphasis is placed on purification of stem cells and both in vitro and in vivo assays. The regulation of normal and leukemis stem cells is illustrated. An excellent discussion of potential use of these cells for gene therapy concludes this section. Hemapoiesis is easily studied during embryogenesis. Part II develops the concept of the waves of hemapoiesis during development. Comparative hematology is making a major comeback as a field in the 1990's. One hope is that general principles of hematopoiesis will be established by studying many models and systems. Part III delves into critical factors that regulate hematopoiesis, including both intracellular and extracellular signals. Part IV and V describe lineage programs for myeloid and lymphoid lineages. These chapters are meant to be illustrative of the different cell fates, but are not exhaustive. Part VI examines the genetics of hematopoisis, particularly in animal models. The hematopoietic system is in constant contact with stromal cells and endothelial cells during development and in the adult. Evidence suggests that endothelial cells and blood cells may arise from a common progenitor, the hemangioblast. Part VII and VIII discuss the stromal and endothelial cells with the emphasis on their interaction with hematopoietic cells.
Author: Jean-Claude Carel
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805579969
Category : Medical
Languages : en
Pages : 242
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Book Description
The body of knowledge in most medical specialties is rapidly expanding, making it virtually impossible to follow all advances in clinical and basic sciences that are relevant to a given field. This is particularly true in pediatric endocrinology, at the cross-road of pediatrics, endocrinology, development and genetics. The 2005 Yearbook of Pediatric Endocrinology brings you a selection of articles that report the year's breakthrough developments in basic sciences and evidence-based new knowledge in clinical research and clinical practice that are relevant to the field. Covering the medical literature published from July 2004 through June 2005, the editors and associate editors selected from several thousand papers those that brought the most meaningful new information, summarized them and provided comments to put them into perspective. The papers are classified into those that identify new genes involved in diseases, new hormones, concepts revised or recentered, important observations for clinical practice, large-scale clinical trials, new mechanisms, new paradigms, important review articles, new fears and new hopes. This is the second volume of the Yearbook of Pediatric Endocrinology, and it is already regarded as a tradition by experts in the field. The Yearbook of Pediatric Endocrinology is endorsed by the European Society for Paediatric Endocrinology (ESPE). We hope that the Yearbook of Pediatric Endocrinology 2005 will help busy clinicians and scientists, pediatric endocrinologists, and also pediatricians and endocrinologists keep informed on new advances in our field.
Author: Olga Babusikova
Publisher: BoD – Books on Demand
ISBN: 9533074000
Category : Medical
Languages : en
Pages : 247
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Book Description
The purpose of this book is to provide a comprehensive review of the scientific advances in T-cell malignancies and to highlight the most relevant findings that will help the reader understand both basic mechanisms of the disease and future directions that are likely to lead to novel therapies. In order to assure a thorough approach to these problems, contributors include basic scientists, translational researchers and clinicians who are experts in this field. Thus, the target audience for this book includes both basic scientists who will use this book as a review of the advances in our fundamental knowledge of the molecular mechanisms of T-cell malignancies, as well as clinicians who will use this book as a tool to understand rationales for the development of novel treatments for these diseases.
Author: Shiro Iuchi
Publisher: Springer Science & Business Media
ISBN: 0387274219
Category : Science
Languages : en
Pages : 291
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Book Description
In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.
Author: David P. Bazett-Jones
Publisher: Springer
ISBN: 3319388827
Category : Science
Languages : en
Pages : 501
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Book Description
This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
Author: Na Luo
Publisher: Frontiers Media SA
ISBN: 2832522815
Category : Science
Languages : en
Pages : 842
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Book Description
Author: Tilman Borggrefe
Publisher: Springer Nature
ISBN: 3031627318
Category :
Languages : en
Pages : 457
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Book Description
