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Author: National Research Council
Publisher: National Academies Press
ISBN: 0309038405
Category : Science
Languages : en
Pages : 128
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Book Description
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309038405
Category : Science
Languages : en
Pages : 128
Get Book Here
Book Description
There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.
Author: Thomas F. Lee
Publisher: Springer
ISBN: 1489960228
Category : Medical
Languages : en
Pages : 322
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Book Description
Describes the ten-year, multimillion dollar Human Genome Project and its process of gene mapping; includes concerns of critics of the project.
Author: Charles R. Cantor
Publisher: John Wiley & Sons
ISBN: 0471461865
Category : Science
Languages : en
Pages : 621
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Book Description
A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchers In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features: * Topical organization within chapters for easy reference * A discussion of the developing methods of sequencing, such as sequencing by hybridization (SBH) in which data is read through words instead of letters * Detailed explanations and critical evaluations of the many different types of DNA maps that can be generated-including cytogenic and restriction maps as well as interspecies cell hybrids * Informed predictions for the future of DNA sequencing
Author:
Publisher:
ISBN: 0761354891
Category :
Languages : en
Pages : 68
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Book Description
Author: Timothy F. Murphy
Publisher: Univ of California Press
ISBN: 0520414659
Category : Medical
Languages : en
Pages : 194
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Book Description
The Human Genome Project is an expensive, ambitious, and controversial attempt to locate and map every one of the approximately 100,000 genes in the human body. If it works, and we are able, for instance, to identify markers for genetic diseases long before they develop, who will have the right to obtain such information? What will be the consequences for health care, health insurance, employability, and research priorities? And, more broadly, how will attitudes toward human differences be affected, morally and socially, by the setting of a genetic “standard”? The compatibility of individual rights and genetic fairness is challenged by the technological possibilities of the future, making it difficult to create an agenda for a “just genetics.” Beginning with an account of the utopian dreams and authoritarian tendencies of historical eugenics movements, this book’s nine essays probe the potential social uses and abuses of detailed genetic information. Lucid and wide-ranging, these contributions will interest bioethicists, legal scholars, and policy makers. Essays: “The Genome Project and the Meaning of Difference,” Timothy F. Murphy “Eugenics and the Human Genome Project: Is the Past Prologue?,” Daniel J. Kevles “Handle with Care: Race, Class, and Genetics,” Arthur L. Caplan “Public Choices and Private Choices: Legal Regulation of Genetic Testing,” Lori B. Andrews “Rules for Gene Banks: Protecting Privacy in the Genetics Age,” George J. Annas “Use of Genetic Information by Private Insurers,” Robert J. Pokorski “The Genome Project, Individual Differences, and Just Health Care,” Norman Daniels “Just Genetics: A Problem Agenda,” Leonard M. Fleck “Justice and the Limitations of Genetic Knowledge,” Marc A. Lappé This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1994.
Author: Kevin Davies
Publisher: JHU Press
ISBN: 9780801871405
Category : Medical
Languages : en
Pages : 358
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Book Description
This newly updated edition sheds light on the secrets of the sequence, highlighting the myriad ways in which genomics will impact human health for generations to come.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309070864
Category : Nature
Languages : en
Pages : 348
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Book Description
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Author: Tom Wilkie
Publisher: Univ of California Press
ISBN: 9780520085534
Category : Science
Languages : en
Pages : 216
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Book Description
The Human Genome Project has been called a scientific "search for the Holy Grail" or the genetics equivalent of the moon race. Thousands of researchers worldwide are analyzing the details of human DNA, hoping to identify all of the tens of thousands of human genes that are the blueprint for the human body. Physicist and writer Tom Wilkie offers a lively, compelling history of this scientifically fascinating and politically contentious undertaking. Beginning with the discovery of DNA by James Watson and Francis Crick in 1953, Wilkie's narrative unfolds with the intrigue of a detective story. He reviews in nontechnical terms the many step-by-step developments from different scientific teams that finally made it seem as if it would be possible to sequence the human genome. He goes on to consider the potential social consequences, good and bad, of learning to manipulate the human genetic code. What will happen as we try to prevent and cure disease or attempt to "improve" ourselves and our children by genetic means? A most readable introduction to the science of genetics and the potential consequences of the Human Genome Project, Perilous Knowledge provides background for the startling headlines that quite possibly signal changes to all human life in the next century. "After decades of painstaking research, seemingly disparate paths into the sciences of molecular biology, chemistry, biology and genetics have converged. Suddenly the scientists realize that they are . . . at the peak of a mountain where all the surrounding landscape is clear to their view. They are confident now that they can tackle one of the biggest and most profound issues in their science: unravelling the message of human inheritance."--from the Preface The Human Genome Project has been called a scientific "search for the Holy Grail" or the genetics equivalent of the moon race. Thousands of researchers worldwide are analyzing the details of human DNA, hoping to identify all of the tens of thousands of human genes that are the blueprint for the human body. Physicist and writer Tom Wilkie offers a lively, compelling history of this scientifically fascinating and politically contentious undertaking. Beginning with the discovery of DNA by James Watson and Francis Crick in 1953, Wilkie's narrative unfolds with the intrigue of a detective story. He reviews in nontechnical terms the many step-by-step developments from different scientific teams that finally made it seem as if it would be possible to sequence the human genome. He goes on to consider the potential social consequences, good and bad, of learning to manipulate the human genetic code. What will happen as we try to prevent and cure disease or attempt to "improve" ourselves and our children by genetic means? A most readable introduction to the science of genetics and the potential consequences of the Human Genome Project, Perilous Knowledge provides background for the startling headlines that quite possibly signal changes to all human life in the next century. "After decades of painstaking research, seemingly disparate paths into the sciences of molecular biology, chemistry, biology and genetics have converged. Suddenly the scientists realize that they are . . . at the peak of a mountain where all the surrounding landscape is clear to their view. They are confident now that they can tackle one of the biggest and most profound issues in their science: unravelling the message of human inheritance."--from the Preface
Author: Daniel J. Kevles
Publisher: Harvard University Press
ISBN: 9780674136465
Category : Medical
Languages : en
Pages : 420
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Book Description
Provided by Horace Freeland Judson, author of the bestselling Eighth Day of Creation. The book's broad and balanced coverage and the expertise of its contributors make The Code of Codes the most comprehensive and compelling exploration available on this history-making project.
Author: Thomas H. Murray
Publisher: Indiana University Press
ISBN: 9780253113252
Category : Medical
Languages : en
Pages : 266
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Book Description
"The volume deserves our serious attention. The authors have provided us an invaluable primer about the HGP and its implications for the future of American health care." -- Jurimetrics "This book does make a real contribution... in explaining why the genetics revolution holds so much promise and why it is so difficult to bring that promise to fruition." -- The Journal of Legal Medicine "... marked by a forward-looking, analytically and empirically grounded thematic coherence. The editors' carefully crafted template and contributions successfully focus and organize the material." -- Annals of Internal Medicine "Excellent" -- Canadian Medical Association Journal "The editors have done a very good job integrating the contents into a very useful and readable information source." -- Choice "... this highly focused book is a well-written, thoughtful, and insightful consideration of the HGP and is valuable reading for anyone concerned with the future of our country's medical infrastructure." -- Science Books & Films (**Highly recommended) "A distinguished group of scientists, lawyers, and scholars have written a coherent, readable account of the legal, medical, ethical, and policy issues many (if not all) of us will be wrestling with on both a personal and a public level, as a result of current genetic research." -- Library Journal "Each of the contributors is a distinguished authority on the topic. Ethicists, especially, will find well-developed presentation of issues, with exposition of the differing ethical assumptions in tension in the society debate." -- Doody's Health Sciences Book Review Home Page How will the science of gene mapping and gene manipulation affect health care? Leading scholars explore the clinical, ethical, legal, and policy implications of the Human Genome Project for the forms of health care, who delivers it, who receives it, and who pays for it.
