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Author: Michael J. Browning
Publisher: Taylor & Francis
ISBN:
Category : Medical
Languages : en
Pages : 472
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Book Description
This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Michael J. Browning
Publisher: Taylor & Francis
ISBN:
Category : Medical
Languages : en
Pages : 472
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Book Description
This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Author: Narinder K Mehra
Publisher: Boydell & Brewer Ltd
ISBN: 9788184488708
Category : Medical
Languages : en
Pages : 616
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Book Description
A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.
Author: John Lee
Publisher: Springer Science & Business Media
ISBN: 1461234549
Category : Medical
Languages : en
Pages : 337
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Book Description
This volume documents our growing understanding of the human major histocompatibility complex. The application of this information is ever more important as the limits of transplantation continue to be reduced, including the recent success of bone marrow transplantation between unrelated but closely matched individuals. In addition, the need to transfuse platelets in the face of immunologic barriers continues to challenge transfusion services. Thus, the serologic information summarized in this volume is essential for optimal patient care. At the same time, recombinant DNA technology has led to a revolution in our understanding of many aspects of basic biology. Among the advances has been the initial characterization of the structure of some HLA loci. While this will ultimately improve clinical services, constant reference to serologic data is essential so that the powerful new techniques can be applied in the most effective ways. The timing of the First Red Cross International Histocompatibility Workshop is fortunate as it brings together experts from around the world to address the state of the art. We are all grateful to Dr. John Lee and his colleagues for organizing the workshop, and for bringing together in this volume the material to be presented in Beijing during October 17-23, 1990. Leon W. Hoyer, M.D.
Author: Jan Klein
Publisher: Springer Science & Business Media
ISBN: 364284622X
Category : Medical
Languages : en
Pages : 506
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Book Description
From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a new interface has been emerging between Mhc and evolutionary genetics, and particularly the branch of evolutionary genetics dealing with molecular evolution. Mhc research relies upon molecular evolutionary genetics, with its grand superstructure of mathematical formulations, to come to grips with the events leading to and maintaining the Mhc polymorphism. Without the armament of rigorous statistical procedures developed by evolutionary geneticists, the intricate relationships among Mhc genes cannot be resolved. It will undoubtedly be a molecular geneticist who is the final arbiter in the dispute concerning the nature of the selection pressure molding the Mhc genes. And it is doubtful whether the true function of Mhc can ever be comprehended without the vantage point afforded by the elucidation of its evolutionary history.
Author: Bruce Alberts
Publisher:
ISBN: 9780815332183
Category : Cytology
Languages : en
Pages : 0
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Book Description
Author: Stephen H. Powis
Publisher: Springer Science & Business Media
ISBN: 1592592910
Category : Medical
Languages : en
Pages : 343
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Book Description
The aim of MHC Protocols is to document protocols that can be used for the analysis of genetic variation within the human major histocompatibility complex (MHC; HLA region). The human MHC encompasses approximately 4 million base pairs on the short arm of chromosome 6 at cytogenetic location 6p21. 3. The region is divided into three subregions. The telomeric class I region contains the genes that encode the HLA class I molecules HLA-A, -B, and -C. The centromeric class II region contains the genes encoding the HLA class II molecules HLA-DR, -DQ, and -DP. In between is the class III region, originally identified because it contains genes encoding components of the complement pathway. The entire human MHC has recently been sequenced (1) and each subregion is now known to contain many other genes, a number of which have immunological functions. The study of polymorphism within the MHC is well established, because the region contains the highly polymorphic HLA genes. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. As a result, large numbers of HLA alleles have been identified, a process that has been further driven by recent interest in HLA gene diversity in ethnic populations. The extreme genetic variation in HLA genes is believed to have been driven by the evolutionary response to infectious agents, but relatively few studies have analyzed associations between HLA genetic variation and infectious disease, which has been difficult to demonstrate.
Author: Bjarte G. Solheim
Publisher: Springer Science & Business Media
ISBN: 3642775063
Category : Medical
Languages : en
Pages : 431
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Book Description
With this book we· want to address young graduate students, clini cians involved in transplantation, and technicians in transplantation immunology laboratories. The volume should give a comprehensive but basic, up to date introduction to the structure, function, and clinical importance of the HLA system. We believe that there is a need for such a survey, and think that the present level of our knowledge is an optimal occasion for publication. A significant number of ques tions have now been resolved, and our knowledge has reached a level of sophistication that provides the basis for additional questions and answers. Although the emphasis of this book is on the role of HLA anti gens in clinical transplantation, their involvement in other clinical contexts is also discussed. The main focus is on the human MHC an tigenic system, but MHC systems in other species are described as they contribute to our understanding of the structural and functional characteristics of HLA antigens. Some important issues related to laboratory techniques are also covered. The contributors have a close affiliation to the field of transplan tation immunology. A majority have even been playing important roles in unraveling the HLA system and its functions. We believe this has contributed significantly to the quality and clinical and practical relevance of the book. As editors, we drew up the principal guidelines and took care that the chapters can be read as separate entities, although this invariably results in some overlapping.
Author: Robert Lechler
Publisher: Academic Press
ISBN:
Category : Medical
Languages : en
Pages : 506
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Book Description
This comprehensive and definitive work succeeds and expands on the highly successful HLA and Disease published in 1994. This new edition has been updated, redesigned and reorganised into three sections making it an invaluable reference. The introductory section summarises current knowledge on the structure, function, genetics and evolution of the HLA system. It clarifies its complex and ever changing nomenclature and discusses the mechanisms underlying disease associations with HLA alleles. The second section deals with the importance of HLA in the context of different clinical specialities. Individual chapters describe the association between HLA polymorphism and each disease. The final section features chapters on current laboratory practice in histocompatibility and tissue typing. HLA in Health and Disease is essential reading for basic and clinical researchers working in immunology and immunogenetics, transplantation medicine and autoimmunity. It will also be of interest to anyone in the fields of rheumatology, diabetology, nephrology, allergy, dermatology, neurology, endocrinology, cancer biology, respiratory medicine, haematology, molecular biology and biochemistry. Key Features Structure, function and genetics of HLA HLA nomenclature Evolution of HLA polymorphisms HLA associations in arthritis and rheumatology, renal disease, neurology, diabetes and endocrinology, gastroenterology, respiratory disease, ophthalmology, infections, dermatology and psychiatry HLA and organ transplantation Serological and PCR-based methods in HLA typing Cellular techniques in testing histocompatibility Edited and written by an international panel of experts in the field
Author: Robert Lechler
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 210
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Book Description
This text describes the genetics and products of the HLA region and their relationship to diseases including diabetes, rheumatoid arthritis and SLE. The statistical principles relevant to the design and interpretation of HLA and disease studies are presented in simple and accessible language.
