Hyaluronan in Cancer Biology PDF Download
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Author: Robert Stern
Publisher: Academic Press
ISBN: 0080921086
Category : Medical
Languages : en
Pages : 467
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Book Description
Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. - Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer - Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination - Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
Author: Robert Stern
Publisher: Academic Press
ISBN: 0080921086
Category : Medical
Languages : en
Pages : 467
Get Book Here
Book Description
Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. - Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer - Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination - Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
Author: Ik Soo Koh
Publisher: Springer
ISBN: 981136639X
Category : Medical
Languages : en
Pages : 123
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Book Description
This book is a comprehensive, up-to-date, and clearly organized guide to the avoidance, identification, and treatment of complications associated with filler injections. With the aid of a wealth of high-quality illustrations, the various complications that may be encountered when performing filler injections are described and documented. There is a particular focus on granulomas, skin necrosis, and blindness and vision loss, but the full range of less serious complications is also covered, with complete description of the current treatment guidelines for each complication. In addition, the classification of filler complications is clearly explained and regions especially susceptible to adverse events are identified. The book, written by plastic surgeons with vast experience in the field, is exceptional in the breadth and depth of its coverage of filler complications. It will be invaluable for aesthetic and plastic surgeons, dermatologists, and all other providers of filler injections.
Author: Nikolaos Labrou
Publisher: Springer Nature
ISBN: 981137709X
Category : Science
Languages : en
Pages : 388
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Book Description
Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.
Author: Kyle K. Seo
Publisher: Springer Nature
ISBN: 981336212X
Category : Medical
Languages : en
Pages : 283
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Book Description
This book is a comprehensive guide to the use of injectable fillers for facial volumization. Traditionally, fillers have been used for anti-aging purposes such as for wrinkle treatments, but they are increasingly being applied in various ways to achieve beautification such as the augmentation of the nose, chin and lips, leveraging the volumizing effect of fillers. This trend is especially evident in Asian countries but can be expected to flourish elsewhere in the future. The book opens by explaining the specifics of pretreatment assessment and relevant aspects of the basic science of fillers. It then provides a detailed description of the anatomy, injection depth and injection amount relevant to each regional indication, easy to follow for even a novice injector, based on a rich assortment of anatomical illustrations, ultrasound imaging and cadaveric photos provided to assist their understanding. And guidance is also provided on combination treatments in conjunction with botulinum toxin, thread lifting, fat-dissolving injection, etc. Potential complications and countermeasures specific to volumization with fillers are identified. The book features a wealth of illustrations showing the relevant anatomy and before and after appearances, as well as video clips for each indication. Written by a specialist with extensive experience, it provides safe and effective guidance for both beginners and advanced practitioners.
Author: Robert E. Brooks
Publisher:
ISBN:
Category : Hyaluronic acid
Languages : en
Pages : 20
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Book Description
Author: Melvin D. Schoenberg
Publisher:
ISBN:
Category : Hyaluronic acid
Languages : en
Pages : 20
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Book Description
Author: Won Lee
Publisher: Springer Nature
ISBN: 9811668558
Category : Medical
Languages : en
Pages : 80
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Book Description
Filler injection is one of the most common aesthetic procedure. There are a lot of guidelines but there are no illustrated step by step instructions on safe filler injection procedures. The book will offer guidance to clinicians who wish to expand their practice to minimally invasive cosmetic procedures. Injection techniques for hyaluronic acid filler is highlighted to help practitioners perform the procedures more effectively and safely with evidence based approach. The most safe procedure including vascular anatomical illustration and ultrasound findings, rheological data is presented.
Author: Larry W. Moreland
Publisher: Springer Science & Business Media
ISBN: 3540206256
Category : Medical
Languages : en
Pages : 933
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Book Description
Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field
Author: Ajit Varki
Publisher: CSHL Press
ISBN: 9780879696818
Category : Medical
Languages : en
Pages : 694
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Book Description
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author: Theda C. Kontis
Publisher: Thieme
ISBN: 1604067136
Category : Medical
Languages : en
Pages : 249
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Book Description
The injection of cosmetic neurotoxins and fillers is a multi-billion dollar industry in which facial plastic surgeons, plastic surgeons, dermatologists, oculoplastic surgeons, and paraprofessionals in the U.S. perform more than seven million injections annually. Cosmetic Injection Techniques and the videos that accompany it provide all medical professionals in the field (from beginners to experienced injectors) with practical information on how to properly administer neurotoxin and filler injections for conditions such as lower eyelid roll, nasal flare, platysmal banding, marionette lines, glabellar frown lines, and much more. Key Features: Full color, detailed illustrations describe key anatomical landmarks and identify exact injection locations Online access to videos narrated by Dr. Kontis that demonstrate multiple injection techniques A unique rating system for each procedure, enabling injectors to perform techniques appropriate to their skill level Every commonly performed cosmetic injection procedure is covered, giving readers a comprehensive guide on how to safely and effectively perform injections This easy-to-use manual gives facial plastic surgeons, plastic surgeons, dermatologists, oculoplastic surgeons and other medical professionals authoritative, concise information on the anatomy, techniques, precautions, complications, and post-treatment care involved in the administration of injections of cosmetic neurotoxins and fillers.
