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Author: G.R. Honig
Publisher: Springer Science & Business Media
ISBN: 3709187982
Category : Medical
Languages : en
Pages : 460
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Book Description
The discovery in the late 1940's that sickle cell anemia is a "molecular disease" of hemoglobin was the crucial advance that gave birth to the scientific discipline of human molecular genetics. In subsequent years, with the continued expansion of knowledge about the biology and genetics of the hemoglobins, and particularly as a result of the characterization of the very large numbers of globin gene mutations, the human hemoglobin system has remained as the premier model of gene expression at the molecular level in man. With the recent explosion of new information about the genetic properties of the hemoglobins, it appears inevitable that this gene system will continue to occupy a unique position in human molecular genetics for many years in the future. Hemoglobin genetics has also recently come of age as a diagnostic and clinical discipline. The heightening of public awareness in recent years about sickle cell disease, thalassemia, and other inherited disorders has brought increasing demands for carrier detection services as well as for genetic counseling and education. The more recent development of prac tical and reliable methods for the antenatal diagnosis of hemoglobin dis orders has further increased the scope of clinical hemoglobin genetics, and it can be anticipated that these potent diagnostic techniques will have increasing application in the years ahead.
Author: G.R. Honig
Publisher: Springer Science & Business Media
ISBN: 3709187982
Category : Medical
Languages : en
Pages : 460
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Book Description
The discovery in the late 1940's that sickle cell anemia is a "molecular disease" of hemoglobin was the crucial advance that gave birth to the scientific discipline of human molecular genetics. In subsequent years, with the continued expansion of knowledge about the biology and genetics of the hemoglobins, and particularly as a result of the characterization of the very large numbers of globin gene mutations, the human hemoglobin system has remained as the premier model of gene expression at the molecular level in man. With the recent explosion of new information about the genetic properties of the hemoglobins, it appears inevitable that this gene system will continue to occupy a unique position in human molecular genetics for many years in the future. Hemoglobin genetics has also recently come of age as a diagnostic and clinical discipline. The heightening of public awareness in recent years about sickle cell disease, thalassemia, and other inherited disorders has brought increasing demands for carrier detection services as well as for genetic counseling and education. The more recent development of prac tical and reliable methods for the antenatal diagnosis of hemoglobin dis orders has further increased the scope of clinical hemoglobin genetics, and it can be anticipated that these potent diagnostic techniques will have increasing application in the years ahead.
Author: Martin H. Steinberg
Publisher: Cambridge University Press
ISBN: 0521875196
Category : Medical
Languages : en
Pages : 883
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Book Description
Completely revised new edition of the definitive reference on disorders of hemoglobin.
Author: David J. Weatherall
Publisher: John Wiley & Sons
ISBN: 0470695943
Category : Medical
Languages : en
Pages : 864
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Book Description
In the new edition of this successful and authoritative book, the thalassaemias are reviewed in detail with respect to their clinical features, cellular pathology, molecular genetics, prevention and treatment. It is aimed at specialists in haematology in the laboratory or clinical setting, particularly in areas where thalassaemia is common either in the native population or in immigrant communities. The fourth edition has been both updated and re-organized. Three new chapters have been added on the link between alpha-thalassaemia and mental retardation, on avoidance and population control and on global epidemiology. Considerable emphasis is placed on molecular pathology reflecting the huge burst of information to have come out of this field in the last few years.
Author: Ulrich Hoeger
Publisher: Springer Nature
ISBN: 3030417697
Category : Science
Languages : en
Pages : 527
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Book Description
This book focuses on respiratory proteins, the broad hemoglobin family, as well as the molluscan and arachnid hemocyanins (and their multifunctional roles). Featuring 20 chapters addressing invertebrate and vertebrate respiratory proteins, lipoproteins and other body fluid proteins, and drawing on the editors’ extensive research in the field, it is a valuable addition to the Subcellular Biochemistry book series. The book covers a wide range of topics, including lipoprotein structure and lipid transport; diverse annelid, crustacean and insect defense proteins; and insect and vertebrate immune complexes. It also discusses a number of other proteins, such as the hemerythrins; serum albumin; serum amyloid A; von Willebrand factor and its interaction with factor VIII; and C-reactive protein. Given its scope, the book appeals to biologists, biomedical scientists and clinicians, as well as advanced undergraduates and postgraduates in these disciplines. Available as a printed book and also as an e-book and e-chapters, the fascinating material included is easily accessible.
Author: Howard Franklin Bunn
Publisher: Saunders
ISBN:
Category : Medical
Languages : en
Pages : 714
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Book Description
Author: Howard Franklin Bunn
Publisher: W.B. Saunders Company
ISBN:
Category : Medical
Languages : en
Pages : 456
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Book Description
Since the dawn of the era of molecular biology, hemoglobin has been subjected to more scrutiny than any other protein, and Bunn, Forget, and Ranney can each lay claim to major contributions to the saga of hemoglobin. Their well-organized, comprehensive, and superbly illustrated work is an excellent review of the abnormal hemoglobin field. Early chapters deal with the structure and function of human hemoglobin and the way in which this is modified in various disease states. Later sections deal with the various structural hemoglobin variants and their associated clinical manifestations, the thalassaemias, and the acquired disorders of hemoglobin. The sections that deal with the modification of hemoglobin function in various disease states are particularly good. The book contains an extensive and up-to-date bibliography and is remarkably free from errors of fact or type--the best standard of reference on the subject as of the year 1977.
Author: Frank B. Livingstone
Publisher: Transaction Publishers
ISBN: 0202364038
Category : Science
Languages : en
Pages : 490
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Book Description
Research on abnormal human hemoglobins (protein in blood that carries oxygen), has taught us about the inheritance, biochemistry, and distribution of these traits. Th is knowledge, coupled with mathematical research using computer models of population genetics, has enabled researchers to marry biological fact and genetic theory. This volume places medical understanding in an evolutionary framework. Using published data on the frequencies of abnormal hemoglobins in the world's populations, Livingston analyzes and interprets these frequencies in the light of world distribution of diff erent forms of diseases such as malaria. He further develops the genetic theory of the evolutionary homeostasis. Livingston discusses the relation of abnormal hemoglobins to endemic malaria and, shows how natural selection pressures explain the known distribution of these traits. Where non-coinciding distributions arise, the book presents other genetic, anthropological, evolutionary, and epidemiological evidence to explain these discrepancies. This classic work remains a useful sourcebook for professors and graduate students of anthropology, genetics, epidemiology, and hematology. Frank B. Livingstone was professor emeritus of biological anthropology at the University of Michigan. He recieved the Martin Luther King Award from the Southern Christian Leadership Conference for his groundbreaking research on sickle cell anemia and is the author of Data on the Abnormal Hemoglobin's and Glucose-Six-Phosphate Deficiency in Human Populations. Jonathan Marks is a professor of anthropology, at the University of North Carolina, Charlotte.
Author: Anjana Munshi
Publisher: BoD – Books on Demand
ISBN: 9535121987
Category : Medical
Languages : en
Pages : 198
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Book Description
The book, Inherited Hemoglobin Disorders, describes the genetic defects of hemoglobins, disease complications, and therapeutic strategies. This book has two distinct sections. The first theme includes seven chapters devoted to the types of hemoglobinopathies, mutation spectrum, diagnostic methods, and disease complications, and the second theme includes three chapters focusing on various treatment strategies. The content of the chapters presented in the book is guided by the knowledge and experience of the contributing authors. This book serves as an important resource and review to the researchers in the field of hemoglobinopathies.
Author: Hillard M. Lazarus
Publisher: Springer
ISBN: 331997873X
Category : Medical
Languages : en
Pages : 540
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Book Description
This text provides a comprehensive overview of the essential concepts and malignancies of hematology. Now in its second edition, the book reviews every major hematologic disorder and disease entity in thorough detail, from incidence and prevalence to patient and treatment-related issues. Formatted in an organized and easy-to-read outline style to facilitate rapid learning and information processing, the book allows readers to easily locate topics of immediate interest without wading through entire sections to obtain the desired data. Written by a diverse range of experts in the field, Concise Guide to Hematology, Second Edition is a valuable resource for clinicians, residents, trainees, and entry-level fellows who work in or are just entering the field of hematology.
Author: Arthur Bank
Publisher: World Scientific
ISBN: 9812832475
Category : Medical
Languages : en
Pages : 288
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Book Description
disorders, and heart disease. It also provides new insights which may lead to new therapies." --Book Jacket.
