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Author: John M. Coffin
Publisher: CSHL Press
ISBN: 9780879695712
Category : Medical
Languages : en
Pages : 856
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Book Description
For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
Author: John M. Coffin
Publisher: CSHL Press
ISBN: 9780879695712
Category : Medical
Languages : en
Pages : 856
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Book Description
For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
Author: William A. Blattner
Publisher: Raven Press (ID)
ISBN:
Category : Medical
Languages : en
Pages : 520
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Book Description
Author: Jörg Schüpbach
Publisher: Springer Science & Business Media
ISBN: 3642751954
Category : Medical
Languages : en
Pages : 121
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Book Description
This book gives a concise review of the known human retroviruses; the onco-retroviruses HTLV-1 and -2 and the AIDS-associated lentiviruses HIV-1 and -2. History, classification, general and genomic structure, and basic biologic facts of retroviruses are described in introductory chapters. Subsequent chapters deal with the epidemiology, disease spectrum, structure and functions of the viral genes and proteins of the individual viruses. A separate chapter describes the various humoral and cellular immune mechanisms in response to HIV and their use with respect to diagnosis and treatment. Special attention is given to the complicated pathogenesis of AIDS and the consequences with regard to therapy and vaccination. The book ends with a critical review of recent work suggesting a possible role of still other retroviruses in human disorders including malignancies, autoimmune, or neurologic diseases. The book is designed to give the reader a broad, but detailed view of human retroviruses and the diseases associated with them. It tries to connect the viral, immunologic, and pathologic aspects of these infections to unifying concepts - no quick answers though, but profound critical information on a complicated topic.
Author: Reinhard Kurth
Publisher: Caister Academic Press Limited
ISBN: 9781904455554
Category : Science
Languages : en
Pages : 0
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Book Description
Leading scientists in the field review the genomics, molecular biology and pathogenesis of these important viruses, comprehensively covering all the recent advances.
Author: Kent Heckenlively
Publisher: Simon and Schuster
ISBN: 1510726357
Category : Science
Languages : en
Pages : 604
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Book Description
On July 22, 2009, a special meeting was held with twenty-four leading scientists at the National Institutes of Health to discuss early findings that a newly discovered retrovirus was linked to chronic fatigue syndrome (CFS), prostate cancer, lymphoma, and eventually neurodevelopmental disorders in children. When Dr. Judy Mikovits finished her presentation the room was silent for a moment, then one of the scientists said, “Oh my God!” The resulting investigation would be like no other in science. For Dr. Mikovits, a twenty-year veteran of the National Cancer Institute, this was the midpoint of a five-year journey that would start with the founding of the Whittemore-Peterson Institute for Neuro-Immune Disease at the University of Nevada, Reno, and end with her as a witness for the federal government against her former employer, Harvey Whittemore, for illegal campaign contributions to Senate Majority Leader Harry Reid. On this journey Dr. Mikovits would face the scientific prejudices against CFS, wander into the minefield that is autism, and through it all struggle to maintain her faith in God and the profession to which she had dedicated her life. This is a story for anybody interested in the peril and promise of science at the very highest levels in our country.
Author: Anna Marie Skalka
Publisher: Harvard University Press
ISBN: 0674988752
Category : Science
Languages : en
Pages : 193
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Book Description
Approximately eight percent of our DNA contains retroviral sequences that are millions of years old. Through engaging stories of scientific discovery, Anna Marie Skalka explains our evolving knowledge of these ancient denizens of the biosphere and how this understanding has significantly advanced research in genetic engineering, gene delivery systems, and precision medicine. Discovering Retroviruses begins with the pioneer scientists who first encountered these RNA-containing viruses and solved the mystery of their reproduction. Like other viruses, retroviruses invade the cells of a host organism to reproduce. What makes them “retro” is a unique process of genetic information transfer. Instead of transcribing DNA into RNA as all living cells do, they transcribe their RNA into DNA. This viral DNA is then spliced into the host’s genome, where the cell’s synthetic machinery is co-opted to make new virus particles. The 100,000 pieces of retroviral DNA in the human genome are remnants from multiple invasions of our ancestors’ “germline” cells—the cells that allow a host organism to reproduce. Most of these bits of retroviral DNA are degenerated fossils, but some have been exploited during evolution, with profound effects on our physiology. Some present-day circulating retroviruses cause cancers in humans and other animals. Others, like HIV, cause severe immunodeficiencies. But retroviruses also hold clues to innovative approaches that can prevent and treat these diseases. In laboratories around the world, retroviruses continue to shed light on future possibilities that are anything but “retro.”
Author: Robert C. Gallo
Publisher: Basic Books
ISBN: 9780465098156
Category : Science
Languages : en
Pages : 0
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Book Description
The renowned AIDS researcher Robert Gallo tells his story of scientific breakthrough in a riveting portrait of the people, the politics, and the pace of modern scientific discovery.
Author: Robert C. Gallo
Publisher: Elsevier
ISBN: 0080918328
Category : Science
Languages : en
Pages : 440
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Book Description
This book presents twenty-four tightly focused reviews on the biology, molecular biology, pathology, and epidemiology of the human retroviruses, particularly HIV and HTLV (Types I and II), as well as animal model systems (simian retroviruses, STLV and SIV, and mouse models).Editor Robert C. Gallo is recognized as a co-discoverer of the AIDS virus.
Author: Axel Rethwilm
Publisher: Springer Science & Business Media
ISBN: 9783540443889
Category : Medical
Languages : en
Pages : 232
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Book Description
The aberrant replication pathway of foamy viruses distinguishes them from all other retroviruses. Many details have been accumulated over the past ten or so years. Most of the findings on foamy viruses were obtained by research on a single virus isolate previously called "human foamy virus", which appeared to be the first to be investigated on a molecular level. However, to the editor's knowledge, genuine human foamy viruses do not exist, but several trans-species transmissions of different simian foamy viruses from monkeys and apes to human hosts.
Author: Lawrence C. Kuo
Publisher: Gulf Professional Publishing
ISBN: 9780121821425
Category : Medical
Languages : en
Pages : 494
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Book Description
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
