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Author: Jörg Schüpbach
Publisher: Springer Science & Business Media
ISBN: 3642751954
Category : Medical
Languages : en
Pages : 121
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Book Description
This book gives a concise review of the known human retroviruses; the onco-retroviruses HTLV-1 and -2 and the AIDS-associated lentiviruses HIV-1 and -2. History, classification, general and genomic structure, and basic biologic facts of retroviruses are described in introductory chapters. Subsequent chapters deal with the epidemiology, disease spectrum, structure and functions of the viral genes and proteins of the individual viruses. A separate chapter describes the various humoral and cellular immune mechanisms in response to HIV and their use with respect to diagnosis and treatment. Special attention is given to the complicated pathogenesis of AIDS and the consequences with regard to therapy and vaccination. The book ends with a critical review of recent work suggesting a possible role of still other retroviruses in human disorders including malignancies, autoimmune, or neurologic diseases. The book is designed to give the reader a broad, but detailed view of human retroviruses and the diseases associated with them. It tries to connect the viral, immunologic, and pathologic aspects of these infections to unifying concepts - no quick answers though, but profound critical information on a complicated topic.
Author: Jörg Schüpbach
Publisher: Springer Science & Business Media
ISBN: 3642751954
Category : Medical
Languages : en
Pages : 121
Get Book Here
Book Description
This book gives a concise review of the known human retroviruses; the onco-retroviruses HTLV-1 and -2 and the AIDS-associated lentiviruses HIV-1 and -2. History, classification, general and genomic structure, and basic biologic facts of retroviruses are described in introductory chapters. Subsequent chapters deal with the epidemiology, disease spectrum, structure and functions of the viral genes and proteins of the individual viruses. A separate chapter describes the various humoral and cellular immune mechanisms in response to HIV and their use with respect to diagnosis and treatment. Special attention is given to the complicated pathogenesis of AIDS and the consequences with regard to therapy and vaccination. The book ends with a critical review of recent work suggesting a possible role of still other retroviruses in human disorders including malignancies, autoimmune, or neurologic diseases. The book is designed to give the reader a broad, but detailed view of human retroviruses and the diseases associated with them. It tries to connect the viral, immunologic, and pathologic aspects of these infections to unifying concepts - no quick answers though, but profound critical information on a complicated topic.
Author: John M. Coffin
Publisher: CSHL Press
ISBN: 9780879695712
Category : Electronic books
Languages : en
Pages : 856
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Book Description
For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
Author: Jorg Schupbach
Publisher:
ISBN: 9783642751967
Category :
Languages : en
Pages : 124
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Book Description
Author: Mariana Warne
Publisher:
ISBN: 9781632416575
Category :
Languages : en
Pages : 282
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Book Description
The type of RNA viruses which insert a copy of their genome into the DNA of the host cells that they invade, and consequently change the genome of, are called retroviruses. After entering the host cell's cytoplasm, the retroviruses use their own reverse transcriptase enzyme to produce DNA from their RNA genome. The study of retroviruses and the diseases caused by them, is called retrovirology. Retroviruses, including Mouse mammary and Rous sarcoma virus can cause diseases, like tumor and cancer. The transmission of retroviruses can be airborne, from cell-to-cell, or through fluids. Antiretroviral drugs are the common medications used for treating the infection caused by retroviruses. This book elucidates the concepts and innovative models around prospective developments with respect to human retrovirology. It includes some of the vital pieces of work being conducted across the world, on various topics related to human retrovirology. This book will help new researchers by foregrounding their knowledge in this branch.
Author: William A. Blattner
Publisher: Raven Press (ID)
ISBN:
Category : Medical
Languages : en
Pages : 520
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Book Description
Author: Robert C. Gallo
Publisher: Springer Science & Business Media
ISBN: 1461250080
Category : Medical
Languages : en
Pages : 551
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Book Description
For decades retroviruses have been riding the crest of a wave of experimental research directed toward the identification of an infectious agent of human neoplastic diseases. In the early 1970s, several scientists successfully demonstrated the presence of retroviruses in numerous animal species and proved their etiological role in some related diseases. Corresponding findings in humans were somewhat discouraging. Although financial support for this line· of research declined, a few dedicated retrovirologists survived and continued to collect more biological information and technological expertise that opened a new approach to the search for a human retrovirus. The rewards came with the discovery that the genes responsible for neoplastic transformation (oncogenes) are of cellular origin and can be shuttled about by retroviruses, and with the identification of a new family of Human T-cell Lymphotrophic retroViruses (HTLV) from patients with diseases ranging from leukemia to the acquired immunodeficiency syndrome (AIDS). An understanding of the role and significance of retroviruses in human pathology requires basic knowledge of the major animal systems studied. With this perspective in mind, we present here a survey that includes general overviews, minireviews on each animal system studied with selected experimental reports and, finally, a stimulating review of the field of human retrovirology by many of the pioneer scientists who created it. We are especially grateful to Profs. C. A. Romanzi and G. C. Schito for promoting the organization of the Symposium. On behalf of the Sym posium Committee, we thank E. Soeri, L. Casarino, G. P. Gesu, M.
Author: Reinhard Kurth
Publisher: Caister Academic Press Limited
ISBN: 9781904455554
Category : Science
Languages : en
Pages : 0
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Book Description
Leading scientists in the field review the genomics, molecular biology and pathogenesis of these important viruses, comprehensively covering all the recent advances.
Author: Robert C. Gallo
Publisher: Elsevier
ISBN: 0080918328
Category : Science
Languages : en
Pages : 440
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Book Description
This book presents twenty-four tightly focused reviews on the biology, molecular biology, pathology, and epidemiology of the human retroviruses, particularly HIV and HTLV (Types I and II), as well as animal model systems (simian retroviruses, STLV and SIV, and mouse models).Editor Robert C. Gallo is recognized as a co-discoverer of the AIDS virus.
Author: Tuofu Zhu
Publisher: Springer Science & Business Media
ISBN: 1592599079
Category : Science
Languages : en
Pages : 488
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Book Description
A cutting-edge collection of basic and state-of-the-art methods optimized for investigating the molecular biology of this class of retrovirus. These readily reproducible techniques range from methods for the isolation and detection of human retroviruses to cutting-edge methods for exploring the interplay between the viruses and the host. Here, the researcher will find up-to-date techniques for the isolation and propagation of HIV, HTLV, and foamy virus from a variety of sources. There are also assays for determining the cell tropism of HIV-1, the coreceptor usage of HIV-1, and human gene expression with HIV-1 infection by microarrays, as well as for phenotyping HIV-1 infected monocytes and examining their fitness. Highlights include the detection and quantification of HIV-1 in resting CD4+, a new cloning system for making recombinent virus, cDNA microarrays, and the determination of genetic polymorphisms in two recently identified HIV-1 co-factors that are critical for HIV-1 infection.
Author: Elisa Vicenzi
Publisher: Humana
ISBN: 9781493962587
Category : Medical
Languages : en
Pages : 0
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Book Description
Human Retroviruses: Methods and Protocols collects key experimental protocols that have provided the basis of the major discoveries of the field. Split into five sections, this detailed volume covers mapping of the HIV life cycle, isolation, co-receptor use, and cell tropism of HIV-1, in vivo quantification of HIV-1, biological aspects of HIV-1, as well as HTLVs. Some articles explore “assay and function of accessory genes”, largely involving the interface between retroviral and host factors, the extracellular role of Tat and Tax, resembling the function of cytokines, and the biotechnological exploitation of HIV as lentiviral vector to carry foreign genes with therapeutic value. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Human Retroviruses: Methods and Protocols provides state-of-art methodological protocols from world leaders in human retrovirology, essential for any lab working this vital field.
