Author: Jane Gordon
Publisher: Hachette UK
ISBN: 1409194779
Category : Self-Help
Languages : en
Pages : 188
Book Description
'A jolly quest to make the greying years more colourful' The Times When journalist Jane Gordon was hospitalised and left immobile after a nasty car accident, dependent on others to feed her and help her to the bathroom, she suddenly had to confront what it might be like to one day be old and infirm. Determined to not only regain her strength but find ways to stay physically and mentally fit for as long as possible, Jane decided to road-test different self-help programmes designed to promote longevity. From ballroom dancing to brain training, learning a second language to silent meditation, joining the gym and improving her gut health, Jane seeks advice from top neuroscientists and medical professionals to assess the impact these courses have on her health, and whether they will stop her getting old before her time. Part self-help, part manifesto, How Not To Get Old is about future-proofing your physical and mental wellbeing and taking control of the ageing process, rather than wallowing in it. For what begins as a clever experiment in the art of stopping time becomes a joyous celebration of what we CAN do, not what we can't or shouldn't, and ultimately demonstrates how later life is still very much for living...
How Not To Get Old
Author: Jane Gordon
Publisher: Hachette UK
ISBN: 1409194779
Category : Self-Help
Languages : en
Pages : 188
Book Description
'A jolly quest to make the greying years more colourful' The Times When journalist Jane Gordon was hospitalised and left immobile after a nasty car accident, dependent on others to feed her and help her to the bathroom, she suddenly had to confront what it might be like to one day be old and infirm. Determined to not only regain her strength but find ways to stay physically and mentally fit for as long as possible, Jane decided to road-test different self-help programmes designed to promote longevity. From ballroom dancing to brain training, learning a second language to silent meditation, joining the gym and improving her gut health, Jane seeks advice from top neuroscientists and medical professionals to assess the impact these courses have on her health, and whether they will stop her getting old before her time. Part self-help, part manifesto, How Not To Get Old is about future-proofing your physical and mental wellbeing and taking control of the ageing process, rather than wallowing in it. For what begins as a clever experiment in the art of stopping time becomes a joyous celebration of what we CAN do, not what we can't or shouldn't, and ultimately demonstrates how later life is still very much for living...
Publisher: Hachette UK
ISBN: 1409194779
Category : Self-Help
Languages : en
Pages : 188
Book Description
'A jolly quest to make the greying years more colourful' The Times When journalist Jane Gordon was hospitalised and left immobile after a nasty car accident, dependent on others to feed her and help her to the bathroom, she suddenly had to confront what it might be like to one day be old and infirm. Determined to not only regain her strength but find ways to stay physically and mentally fit for as long as possible, Jane decided to road-test different self-help programmes designed to promote longevity. From ballroom dancing to brain training, learning a second language to silent meditation, joining the gym and improving her gut health, Jane seeks advice from top neuroscientists and medical professionals to assess the impact these courses have on her health, and whether they will stop her getting old before her time. Part self-help, part manifesto, How Not To Get Old is about future-proofing your physical and mental wellbeing and taking control of the ageing process, rather than wallowing in it. For what begins as a clever experiment in the art of stopping time becomes a joyous celebration of what we CAN do, not what we can't or shouldn't, and ultimately demonstrates how later life is still very much for living...
Ageless
Author: Andrew Steele
Publisher: Anchor
ISBN: 0385544936
Category : Science
Languages : en
Pages : 353
Book Description
“A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.
Publisher: Anchor
ISBN: 0385544936
Category : Science
Languages : en
Pages : 353
Book Description
“A fascinating look at how scientists are working to help doctors treat the aging process itself, helping us all to lead longer, healthier lives.” —Sanjay Gupta, MD Aging—not cancer, not heart disease—is the underlying cause of most human death and suffering. The same cascade of biological changes that renders us wrinkled and gray also opens the door to dementia and disease. We work furiously to conquer each individual disease, but we never think to ask: Is aging itself necessary? Nature tells us it is not: there are tortoises and salamanders who are spry into old age and whose risk of dying is the same no matter how old they are, a phenomenon known as “biological immortality.” In Ageless, Andrew Steelecharts the astounding progress science has made in recent years to secure the same for humans: to help us become old without getting frail, to live longer without ill health or disease.
Stupid Things I Won't Do When I Get Old
Author: Steven Petrow
Publisher: Citadel
ISBN: 0806541008
Category : Self-Help
Languages : en
Pages : 274
Book Description
For fans of David Sedaris and Nora Ephron, a humorous, irreverent, and poignant look at the gifts, stereotypes, and inevitable challenges of aging, based on award-winning journalist Steven Petrow's wildly popular New York Times essay, "Things I'll Do Differently When I Get Old." Soon after his 50th birthday, Petrow began assembling a list of “things I won’t do when I get old”—mostly a catalog of all the things he thought his then 70-something year old parents were doing wrong. That list, which included “You won’t have to shout at me that I’m deaf,” and “I won’t blame the family dog for my incontinence,” became the basis of this rousing collection of do’s and don’ts, wills and won’ts that is equal parts hilarious, honest, and practical. The fact is, we don’t want to age the way previous generations did. “Old people” hoard. They bore relatives—and strangers alike—with tales of their aches and pains. They insist on driving long after they’ve become a danger to others (and themselves). They eat dinner at 4pm. They swear they don’t need a cane or walker (and guess what happens next). They never, ever apologize. But there is another way... In Stupid Things I Won’t Do When I Get Old, Petrow candidly addresses the fears, frustrations, and stereotypes that accompany aging. He offers a blueprint for the new old age, and an understanding that aging and illness are not the same. As he writes, “I meant the list to serve as a pointed reminder—to me—to make different choices when I eventually cross the threshold to ‘old.’” Getting older is a privilege. This essential guide reveals how to do it with grace, wisdom, humor, and hope. And without hoarding. Praise for Stupid Things I Won't Do When I Get Old: “Unbelievably witty and relatable, I alternated bursting into laughter and placing my hand over my face in horror thinking, Oh my God, is that me? I often say, at this age we have something young people can never have…wisdom. My dear friend, Steven Petrow, has wisdom to share in this honest, funny, wry guide to keep us young at heart, without desperately hanging onto our youth. I am buying this book for all of my friends!” —Suzanne Somers, New York Times bestselling author of A New Way to Age “Stupid Things I Won’t Do When I Get Old is an irreverent, funny, honest look at aging and all the things we take for granted as normal parts of aging. They don’t need to be. If you struggle with getting older and want to find a fresh perspective on lessons learned about what NOT to do as we age, and what TO do to stay young in heart, spirit, mind and body, read this book.” —Mark Hyman, MD, #1 New York Times bestseller author of The Blood Sugar Solution 10-Day Detox Diet, and Head of Strategy and Innovation at the Cleveland Clinic Center for Functional Medicine. “Steven Petrow resolved to do things differently than his parents had when he gets old because he wished they’d been able to enjoy life more. His solution? He created a list! In this book, he shares the secrets to living a full life regardless of our age. It's all about the decisions we make every day. My advice in a nutshell: Read this book and keep it handy.” —“Dear Abby” (Jeanne Phillips), nationally syndicated advice columnist “It’s never too early to imagine what your life will look like as you age. And as I once wrote, ‘We are not hostages to our fate.’ Petrow’s book will help you plan, think, and redefine what it means to get older—and even laugh while doing it.” —Andrew Weil, MD, New York Times bestselling author of Spontaneous Healing and Healthy Aging: A Lifelong Guide to Your Well-Being “Steven Petrow not only has a great attitude about life, he is wise about how to live it. Like me, he says we should embrace our one life 100% and not let a number—our age—get in the way of anything! Steven’s book will help you rethink the word “aging” and approach this next chapter with a positive and proactive attitude. Plus, this book is fun!” —Denise Austin, renowned fitness expert, author, and columnist “Steven’s writing feels like sitting with a friend—one who is unusually gracious, warm and frank.” —Carolyn Hax, author of the nationally syndicated advice column, Carolyn Hax Praise for Steven Petrow: "Steven Petrow's Complete Gay & Lesbian Manners helps gays and straights navigate the subtleties of the same-sex world." —People "Move over, Emily Post! When it comes to etiquette for members of the gay, lesbian, bisexual and transgender community—as well as their straight friends, family members and coworkers--author and journalist Steven Petrow is the authority." —TIME "What could've easily become a novelty book has emerged as an exhaustively researched, essential resource thanks to advice columnist and etiquette expert Steven Petrow." —The Advocate "From having kids to planning funerals, Steven Petrow's Complete Gay & Lesbian Manners has most facets of gay life covered. Ms. Post would approve." —Entertainment Weekly "An indispensable refresher course...on what's proper in modern...life." —Kirkus Reviews
Publisher: Citadel
ISBN: 0806541008
Category : Self-Help
Languages : en
Pages : 274
Book Description
For fans of David Sedaris and Nora Ephron, a humorous, irreverent, and poignant look at the gifts, stereotypes, and inevitable challenges of aging, based on award-winning journalist Steven Petrow's wildly popular New York Times essay, "Things I'll Do Differently When I Get Old." Soon after his 50th birthday, Petrow began assembling a list of “things I won’t do when I get old”—mostly a catalog of all the things he thought his then 70-something year old parents were doing wrong. That list, which included “You won’t have to shout at me that I’m deaf,” and “I won’t blame the family dog for my incontinence,” became the basis of this rousing collection of do’s and don’ts, wills and won’ts that is equal parts hilarious, honest, and practical. The fact is, we don’t want to age the way previous generations did. “Old people” hoard. They bore relatives—and strangers alike—with tales of their aches and pains. They insist on driving long after they’ve become a danger to others (and themselves). They eat dinner at 4pm. They swear they don’t need a cane or walker (and guess what happens next). They never, ever apologize. But there is another way... In Stupid Things I Won’t Do When I Get Old, Petrow candidly addresses the fears, frustrations, and stereotypes that accompany aging. He offers a blueprint for the new old age, and an understanding that aging and illness are not the same. As he writes, “I meant the list to serve as a pointed reminder—to me—to make different choices when I eventually cross the threshold to ‘old.’” Getting older is a privilege. This essential guide reveals how to do it with grace, wisdom, humor, and hope. And without hoarding. Praise for Stupid Things I Won't Do When I Get Old: “Unbelievably witty and relatable, I alternated bursting into laughter and placing my hand over my face in horror thinking, Oh my God, is that me? I often say, at this age we have something young people can never have…wisdom. My dear friend, Steven Petrow, has wisdom to share in this honest, funny, wry guide to keep us young at heart, without desperately hanging onto our youth. I am buying this book for all of my friends!” —Suzanne Somers, New York Times bestselling author of A New Way to Age “Stupid Things I Won’t Do When I Get Old is an irreverent, funny, honest look at aging and all the things we take for granted as normal parts of aging. They don’t need to be. If you struggle with getting older and want to find a fresh perspective on lessons learned about what NOT to do as we age, and what TO do to stay young in heart, spirit, mind and body, read this book.” —Mark Hyman, MD, #1 New York Times bestseller author of The Blood Sugar Solution 10-Day Detox Diet, and Head of Strategy and Innovation at the Cleveland Clinic Center for Functional Medicine. “Steven Petrow resolved to do things differently than his parents had when he gets old because he wished they’d been able to enjoy life more. His solution? He created a list! In this book, he shares the secrets to living a full life regardless of our age. It's all about the decisions we make every day. My advice in a nutshell: Read this book and keep it handy.” —“Dear Abby” (Jeanne Phillips), nationally syndicated advice columnist “It’s never too early to imagine what your life will look like as you age. And as I once wrote, ‘We are not hostages to our fate.’ Petrow’s book will help you plan, think, and redefine what it means to get older—and even laugh while doing it.” —Andrew Weil, MD, New York Times bestselling author of Spontaneous Healing and Healthy Aging: A Lifelong Guide to Your Well-Being “Steven Petrow not only has a great attitude about life, he is wise about how to live it. Like me, he says we should embrace our one life 100% and not let a number—our age—get in the way of anything! Steven’s book will help you rethink the word “aging” and approach this next chapter with a positive and proactive attitude. Plus, this book is fun!” —Denise Austin, renowned fitness expert, author, and columnist “Steven’s writing feels like sitting with a friend—one who is unusually gracious, warm and frank.” —Carolyn Hax, author of the nationally syndicated advice column, Carolyn Hax Praise for Steven Petrow: "Steven Petrow's Complete Gay & Lesbian Manners helps gays and straights navigate the subtleties of the same-sex world." —People "Move over, Emily Post! When it comes to etiquette for members of the gay, lesbian, bisexual and transgender community—as well as their straight friends, family members and coworkers--author and journalist Steven Petrow is the authority." —TIME "What could've easily become a novelty book has emerged as an exhaustively researched, essential resource thanks to advice columnist and etiquette expert Steven Petrow." —The Advocate "From having kids to planning funerals, Steven Petrow's Complete Gay & Lesbian Manners has most facets of gay life covered. Ms. Post would approve." —Entertainment Weekly "An indispensable refresher course...on what's proper in modern...life." —Kirkus Reviews
Providing Healthy and Safe Foods As We Age
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309158834
Category : Medical
Languages : en
Pages : 192
Book Description
Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.
Publisher: National Academies Press
ISBN: 0309158834
Category : Medical
Languages : en
Pages : 192
Book Description
Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.
How Not To Get Old
Author: Jane Gordon
Publisher: Trapeze
ISBN: 1409194779
Category : Self-Help
Languages : en
Pages : 188
Book Description
'A jolly quest to make the greying years more colourful' The Times When journalist Jane Gordon was hospitalised and left immobile after a nasty car accident, dependent on others to feed her and help her to the bathroom, she suddenly had to confront what it might be like to one day be old and infirm. Determined to not only regain her strength but find ways to stay physically and mentally fit for as long as possible, Jane decided to road-test different self-help programmes designed to promote longevity. From ballroom dancing to brain training, learning a second language to silent meditation, joining the gym and improving her gut health, Jane seeks advice from top neuroscientists and medical professionals to assess the impact these courses have on her health, and whether they will stop her getting old before her time. Part self-help, part manifesto, How Not To Get Old is about future-proofing your physical and mental wellbeing and taking control of the ageing process, rather than wallowing in it. For what begins as a clever experiment in the art of stopping time becomes a joyous celebration of what we CAN do, not what we can't or shouldn't, and ultimately demonstrates how later life is still very much for living...
Publisher: Trapeze
ISBN: 1409194779
Category : Self-Help
Languages : en
Pages : 188
Book Description
'A jolly quest to make the greying years more colourful' The Times When journalist Jane Gordon was hospitalised and left immobile after a nasty car accident, dependent on others to feed her and help her to the bathroom, she suddenly had to confront what it might be like to one day be old and infirm. Determined to not only regain her strength but find ways to stay physically and mentally fit for as long as possible, Jane decided to road-test different self-help programmes designed to promote longevity. From ballroom dancing to brain training, learning a second language to silent meditation, joining the gym and improving her gut health, Jane seeks advice from top neuroscientists and medical professionals to assess the impact these courses have on her health, and whether they will stop her getting old before her time. Part self-help, part manifesto, How Not To Get Old is about future-proofing your physical and mental wellbeing and taking control of the ageing process, rather than wallowing in it. For what begins as a clever experiment in the art of stopping time becomes a joyous celebration of what we CAN do, not what we can't or shouldn't, and ultimately demonstrates how later life is still very much for living...
The End of Old Age
Author: Marc E. Argonin
Publisher: Da Capo Lifelong Books
ISBN: 0738219991
Category : Health & Fitness
Languages : en
Pages : 214
Book Description
The acclaimed author of How We Age, whose "descriptive powers are a gift to readers" (Sherwin Nuland), presents a hopeful and practical model of aging -- a guide to understanding how we can all make the journey better. As one of America's leading geriatric psychiatrists, Dr. Marc Agronin sees both the sickest and the healthiest of seniors. He observes what works to make their lives better and more purposeful and what doesn't. Many authors can talk about aging from their particular vantage points, but Dr. Agronin is on the front lines as he counsels and treats elderly individuals and their loved ones on a daily basis. The latest scientific research and Dr. Agronin's first-hand experience are brilliantly distilled in The End of Old Age -- a call to no longer see aging as an implacable enemy and to start seeing it as a developmental force for enhancing well-being, meaning, and longevity. Throughout The End of Old Age, the focus is squarely on "So what does this mean for me and my family?" In the final part of the book, Dr. Agronin provides simple but revealing charts that you can fill out to identify, develop, and optimize your unique age-given strengths. It's nothing short of an action plan to help you age better by improving how you value the aging process, guide yourself through stress, and find ways to creatively address change for the best possible experience and outcome.
Publisher: Da Capo Lifelong Books
ISBN: 0738219991
Category : Health & Fitness
Languages : en
Pages : 214
Book Description
The acclaimed author of How We Age, whose "descriptive powers are a gift to readers" (Sherwin Nuland), presents a hopeful and practical model of aging -- a guide to understanding how we can all make the journey better. As one of America's leading geriatric psychiatrists, Dr. Marc Agronin sees both the sickest and the healthiest of seniors. He observes what works to make their lives better and more purposeful and what doesn't. Many authors can talk about aging from their particular vantage points, but Dr. Agronin is on the front lines as he counsels and treats elderly individuals and their loved ones on a daily basis. The latest scientific research and Dr. Agronin's first-hand experience are brilliantly distilled in The End of Old Age -- a call to no longer see aging as an implacable enemy and to start seeing it as a developmental force for enhancing well-being, meaning, and longevity. Throughout The End of Old Age, the focus is squarely on "So what does this mean for me and my family?" In the final part of the book, Dr. Agronin provides simple but revealing charts that you can fill out to identify, develop, and optimize your unique age-given strengths. It's nothing short of an action plan to help you age better by improving how you value the aging process, guide yourself through stress, and find ways to creatively address change for the best possible experience and outcome.
Rehabilitation Medicine for Elderly Patients
Author: Stefano Masiero
Publisher: Springer
ISBN: 331957406X
Category : Medical
Languages : en
Pages : 533
Book Description
This book clearly explains when and how different rehabilitation techniques should be applied in the aging patient, thereby enabling readers to identify and apply those rehabilitation strategies that will maximize quality of life and functional independence in individual cases. It is specifically designed for ease of consultation and rapid retrieval of the information most relevant to clinical practice. Prominence is given to the benefits of a multidisciplinary approach to rehabilitation, with discussion of a very wide range of aspects of rehabilitation in different disease settings. The breadth of coverage is illustrated by the attention paid to less commonly addressed topics such as visual and hearing rehabilitation, the role of robotics and 3D imaging techniques, variations in approach among health care systems, and rehabilitation in end-of-life care. The authors are international academic experts in their fields, guaranteeing a high scientific standard throughout. This manual will be an invaluable tool and source of knowledge for geriatricians and physiatrists but will also appeal to a wider range of clinicians, practitioners, and students.
Publisher: Springer
ISBN: 331957406X
Category : Medical
Languages : en
Pages : 533
Book Description
This book clearly explains when and how different rehabilitation techniques should be applied in the aging patient, thereby enabling readers to identify and apply those rehabilitation strategies that will maximize quality of life and functional independence in individual cases. It is specifically designed for ease of consultation and rapid retrieval of the information most relevant to clinical practice. Prominence is given to the benefits of a multidisciplinary approach to rehabilitation, with discussion of a very wide range of aspects of rehabilitation in different disease settings. The breadth of coverage is illustrated by the attention paid to less commonly addressed topics such as visual and hearing rehabilitation, the role of robotics and 3D imaging techniques, variations in approach among health care systems, and rehabilitation in end-of-life care. The authors are international academic experts in their fields, guaranteeing a high scientific standard throughout. This manual will be an invaluable tool and source of knowledge for geriatricians and physiatrists but will also appeal to a wider range of clinicians, practitioners, and students.
You're Old, I'm Old . . . Get Used to It!
Author: Virginia Ironside
Publisher: Penguin
ISBN: 1101444282
Category : Biography & Autobiography
Languages : en
Pages : 200
Book Description
No-nonsense, wryly self-deprecating, and totally persuasive, You're Old, I'm Old...Get Used to It! unabashedly exalts the virtues of aging. Virginia Ironside wants you to know that getting old is a good thing-and not in that dreadful “sixty is the new forty” way. At sixty-five, she has no interest in pretending to be young and neither should you. Virginia celebrates all the “issues” that she and her fellow oldies embrace, including: • Talking about ailments (and the fabulous meds that come with them) • Grandchildren (the reward you get for not killing your children) • Wisdom (random disorganized knowledge you get to put a fancy label on because you're old)
Publisher: Penguin
ISBN: 1101444282
Category : Biography & Autobiography
Languages : en
Pages : 200
Book Description
No-nonsense, wryly self-deprecating, and totally persuasive, You're Old, I'm Old...Get Used to It! unabashedly exalts the virtues of aging. Virginia Ironside wants you to know that getting old is a good thing-and not in that dreadful “sixty is the new forty” way. At sixty-five, she has no interest in pretending to be young and neither should you. Virginia celebrates all the “issues” that she and her fellow oldies embrace, including: • Talking about ailments (and the fabulous meds that come with them) • Grandchildren (the reward you get for not killing your children) • Wisdom (random disorganized knowledge you get to put a fancy label on because you're old)
Sleep and Aging
Author: Mark P. Mattson
Publisher: Elsevier
ISBN: 9780444518767
Category : Medical
Languages : en
Pages : 212
Book Description
The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity
Publisher: Elsevier
ISBN: 9780444518767
Category : Medical
Languages : en
Pages : 212
Book Description
The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity
Epigenetics of Aging
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
ISBN: 1441906398
Category : Medical
Languages : en
Pages : 462
Book Description
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.
Publisher: Springer Science & Business Media
ISBN: 1441906398
Category : Medical
Languages : en
Pages : 462
Book Description
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.