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Author:
Publisher: HARCOURT
ISBN: 9780153609411
Category : Life sciences
Languages : en
Pages : 0
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Book Description
Author:
Publisher: HARCOURT
ISBN: 9780153609411
Category : Life sciences
Languages : en
Pages : 0
Get Book Here
Book Description
Author: Patrizia Agostinis
Publisher: Springer Science & Business Media
ISBN: 9400743513
Category : Medical
Languages : en
Pages : 448
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Book Description
The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
Author: Paolo Pagano
Publisher: CRC Press
ISBN: 1315353725
Category : Science
Languages : en
Pages : 156
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Book Description
Intelligent Transport Systems (ITS) are the way forward for sustainable growth of mobility at all levels (local, regional, national, transnational). The book reviews the current status of Research & Development. It includes connected (and autonomous) cars and buses, real-world large-scale field trials, data analysis and assessment of technological solutions. Standards and normative aspects in the domain of Electronic Fee Collection and Cooperative Systems oriented to probe data collection, safety and non-safety critical applications in vehicular networks, are studied. The book provides the rational, perspectives, and technical issues for the implementation of ITS solutions in a genuine inter-modal scenario, taking the example of a Mediterranean seaport, actively involved in testing and validation of ITS standards. The novelty of this book is that it covers R&D, standards, and pilots, all under one cover. Rather than stressing the novelty in ICT, the authors have presented the need for system-level integration, assessment of existing (standard) solutions, and piloting experiments in real-world industrial scenarios.
Author: Philip J. Hashkes
Publisher: Springer
ISBN: 3319986058
Category : Medical
Languages : en
Pages : 793
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Book Description
This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.
Author: Nick Barton
Publisher: CRC Press
ISBN: 1134160135
Category : Technology & Engineering
Languages : en
Pages : 756
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Book Description
Seismic measurements take many forms, and appear to have a universal role in the Earth Sciences. They are the means for most easily and economically interpreting what lies beneath the visible surface. There are huge economic rewards and losses to be made when interpreting the shallow crust or subsurface more, or less accurately, as the case may be.
Author: David Hames
Publisher: Garland Science
ISBN: 0203967623
Category : Science
Languages : en
Pages : 460
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Book Description
A major update of the highly popular second edition, with changes in the content and organisation that reflect advances in the subject. New and expanded topics include cytoskeleton, molecular motors, bioimaging, biomembranes, cell signalling, protein structure, and enzyme regulation. As with the first two editions, the third edition of Instant Notes in Biochemistry provides the essential facts of biochemistry with detailed explanations and clear illustrations.
Author: Velio Bocci
Publisher: Springer Science & Business Media
ISBN: 904819234X
Category : Medical
Languages : en
Pages : 330
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Book Description
Oxygen-Ozone therapy is a complementary approach less known than homeopathy and acupuncture because it has come of age only three decades ago. This book clarifies that, in the often nebulous field of natural medicine, the biological bases of ozone therapy are totally in line with classical biochemistry, physiological and pharmacological knowledge. Ozone is an oxidizing molecule, a sort of super active oxygen, which, by reacting with blood components generates a number of chemical messengers responsible for activating crucial biological functions such as oxygen delivery, immune activation, release of hormones and induction of antioxidant enzymes, which is an exceptional property for correcting the chronic oxidative stress present in atherosclerosis, diabetes and cancer. Moreover, by inducing nitric oxide synthase, ozone therapy may mobilize endogenous stem cells, which will promote regeneration of ischemic tissues. The description of these phenomena offers the first comprehensive picture for understanding how ozone works and why. When properly used as a real drug within therapeutic range, ozone therapy does not only does not procure adverse effects but yields a feeling of wellness. Half the book describes the value of ozone treatment in several diseases, particularly cutanious infection and vascular diseases where ozone really behaves as a “wonder drug”. The book has been written for clinical researchers, physicians and ozone therapists, but also for the layman or the patient interested in this therapy.
Author: Z.-H. Liui
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318026514
Category : Science
Languages : en
Pages : 274
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Book Description
The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.
Author: Evan-Moor Corporation
Publisher: Daily Science
ISBN: 9781596739291
Category : Education
Languages : en
Pages : 0
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Book Description
Help your grade 5 students explore standards-based science concepts and vocabulary using 150 daily lessons A variety of rich resources including vocabulary practice, hands-on science activities, and comprehension tests in multiple-choice format help you successfully introduce students to earth, life, and physical science concepts. 30 weeks of instruction covers many standards-based science topics.
Author: M Dorak
Publisher: Garland Science
ISBN: 1134183992
Category : Medical
Languages : en
Pages : 484
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Book Description
With a variety of detection chemistries, an increasing number of platforms, multiple choices for analytical methods and the jargon emerging along with these developments, real-time PCR is facing the risk of becoming an intimidating method, especially for beginners. Real-time PCR provides the basics, explains how they are exploited to run a real-time PCR assay, how the assays are run and where these assays are informative in real life. It addresses the most practical aspects of the techniques with the emphasis on 'how to do it in the laboratory'. Keeping with the spirit of the Advanced Methods Series, most chapters provide an experimental protocol as an example of a specific assay.
