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Author: Takehiko Watanabe
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 550
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Book Description
These proceedings cover the most recent advances on histamine research from basic science to clinical medicine. Histamine is an endogenous compound that is synthesized, stored, and released primarily by mast cells and after release exerts profound effects on many tissues and organs. It is one of the cellular mediators of the immediate hypersensitivity reaction and the acute inflammatory responses, as well as primary stimulant of gastric acid secretion. A central neurotransmitter role for histamine has been also established. Histamine research has been very dynamic since it discovery in 1910. Among recent important advances are: Generation of Histamine H1, H2, H3 receptors and histidine decraboxylase (HDC) knockout mice; Clarification of the constitutive activity of the H1, H2 and H3 receptors; Characterisation of H3 receptor isoforms with distinct signaling properties; and Characterisation and cloning of the H4 receptor.
Author: Takehiko Watanabe
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 550
Get Book Here
Book Description
These proceedings cover the most recent advances on histamine research from basic science to clinical medicine. Histamine is an endogenous compound that is synthesized, stored, and released primarily by mast cells and after release exerts profound effects on many tissues and organs. It is one of the cellular mediators of the immediate hypersensitivity reaction and the acute inflammatory responses, as well as primary stimulant of gastric acid secretion. A central neurotransmitter role for histamine has been also established. Histamine research has been very dynamic since it discovery in 1910. Among recent important advances are: Generation of Histamine H1, H2, H3 receptors and histidine decraboxylase (HDC) knockout mice; Clarification of the constitutive activity of the H1, H2 and H3 receptors; Characterisation of H3 receptor isoforms with distinct signaling properties; and Characterisation and cloning of the H4 receptor.
Author: Jian-Sheng Lin
Publisher: Frontiers Media SA
ISBN: 2889194345
Category : Brain
Languages : en
Pages : 100
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Book Description
Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.
Author: S.K. Gupta
Publisher: Springer Science & Business Media
ISBN: 9780792370598
Category : Science
Languages : en
Pages : 772
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Book Description
During the past several years tremendous advancements have been made in the field of pharmacology and therapeutics. While new therapeutic strategies are coming up, old ones are being improved by modifications, or being replaced with newer ones. The major topics covered in this book include: endothelins, current topics in cardiovascular research, molecular pharmacology, recent developments in cancer research, antioxidants, oxidants and human disease, herbal drugs, developments in neuropharmacology, myelin biology and demyelinating disease, pharmacovigilance, role of cytokines in health and disease, ocular pharmacology, detoxification of xenobiotics-biotransformation and transport, and several other topics of current interest. The aim of this book is to fulfill the needs of the basic and clinical researchers as well as the students, particularly related to areas of current interest in pharmacology and therapeutics.
Author: Hirohisa Saito
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805579489
Category : Medical
Languages : en
Pages : 233
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Book Description
In this book, the editors have focused on the roles of mast cells in allergic diseases and discuss the future direction of discovering drugs. Another implication of this book is to understand mast cells at the system level. System biology is a research category to understand biology at the system level by examining the structure and dynamics of cellular and organismal functions, rather than the characteristics of isolated parts of a cell or organism.
Author: Sidney H. Weissman
Publisher: American Psychiatric Pub
ISBN: 9780880489386
Category : Medical
Languages : en
Pages : 394
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Book Description
In an era where scientific advances frequently make even the most recent scientific or medical journal articles dated soon after their publication, it is more crucial than ever for practitioners to be able to effectively evaluate new information. Using the millennium as a benchmark for surveying progress in the field, this indispensable volume captures the current state of the discipline and considers its future evolution. Key chapters by some of the field's most respected practitioners consider the impact of changing conceptual, organizational, and philosophical issues, as well as of neuroscience research findings, on the shape of the discipline. The current and future relevance of psychoanalysis; the role of social psychiatry as translator and bridge between the worlds of treatment, practice, and public policy; and the need for a new multiaxial diagnostic system that addresses motive and meaning as well as the biological and genetic contributions to behavior are just a few of the issues explored. Other chapters consider the role of genetics and molecular biology in research on mental illness; the potential uses of functional brain imaging in clinical practice; a clinical model for selecting psychotherapy and/or pharmacotherapy; and the challenge of developing research methods for assessing treatment effectiveness. Also examined are issues such as practice guidelines, managed care and the financing of mental health treatment, and the ethical conduct of the psychiatrist. The book's final chapters survey the psychiatric workforce of today and tomorrow, including its composition and education, and, finally, offer predictions about psychiatry in the next century. In Psychiatry in the New Millennium, psychiatrists and residents alike will find information vital to their understanding of both this century's psychiatric foundations and the next century's new discoveries.
Author: C. R. Ganellin
Publisher: Elsevier
ISBN: 1483193411
Category : Medical
Languages : en
Pages : 540
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Book Description
Pharmacology of Histamine Receptors presents a summary of the pharmacology of histamine receptors. It discusses the research and developments made in the use of histamine. It addresses the biological actions of the drug in various pathological instances. Some of the topics covered in the book are the classification of histamine receptors; mepyramine and related histamine antagonists; activity relationships of drugs acting at histamine receptors; chemical structure of histamine; effects of methyl substituents in histamine; enzymes involved in histamine metabolism; and histamine in body fluids. The cellular sources of histamine in tissues and blood are fully covered. The relationship of the mast cell to basophil is discussed in detail. The text describes in depth the urinary excretion of histamine and metabolites. The pathological conditions in man are presented completely. A chapter is devoted to the fundamental properties of adenylate cyclase and its measurement. The book can provide useful information to pharmacists, doctors, chemists, students, and researchers.
Author: Bill C. Coats
Publisher: iUniverse
ISBN: 0595279457
Category : Health & Fitness
Languages : en
Pages : 333
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Book Description
The First Complete Book on Aloe Vera in this Young Century. Aloe Vera The New Millennium Every once in a while, a book comes along that redefines the genre. This special 2003 edition of Aloe Vera/The New Millennium is such a work. In it you will find a wellness wellsource of new breakthroughs in Aloe Vera research and technology from the last thirty years. • Aloe Vera’s pivotal role in the new global wellness movement. • “Aloe All Stars.” Aloe Vera in the new world of Athletics. • Aloe Vera’s role in the treatment of autoimmune diseases. • AIDS, Cancer and the Aloe Answer. How Aloe Vera has broken through to these persistent dragons of world health. • New Paradigms in Personal Care. What bold new inroads Aloe Vera has made in cosmetology, skin care, aesthetics and plastic surgery. • Millennium Veterinary Breakthroughs. How many modern vets are using Aloe Vera to help our creature companions, both large and small. • Personal perspectives by the man who is acknowledged worldwide as the “father of modern Aloe Vera.” If you could only have five complete wellness guidebooks for the next dozen years, this should be one of them.
Author: András Falus
Publisher: S. Karger AG (Switzerland)
ISBN:
Category : Medical
Languages : en
Pages : 368
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Book Description
Histamine, discovered in 1910 by the British physiologist Sir Henry H. Dale, has become one of the most important biogenic amines in medicine and biology. In addition to the three well-known functions such as the contraction of smooth muscles, the increase in vascular permeability, and the stimulation of gastric acid secretion, histamine has been known to play various roles in neurotransmission, immunomodulation, the regulation of cell proliferation, etc. This book provides a comprehensive overview of histamine biology including structure, anabolic and catabolic enzymes, receptors and their ligands. It outlines the details of histamine physiology such as its role in the immune response, nutrition and neuro/psychobiology, and covers medical fields like allergy, gastroenterology, oncology, sepsis, posttraumatic stress, embryonic development and hematopoiesis. Also considered is the structural and functional genomics of histamine. Presenting the most recent advances in histamine research from basic science to clinical medicine, this book is a valuable source for students, graduates and postgraduates in medicine and the life sciences, and to anyone interested in this multifaceted molecule.
Author: K.-C. Bergmann
Publisher: Karger Medical and Scientific Publishers
ISBN: 3318021954
Category : Medical
Languages : en
Pages : 445
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Book Description
The prevalence of allergic diseases has increased dramatically over recent decades, both in terms of the number of sufferers and the number of allergies. This is a trend that has frequently been referred to as 'the epidemic of the 21st century'. As described in ancient texts, allergies have been known for over 2,000 years, but the term 'allergy' was only coined at the beginning of the 20th century when doctors began to understand their pathophysiological basis. This book presents a detailed and varied historical overview of the field of allergology. Beginning with insights on allergy from antiquity to the 20th century and the development of the associated terminology, it compiles historical reflections on the understanding of the most common allergic diseases. Important milestones in the discovery of mechanisms of allergy are described, followed by historical accounts of the detection of allergens such as pollen, dust mites, peanuts and latex, and of environmental influences such as pollution and the relationship between farmers and their environment. Several chapters illustrate the progress made in allergy management to date. Particular highlights of this book are the personal reflections of and interviews with a number of pioneers of allergy, including F. Austen, J. Bienenstock, K. Blaser, A. de Weck, A.W. Frankland, K. Ishizaka, and many more. Concluding with portrayals of allergy societies and collections, as well as being supplemented by two films, this book represents a veritable treasure trove of fascinating and richly illustrated information. Not only researchers, physicians and medical historians, but also students and even non-scientists will find History of Allergy a scientific adventure well worth reading.
Author: Torger Børresen
Publisher: Elsevier
ISBN: 1845694589
Category : Technology & Engineering
Languages : en
Pages : 612
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Book Description
It is widely accepted that increased consumption of seafood is important in dealing with growing health problems such as cardiovascular disease. Based on a major EU Integrated Research Project, SEAFOODplus, this important book reviews the range of research into consumer attitudes towards seafood and the key issues in improving the safety, nutritional and sensory quality of seafood products to meet consumer expectations.After an introductory chapter the book is divided into six parts. The first part of the book reviews consumer attitudes to seafood, including regional differences, the impact of eating quality on product preferences, consumer information needs and attitudes to processed seafood products. Part two discusses research on the important health benefits of seafood consumption in such areas as gastrointestinal health, heart disease and the health of children and young adults. In Part three, the book reviews key seafood safety issues and how they can be managed, from virus contamination and pathogens to histamine and biogenic amines. The following two parts then discuss the range of technologies designed both to optimise the sensory and health benefits of seafood and ensure animal welfare in aquaculture operations. The final part of the book reviews traceability issues.Improving seafood products for the consumer is a valuable reference for the seafood processing industry, and all those concerned with improving the consumption of seafood products. - Reviews the range of research into consumer attitudes towards seafood - Discusses key issues in improving the safety, nutritional and sensory quality of seafood products - Examines the range of technologies available to improve the quality and ensure animal welfare
