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Author: Victor M. Rios
Publisher: University of Chicago Press
ISBN: 022609099X
Category : Education
Languages : en
Pages : 220
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Book Description
Victor Rios has a vibrant reputation as America s leading ethnographer of Latino youth. His personal storygoing from drug pusher (selling heroin on the streets as a teenager) to a hard worker at a mechanic shop within a matter of weeksshows how he stands in the place of the Latino youths he studies. His story underscores the degree to which delinquent urban youths can become adaptable, fluid, amenable individuals, able to shift their views of the world as well as their actions. Rios rejects the old storyline that said gangs are bad and they do bad things because they are bad people. Kids on the street, he argues, can drift between different identities, indeed, they can shift seamlessly between responsible and deviant displays within a few hours time. The key to understanding gang-associated youth lies in analysis of the way authority figures (teachers and police officers) interact with young people. The kids need caring adults who offer tangible resources. Story and characters are always front-and-center in Rios s narrative: Jorge, Mark, Wilson, and others, are boys we get to know as they negotiate day-to-day life on the streets and across institutional settings. We learn a great deal about Cholo subculture, the clothing and hairstyles, and the argot that are adopted by Latino youth in response to the forces that seek to marginalize or punish them. The crisis of a perceived epidemic of police brutality in our post-Ferguson era is a product of culture in Rios s view: contested symbols, negative interactions, and day-to-day encounters that freeze youth identities as gang-associated, and that freeze authority identities as negative shapers of youth attitudes and actions are the dynamic. Fear of young males of color leads to police misreading and dehumanizing of young black and Latino men. Rios raises our awareness of how this dynamic operates by studying his subjects whole: following young gang members into their schools, their homes, their community organizations, their detention facilities, and watching them interact with police, watching them grow up to become fathers, get jobs, get rap sheets. Get killed. This book will be a landmark contribution to the social psychology of poverty and crime."
Author: Victor M. Rios
Publisher: University of Chicago Press
ISBN: 022609099X
Category : Education
Languages : en
Pages : 220
Get Book Here
Book Description
Victor Rios has a vibrant reputation as America s leading ethnographer of Latino youth. His personal storygoing from drug pusher (selling heroin on the streets as a teenager) to a hard worker at a mechanic shop within a matter of weeksshows how he stands in the place of the Latino youths he studies. His story underscores the degree to which delinquent urban youths can become adaptable, fluid, amenable individuals, able to shift their views of the world as well as their actions. Rios rejects the old storyline that said gangs are bad and they do bad things because they are bad people. Kids on the street, he argues, can drift between different identities, indeed, they can shift seamlessly between responsible and deviant displays within a few hours time. The key to understanding gang-associated youth lies in analysis of the way authority figures (teachers and police officers) interact with young people. The kids need caring adults who offer tangible resources. Story and characters are always front-and-center in Rios s narrative: Jorge, Mark, Wilson, and others, are boys we get to know as they negotiate day-to-day life on the streets and across institutional settings. We learn a great deal about Cholo subculture, the clothing and hairstyles, and the argot that are adopted by Latino youth in response to the forces that seek to marginalize or punish them. The crisis of a perceived epidemic of police brutality in our post-Ferguson era is a product of culture in Rios s view: contested symbols, negative interactions, and day-to-day encounters that freeze youth identities as gang-associated, and that freeze authority identities as negative shapers of youth attitudes and actions are the dynamic. Fear of young males of color leads to police misreading and dehumanizing of young black and Latino men. Rios raises our awareness of how this dynamic operates by studying his subjects whole: following young gang members into their schools, their homes, their community organizations, their detention facilities, and watching them interact with police, watching them grow up to become fathers, get jobs, get rap sheets. Get killed. This book will be a landmark contribution to the social psychology of poverty and crime."
Author: Edward D. Zanders
Publisher: John Wiley & Sons
ISBN: 111884985X
Category : Science
Languages : en
Pages : 454
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Book Description
The identification of drug targets in a given disease has been central to pharmaceutical research from the latter half of the 20th century right up to the modern genomics era. Human Drug Targets provides an essential guide to one of the most important aspects of drug discovery – the identification of suitable protein and RNA targets prior to the creation of drug development candidates. The first part of the book consists of introductory chapters that provide the background to drug target discovery and highlight the way in which these targets have been organised into online databases. It also includes a user’s guide to the list of entries that forms the bulk of the book. Since this is not designed to be a compendium of drugs, the emphasis will be on the known (or speculated) biological role of the targets and not on the issues associated with pharmaceutical development. The objective is to provide just enough information to be informative and prompt further searches, while keeping the amount of text for each of the many entries to a minimum. Human Drug Targets will prove invaluable to those drug discovery professionals, in both industry and academia, who need to make some sense of the bewildering array of online information sources on current and potential human drug targets. As well as creating order out of a complex target landscape, the book will act as an ideas generator for potentially novel targets that might form the basis of future discovery projects.
Author: Eve Ensler
Publisher: Dramatists Play Service Inc
ISBN: 9780822218951
Category : Drama
Languages : en
Pages : 52
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Book Description
THE STORY: In NECESSARY TARGETS, two American women, a Park Avenue psychiatrist and an ambitious young writer, travel to Bosnia to help women refugees confront their memories of war. Though the two have little in common beyond the methods they use
Author: Cameron H. Malin
Publisher: Elsevier
ISBN: 0124116396
Category : Computers
Languages : en
Pages : 286
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Book Description
Deception in the Digital Age: Exploiting and Defending Human Targets Through Computer-Mediated Communication guides readers through the fascinating history and principles of deception—and how these techniques and stratagems are now being effectively used by cyber attackers. Users will find an in-depth guide that provides valuable insights into the cognitive, sensory and narrative bases of misdirection, used to shape the targeted audience's perceptions and beliefs. The text provides a detailed analysis of the psychological, sensory, sociological, and technical precepts that reveal predictors of attacks—and conversely postmortem insight about attackers—presenting a unique resource that empowers readers to observe, understand and protect against cyber deception tactics. Written by information security experts with real-world investigative experience, the text is the most instructional book available on the subject, providing practical guidance to readers with rich literature references, diagrams and examples that enhance the learning process. - Deeply examines the psychology of deception through the lens of misdirection and other techniques used by master magicians - Explores cognitive vulnerabilities that cyber attackers use to exploit human targets - Dissects the underpinnings and elements of deception narratives - Examines group dynamics and deception factors in cyber attacker underground markets - Provides deep coverage on how cyber attackers leverage psychological influence techniques in the trajectory of deception strategies - Explores the deception strategies used in today's threat landscape—phishing, watering hole, scareware and ransomware attacks - Gives unprecedented insight into deceptive Internet video communications - Delves into the history and deception pathways of nation-state and cyber terrorism attackers - Provides unique insight into honeypot technologies and strategies - Explores the future of cyber deception
Author: Luis M. Botana
Publisher: John Wiley & Sons
ISBN: 1118185528
Category : Medical
Languages : en
Pages : 503
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Book Description
The Latest Applications For Cellmechanism Research in Drug Discovery Designed to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe. The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more. Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
Author: Felix Müller
Publisher: Springer Science & Business Media
ISBN: 9783540636793
Category : Mathematics
Languages : en
Pages : 648
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Book Description
This volume comprises the proceedings of the International Workshop on Eco logical Goal Functions, held at the Schleswig-Holstein Cultural Center of Salzau, August 30 -September 4, 1996. The conference - first in a series - intended to be convened at Salzau at 1 -2 year intervals to address various aspects of theo retical and application-oriented ecology, was initiated, organized and carried out under the auspices of the Ecology Center of the Kiel University. It featured key note addresses, invited lectures, submitted papers, and posters. 32 contributions written by authors from eight countries, were selected to be presented in this book. From the very rich discussions of the workshop, some general characteristics emerged which might become important for a deeper understanding of the nature of evolving systems or, in other words, systems with a history, described by variables with a high degree of interdependence. These characteristics include the following: Speaking of 'goal functions' is a convenient 'fa~on de parler', since a logical analysis of the formal structure of teleological and causal explanations shows that both are analogous with regard to the inherent structural typology and the basic mode of explanation. Teleological interpretations introduce motives or objectives of actors into the set of 'antecedens' conditions relevant for system evolution, and are consequently a subset of causal interpretations.
Author: Carlos Alonso Escudero
Publisher: Frontiers Media SA
ISBN: 2889194612
Category : Science (General)
Languages : en
Pages : 114
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Book Description
A large number of publications have described impaired angiogenesis and vasculogenesis present in the feto-placental circulation after pregnancy diseases such as pre-eclamptic pregnancies, gestational diabetes, and intrauterine growth restriction, among others. Results suggest impaired secretion and activity of pro-angiogenic factors such as vascular endothelial growth factor (VEGF), interleukin 8 (IL-8), adenosine and nitric oxide, associates with compromised secretion and activity of anti-angiogenic factors such as soluble receptor of VEGF (sFlt-1), thrombospondin 2, endostatin among others. More recent evidences include the participation of endothelial progenitor cells (EPC), which circulating number is reduced infeto-placental circulation in pregnancies such as pre-eclampsia. Despite this knowledge, therapies for placental angiogenesis recovery during pathological pregnancies are far to be tested. However, from the cardiovascular field, it has been described the administration of EPC, alone or used as gene-transfer therapy; or it has been described the potential role of statins (HMGCoA inhibitors), or angiotensin-converter enzyme (ACE) inhibitors for enhancing angiogenesis. Finally, feto-placental tissue is an exceptional source of progenitor and stem cells, which could be used for treated other human diseases such as stroke, myocardial infarction, hypertension, or even cancer. In this research topic, authors highlight physiopatological and clinical importance of the impaired placental angiogenesis, and suggest potential targets for developing innovative therapies.
Author: Madhathilkovilakathu Haridas
Publisher: Springer Nature
ISBN: 9819991838
Category :
Languages : en
Pages : 572
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Book Description
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309292492
Category : Medical
Languages : en
Pages : 107
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Book Description
Improving and Accelerating Therapeutic Development for Nervous System Disorders is the summary of a workshop convened by the IOM Forum on Neuroscience and Nervous System Disorders to examine opportunities to accelerate early phases of drug development for nervous system drug discovery. Workshop participants discussed challenges in neuroscience research for enabling faster entry of potential treatments into first-in-human trials, explored how new and emerging tools and technologies may improve the efficiency of research, and considered mechanisms to facilitate a more effective and efficient development pipeline. There are several challenges to the current drug development pipeline for nervous system disorders. The fundamental etiology and pathophysiology of many nervous system disorders are unknown and the brain is inaccessible to study, making it difficult to develop accurate models. Patient heterogeneity is high, disease pathology can occur years to decades before becoming clinically apparent, and diagnostic and treatment biomarkers are lacking. In addition, the lack of validated targets, limitations related to the predictive validity of animal models - the extent to which the model predicts clinical efficacy - and regulatory barriers can also impede translation and drug development for nervous system disorders. Improving and Accelerating Therapeutic Development for Nervous System Disorders identifies avenues for moving directly from cellular models to human trials, minimizing the need for animal models to test efficacy, and discusses the potential benefits and risks of such an approach. This report is a timely discussion of opportunities to improve early drug development with a focus toward preclinical trials.
Author: Margaret Atwood
Publisher: House of Anansi
ISBN: 9780887847356
Category : Canadian literature
Languages : en
Pages : 440
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Book Description
The most precious treasure of this collection is that it gives us the rich back-story and diverse range of influences on Margaret Atwood's work. From the aunts who encouraged her nascent writing career to the influence of George Orwell's Nineteen Eighty-Four on The Handmaid's Tale, we trace the movement of Atwood's fertile and curious mind in action over the years.Atwood's controversial political pieces, Napoleon's Two Biggest Mistakes and Letter to America -- both not-so-veiled warnings about the repercussions of the war in Iraq -- also appear, alongside pieces that exhibit her active concern for the environment, the North, and the future of the human race. Atwood also writes about her peers: John Updike, Marina Warner, Italo Calvino, Marian Engel, Toni Morrison, Angela Carter, Gabriel Garcia Marquez, Mordecai Richler, Elmore Leonard, and Ursula Le Guin.This is a landmark volume from a major writer whose worldwide readership is in the millions, and whose work has influenced and entertained generations. Moving Targets is the companion volume to Second Words.
