Identification and Characterization of Enigma, a LIM Domain Protein that Interacts with Receptor Tyrosine Kinases PDF Download
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Author: Rui-Yun Wu
Publisher:
ISBN:
Category :
Languages : en
Pages : 266
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Author: Rui-Yun Wu
Publisher:
ISBN:
Category :
Languages : en
Pages : 266
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Author: Linda Wagner Jurata
Publisher:
ISBN:
Category :
Languages : en
Pages : 348
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Author: Shiro Iuchi
Publisher: Springer Science & Business Media
ISBN: 0387274219
Category : Science
Languages : en
Pages : 291
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In the early 1980s, a few scientists started working on a Xenopus transcription factor, TFIIIA. They soon discovered a novel domain associated with zinc, and named this domain "zinc finger. " Th e number of proteins with similar zinc fingers grew quickly and these proteins are now called C2H2, Cys2His2 or classical zinc finger proteins. To date, about 24,000 C2H2 zinc finger proteins have been recognized. Approximately 700 human genes, or more than 2% of the genome, have been estimated to encode C2H2 finger proteins. From the beginning these proteins were thought to be numerous, but no one could have predicted such a huge number. Perhaps thousands of scientists are now working on C2H2 zinc finger proteins fi-om variou s viewpoints. This field is a good example of how a new science begins with the insight of a few scientists and how it develops by efforts of numerous independent scientists, in contrast to a policy-driven scientific project, such as the Human Genome Project, with goals clearly set at its inception and with work performed by a huge collaboration throughout the world. As more zinc finger proteins were discovered, several subfamilies, such as C2C2, CCHC, CCCH, LIM, RING, TAZ, and FYVE emerged, increasing our understanding of zinc fingers. The knowledge was overwhelming. Moreover, scientists began defining the term "zinc finger" differently and using various names for identical zinc fingers. These complications may explain why no single comprehensive resource of zinc finger proteins was available before this publication.
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Category : Dissertation abstracts
Languages : en
Pages : 896
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Author: Alastair D. Reith
Publisher: Springer Science & Business Media
ISBN: 1592590594
Category : Science
Languages : en
Pages : 367
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As key components of many cell signaling pathways, protein kinases are implicated in a broad variety of diseases, including cancers and neurodegenerative conditions, and offer considerable potential as tractable targets for therapeutic intervention. In Protein Kinase Protocols, a panel of highly skilled laboratory investigators describe both basic and more sophisticated methods for the analysis of kinase-mediated signaling cascades, with emphasis on the identification of proteins according to their interactive relationships and the analysis of their functional properties. Described in step-by-step detail, these readily reproducible techniques offer novices quick access to a complicated field, and provide more experienced investigators many novel time-saving ploys. Emphasis is given to the critical technical steps that are often omitted from methods published in the primary literature. There are also tips on potential pitfalls and copious notes on how to adjust the protocols to work in related systems. Broad in its range of techniques and thoroughly detailed to help ensure experimental success, Protein Kinase Protocols offers both novice and experienced investigators powerful tools for understanding the functional roles of specific protein kinases within signaling cascades and for identification and evaluation of novel therapeutic targets.
Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 1340
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Author: Kyle Durick
Publisher:
ISBN:
Category :
Languages : en
Pages : 400
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Author: Gordon Welchman
Publisher: Classic Crypto Books
ISBN: 9780947712341
Category : Language Arts & Disciplines
Languages : en
Pages : 263
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Author:
Publisher:
ISBN:
Category : Dissertations, Academic
Languages : en
Pages : 816
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Author:
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ISBN:
Category : Nucleic acids
Languages : en
Pages : 1030
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