Evolution of Metabolic Pathways PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Evolution of Metabolic Pathways PDF full book. Access full book title Evolution of Metabolic Pathways by R. Ibrahim. Download full books in PDF and EPUB format.
Author: R. Ibrahim
Publisher: Elsevier
ISBN: 0080531326
Category : Science
Languages : en
Pages : 481
Get Book Here
Book Description
The past decade has seen major advances in the cloning of genes encoding enzymes of plant secondary metabolism. This has been further enhanced by the recent project on the sequencing of the Arabidopsis genome. These developments provide the molecular genetic basis to address the question of the Evolution of Metabolic Pathways. This volume provides in-depth reviews of our current knowledge on the evolutionary origin of plant secondary metabolites and the enzymes involved in their biosynthesis. The chapters cover five major topics: 1. Role of secondary metabolites in evolution; 2. Evolutionary origins of polyketides and terpenes; 3. Roles of oxidative reactions in the evolution of secondary metabolism; 4. Evolutionary origin of substitution reactions: acylation, glycosylation and methylation; and 5. Biochemistry and molecular biology of brassinosteroids.
Author: R. Ibrahim
Publisher: Elsevier
ISBN: 0080531326
Category : Science
Languages : en
Pages : 481
Get Book Here
Book Description
The past decade has seen major advances in the cloning of genes encoding enzymes of plant secondary metabolism. This has been further enhanced by the recent project on the sequencing of the Arabidopsis genome. These developments provide the molecular genetic basis to address the question of the Evolution of Metabolic Pathways. This volume provides in-depth reviews of our current knowledge on the evolutionary origin of plant secondary metabolites and the enzymes involved in their biosynthesis. The chapters cover five major topics: 1. Role of secondary metabolites in evolution; 2. Evolutionary origins of polyketides and terpenes; 3. Roles of oxidative reactions in the evolution of secondary metabolism; 4. Evolutionary origin of substitution reactions: acylation, glycosylation and methylation; and 5. Biochemistry and molecular biology of brassinosteroids.
Author: Alena Orlenko
Publisher:
ISBN: 9780355133882
Category : Bioinformatics
Languages : en
Pages : 105
Get Book Here
Book Description
Molecular evolutionary analyses commonly focus on individual genes and their products without considering functional interactions necessary for organismal fitness. There is a need to understand how evolutionary forces act on multiple interacting genes together that function as components of molecular pathways and networks. A question that emerges is how stable rate-limiting steps are over evolutionary time? Although the biochemistry community has generally assumed that metabolic pathways have evolutionarily stable rate limiting steps, the idea has not been rigorously tested. Glycolysis is an essential metabolic pathway that involves a breakdown of one glucose molecule to two pyruvate molecules. Common thought is that control in glycolysis is governed by reaction free energy and pathway position. The prevailing view is that the rates of individual enzymes in glycolysis are controlled by reaction free energy and their relative positions in the pathway. Here we performed a sensitivity analysis in all available glycolysis kinetic models and discovered that rate-limiting steps varied between different species. Another approach to evaluate evolutionary instability of rate-limiting steps is to use an evolutionary computational simulation of a glycolysis-like synthetic pathway with mutation and various selective schemes. The simulations performed used combinations of selection for steady state flux. That were compared against the cost of synthesizing mRNA and proteins, and against the accumulation of high concentrations of a deleterious intermediate. Results from this study suggest that rate-limiting steps in metabolic pathways are generally not evolutionarily stable and are subject to co-evolutionary mutation-selection balance. We further hypothesized that when the system is out of equilibrium due to fluctuating selection, population size or due to positive directional selection, the evolutionary stability of rate limiting steps will have a different evolutionary dynamic. Depending upon the underlying population genetic regime, fluctuating population size was found to increase the evolutionary stability of rate limiting steps in some scenarios. This result suggests that differences in patterns of evolution when systems are in and out of equilibrium, may lead to predictable differences in observed patterns for divergent evolutionary scenarios.
Author: Eugene V. Koonin
Publisher: Springer Science & Business Media
ISBN: 1475737831
Category : Science
Languages : en
Pages : 482
Get Book Here
Book Description
Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Author: Giuseppe Fusco
Publisher: Cambridge University Press
ISBN: 1139468278
Category : Science
Languages : en
Pages : 405
Get Book Here
Book Description
Evolutionary developmental biology, or 'evo-devo', is the study of the relationship between evolution and development. Dealing specifically with the generative mechanisms of organismal form, evo-devo goes straight to the core of the developmental origin of variation, the raw material on which natural selection (and random drift) can work. Evolving Pathways brings together contributions that represent a diversity of approaches. Topics range from developmental genetics to comparative morphology of animals and plants alike, and also include botany and palaeontology, two disciplines for which the potential to be examined from an evo-devo perspective has largely been ignored until now. Researchers and graduate students will find this book a valuable overview of current research as we begin to fill a major gap in our perception of evolutionary change.
Author: Arnold H. Buss
Publisher: Amer Psychological Assn
ISBN: 9781433810312
Category : Psychology
Languages : en
Pages : 261
Get Book Here
Book Description
In Pathways to Individuality, veteran researcher and scholar Arnold Buss examines the personality traits we share with other animals-and those that set us apart from other animals, the social traits that make us distinctly human. Within those general social traits, there's much variability, as Buss explains in this new book, usually differentiated during the crucial periods of human development-and that's what makes us individuals. Humans make up the only species that has an extended period of childhood-we play and explore more than other animals-during which our human traits become canalized and differentiated: Our early interactions with our social environment influence and sharpen the neural and behavioral pathways that distinguish our distinct individuality. In turn, we seek to influence those environments we are drawn to and that help shape our individuality. Drawing from his own published research over a half-century of teaching and writing on personality, Buss masterfully summarizes key theories and recent advances in the study of temperament (aggression, dominance, etc.), the self (self-conscious shyness, self-esteem, identity), and abnormal behavior and style as crucial dimensions in understanding personality and individual differences.
Author: John T. Romeo
Publisher: Pergamon Press
ISBN: 9780080438603
Category : Science
Languages : en
Pages : 467
Get Book Here
Book Description
The past decade has seen major advances in the cloning of genes encoding enzymes of plant secondary metabolism. This has been further enhanced by the recent project on the sequencing of the Arabidopsis genome. These developments provide the molecular genetic basis to address the question of the Evolution of Metabolic Pathways. This volume provides in-depth reviews of our current knowledge on the evolutionary origin of plant secondary metabolites and the enzymes involved in their biosynthesis. The chapters cover five major topics: 1. Role of secondary metabolites in evolution; 2. Evolutionary origins of polyketides and terpenes; 3. Roles of oxidative reactions in the evolution of secondary metabolism; 4. Evolutionary origin of substitution reactions: acylation, glycosylation and methylation; and 5. Biochemistry and molecular biology of brassinosteroids.
Author: Samantha Fowler
Publisher:
ISBN: 9781739015510
Category :
Languages : en
Pages : 0
Get Book Here
Book Description
Color print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy.
Author: Jens Nielsen
Publisher: Springer
ISBN: 3540453008
Category : Science
Languages : en
Pages : 193
Get Book Here
Book Description
Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.
Author: Alessandro Minelli
Publisher:
ISBN: 9780511377716
Category : Developmental biology
Languages : en
Pages : 426
Get Book Here
Book Description
Author: National Academy of Sciences
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 388
Get Book Here
Book Description
The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.
