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Author: Amanullah Khan
Publisher: Elsevier
ISBN: 0323142672
Category : Medical
Languages : en
Pages : 756
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Book Description
Human Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17, 1981 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors explore the role of human lymphokines in immune responses and their applications in immunotherapy. The focus is on lymphokines that have either entered clinical trials or are nearing clinical evaluation. Some of the activities of possible immediate significance, such as Glia cell stimulating factor and polyclonal B-cell activator, are also described. This volume is organized into six sections encompassing 56 chapters and begins with an overview of assay systems, touching on topics such as the activation of macrophages by interferon to produce plasminogen and macrophage activation by lymphokine factors. The next sections turn to the production, purification, and biological and chemical characterization of lymphokines. The discussion then shifts to the mechanisms of action of lymphokines in vitro and the use of animal models in lymphokine investigations, including lymphokine fractions in a mouse tumor model and enhancement of natural killing activity by different types of interferon. A great deal of emphasis is placed on macrophage migration inhibitory factor, lymphotoxins, gamma interferon, and interleukins. The book concludes with chapters devoted to the immunoregulatory effects of lymphokines and clinical studies.
Author: Amanullah Khan
Publisher: Elsevier
ISBN: 0323142672
Category : Medical
Languages : en
Pages : 756
Get Book Here
Book Description
Human Lymphokines: The Biological Immune Response Modifiers is a collection of papers presented at the Third International Symposium on Human Lymphokines held on October 15-17, 1981 at the Wadley Institutes of Molecular Medicine in Dallas, Texas. Contributors explore the role of human lymphokines in immune responses and their applications in immunotherapy. The focus is on lymphokines that have either entered clinical trials or are nearing clinical evaluation. Some of the activities of possible immediate significance, such as Glia cell stimulating factor and polyclonal B-cell activator, are also described. This volume is organized into six sections encompassing 56 chapters and begins with an overview of assay systems, touching on topics such as the activation of macrophages by interferon to produce plasminogen and macrophage activation by lymphokine factors. The next sections turn to the production, purification, and biological and chemical characterization of lymphokines. The discussion then shifts to the mechanisms of action of lymphokines in vitro and the use of animal models in lymphokine investigations, including lymphokine fractions in a mouse tumor model and enhancement of natural killing activity by different types of interferon. A great deal of emphasis is placed on macrophage migration inhibitory factor, lymphotoxins, gamma interferon, and interleukins. The book concludes with chapters devoted to the immunoregulatory effects of lymphokines and clinical studies.
Author: Stanley Cohen
Publisher: Academic Press
ISBN: 1483271420
Category : Medical
Languages : en
Pages : 645
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Book Description
Biology of the Lymphokines discusses the scope and diversity of lymphokine research. This book focuses on the studies on lymphokines, such as those involving cellular source, chemical nature, purification strategies, and bioassay limitations. The mechanism of lymphokine action, lymphokines in vivo, and value of lymphokine quantitations are also covered. This text describes the repertoire of lymphokines produced by various lymphoblastoid cell lines and its significance for coping with the problem of large scale lymphokine production. The anti-viral and general immunoregulatory properties of interferons and rationale developed for integrating interferons with the family of lymphokines are likewise deliberated. This publication is a good source for students and researchers conducting work on lymphokines.
Author: Edgar Pick
Publisher: Elsevier
ISBN: 1483266990
Category : Science
Languages : en
Pages : 473
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Book Description
Lymphokines: A Forum for Immunoregulatory Cell Products deals with immunoregulatory cell products that produce lymphokines. Topics covered include the purification and characterization of transfer factor; activation of cytotoxicity and/or suppressor activity in murine macrophages by lymphokines, lipopolysaccharide, and polyinosinic-polycytidylic acid; and the role of clotting processes in the action of lymphokines on macrophages. A comparison of the immune-modulating effects of interferon and interferon inducers is also presented. Comprised of 13 chapters, this volume begins with a discussion on transfer factor and its ability to react specifically with antigens. The clinical uses of transfer factor are considered with special emphasis on its value as a prophylactic agent. The reader is then introduced to the subject of T cell regulation of the immunoglobulin E (IgE) response via potentiating and suppressor lymphokines, together with the possible clinical application of IgE suppressive factors in the treatment of atopic diseases. Subsequent chapters examine the evidence in favor of the existence of T cell-derived polyclonal B cell activator (PBA) playing a role in both normal antibody responses and autoimmune diseases; the role of suppressor T cells and the associated lymphokines in contact sensitivity in mice; and lymphokine action on macrophages. The book also analyzes the genetics of the response of human and mouse cells to interferons. This monograph will be helpful to practitioners and researchers in the fields of microbiology and immunology.
Author: Stanley Cohen
Publisher: CRC Press
ISBN: 9780849364273
Category : Medical
Languages : en
Pages : 292
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Book Description
This book provides a broad overview of all aspects of modern lymphokine research. It begins with the ways in which lymphokines play a role in the activation of the immune response and concludes with their participation in various facets of host defense. It devotes special attention to structure, mechanism of action, and range application. In addition, this fascinating work also shows how lymphokines are involved in other physiologic responses, such as reparative reactions involving fibrosis and angiogenesis. This is an excellent resource for students and investigators in the biomedical sciences, as well as clinicians who require up-to-date information about our current understanding of immune processes.
Author: Klaus Bendtzen
Publisher:
ISBN:
Category : Lymphokines
Languages : en
Pages : 48
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Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author:
Publisher: ScholarlyEditions
ISBN: 146494282X
Category : Medical
Languages : en
Pages : 57
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Book Description
Lymphokines: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Lymphokines in a concise format. The editors have built Lymphokines: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Lymphokines in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Lymphokines: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author: David R. Webb
Publisher: Springer Science & Business Media
ISBN: 1461245982
Category : Medical
Languages : en
Pages : 495
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Book Description
The Fifth International Lymphokine Workshop was convened in Clearwater Beach, Florida, January 11-15, 1987. The theme chosen for the meeting was 'The Molecular Basis of Lymphokine Action," which reflected the opinion of the organizers as to how far the field had moved since the first Lymphokine Workshop only eleven years ago. As was evident at the last Lymphokine Workshop held in 1985, the contribution of molecular biology, particularly in the cloning of lymphokine genes, continues to play an important role in clarifying the structure of lymphokines, providing recombinant (read "pure") proteins for biological studies, and suggesting directions for studies of the molecular basis of lymphokine activity. The most recent lymphokines to yield to molecular cloning meth odology were the B-cell growth and differentiation factors, in partic ular BSF-1 or, as it is sometimes termed, interleukin 4. One of the surprises from this research is the broad spectrum of activities that can be attributed to this molecule, aside from its effects on B-cells, thus perhaps justifying its being called an interleukin. The interleukin 2 symposium demonstrated that even in a well-established research area, controversy and excitement can continue, when evidence was presented by several investigators indicating the presence of a second "converter" protein that changes the affinity of the now classical Tac antigen from a low to a high affinity IL-2 receptor.
Author: Allan Goldstein
Publisher: Springer Science & Business Media
ISBN: 1468447459
Category : Science
Languages : en
Pages : 643
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Book Description
The Third Annual Symposium on Health Sciences attracted over 400 scientists from 15 countries. It was held at the National Academy of Sciences in Washington, D.C. The theme of this meeting was "Thymic Hormones and Lymphokines: Basic Chem istry and Clinical Applications." The meeting emphasized the state of the art with regard to chemistry, mech anism of action, and clinical applications of thymic hormones and lymphokines. In addition to the five sessions, the chairmen of each session were asked to prepare a synthesis and overview of each of the sessions. Some of the chairmen used this time to summarize the new material presented while others addressed important areas of conflict and terminology. The chairmen of the plenary sessions prepared short summary papers which have been incorporated into this volume at the end of each major section. We also invited several of the scientists who took part in the poster presentations to submit short papers. In addition to the scientific sessions, there were two awards and lectures. One, the Abraham White Distinguished Science Award, was given to Dr. Robert C. Gallo, who gave the keynote lecture. He was recognized for his pioneering research and scientific contributions to our understanding of the regulation of hematopoietic cell differentiation and the role of viruses in the development of human leukemias.
Author: Allan Goldstein
Publisher: Springer
ISBN: 9781468447477
Category : Science
Languages : en
Pages : 669
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Book Description
The Third Annual Symposium on Health Sciences attracted over 400 scientists from 15 countries. It was held at the National Academy of Sciences in Washington, D.C. The theme of this meeting was "Thymic Hormones and Lymphokines: Basic Chem istry and Clinical Applications." The meeting emphasized the state of the art with regard to chemistry, mech anism of action, and clinical applications of thymic hormones and lymphokines. In addition to the five sessions, the chairmen of each session were asked to prepare a synthesis and overview of each of the sessions. Some of the chairmen used this time to summarize the new material presented while others addressed important areas of conflict and terminology. The chairmen of the plenary sessions prepared short summary papers which have been incorporated into this volume at the end of each major section. We also invited several of the scientists who took part in the poster presentations to submit short papers. In addition to the scientific sessions, there were two awards and lectures. One, the Abraham White Distinguished Science Award, was given to Dr. Robert C. Gallo, who gave the keynote lecture. He was recognized for his pioneering research and scientific contributions to our understanding of the regulation of hematopoietic cell differentiation and the role of viruses in the development of human leukemias.
