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Author: Martin H. Steinberg
Publisher: Cambridge University Press
ISBN: 0521875196
Category : Medical
Languages : en
Pages : 883
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Book Description
Completely revised new edition of the definitive reference on disorders of hemoglobin.
Author: Martin H. Steinberg
Publisher: Cambridge University Press
ISBN: 0521875196
Category : Medical
Languages : en
Pages : 883
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Book Description
Completely revised new edition of the definitive reference on disorders of hemoglobin.
Author: Ronald L. Nagel
Publisher: Springer Science & Business Media
ISBN: 1592593739
Category : Medical
Languages : en
Pages : 311
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Book Description
Hemoglobin and Hemoglobinologists This volume, Hemoglobin Disorders: Molecular Methods and Protocols, will be introduced with a review of the great milestones in the field, and the scientists responsible for those achievements. The history of hemoglobin can be divided into three periods: the Classical period, the Modern period, and the Post-Modern period. I am inclined to include as the four major members of the classical period Francis Roughton, Quentin Gibson, Jeffries Wyman, and Linus Pauling, not only because of their achievements, but also because of the superb scientists they trained and/or influenced. Francis John Worsely Roughton (1899–1972) (Fig. 1), in his laboratory at Trinity College in Cambridge, England, made the first measurements of the rapid reaction of oxygen with hemoglobin at the millisecond scale, at first by flow-mixing methods and later by flash photolysis. He not only opened an era of molecular research of hemoglobin, but also invented the methodology for fast reactions through the use of laser technology, which was later improved by others so that even faster reactions could be detected. Another contribution of Roughton was the education of Quentin H. Gibson (Fig. 2), his favorite s- dent, who, in his laboratory in Sheffield, continued to expand the horizon of ligand binding to hemoglobin, defining the oxygen binding constants for each of the hemes of hemoglobin. Though this did not, as expected, solve the und- lying mechanism of ligand cooperativity as discussed below, it was nonet- less an important milestone.
Author: Jay F. Storz
Publisher:
ISBN: 0198810687
Category : Medical
Languages : en
Pages : 258
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Book Description
Provides a synthesis of our current understanding of hemoglobin (Hb) function and evolution, and illustrates how research on this protein has provided more general insights into mechanisms of protein evolution and biochemical adaptation.
Author: Diana Nicoll
Publisher: McGraw Hill Professional
ISBN: 0071766243
Category : Medical
Languages : en
Pages : 652
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Book Description
A quick reference guide to the selection and interpretation of more than 450 commonly used diagnostic tests COVERS: Basic principles of diagnostic testing, common blood, urine and cerebrospinal fluid laboratory tests, therapeutic drug monitoring, microbiologic test selection and interpretation and diagnostic imaging tests by body system , electrocardiography, and differential diagnosis tables & algorithms Tests used in internal medicine, pediatrics, surgery, neurology and obstetrics and gynecology INCLUDES: Costs and risks of diagnostic tests Evidence-based information Diseases associated with abnormal test results, including test sensitivities Full literature citations with PubMed (PMID) numbers included for each reference More than 24 NEW clinical laboratory test entries, 6 NEW differential diagnosis tables 5 NEW diagnostic algorithms NEW sections on point-of-care testing, provider-performed microscopy, pharmacogenetic testing, and diagnostic echocardiography
Author: G.R. Honig
Publisher: Springer Science & Business Media
ISBN: 3709187982
Category : Medical
Languages : en
Pages : 460
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Book Description
The discovery in the late 1940's that sickle cell anemia is a "molecular disease" of hemoglobin was the crucial advance that gave birth to the scientific discipline of human molecular genetics. In subsequent years, with the continued expansion of knowledge about the biology and genetics of the hemoglobins, and particularly as a result of the characterization of the very large numbers of globin gene mutations, the human hemoglobin system has remained as the premier model of gene expression at the molecular level in man. With the recent explosion of new information about the genetic properties of the hemoglobins, it appears inevitable that this gene system will continue to occupy a unique position in human molecular genetics for many years in the future. Hemoglobin genetics has also recently come of age as a diagnostic and clinical discipline. The heightening of public awareness in recent years about sickle cell disease, thalassemia, and other inherited disorders has brought increasing demands for carrier detection services as well as for genetic counseling and education. The more recent development of prac tical and reliable methods for the antenatal diagnosis of hemoglobin dis orders has further increased the scope of clinical hemoglobin genetics, and it can be anticipated that these potent diagnostic techniques will have increasing application in the years ahead.
Author: Barbara J. Bain
Publisher: John Wiley & Sons
ISBN: 1394265360
Category : Medical
Languages : en
Pages : 500
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Book Description
Compact, clearly written, and well-illustrated resource for the laboratory diagnosis of haemoglobin disorders and for understanding the clinical significance of these disorders Designed as a practical resource and written in a concise and approachable format, Haemoglobinopathy Diagnosis offers a comprehensive review of the practical information needed for an understanding of the laboratory diagnosis of haemoglobin disorders. This revised and updated fourth edition covers the most recent advances in the field with new material on antenatal screening/prenatal diagnostic services, including illustrative examples and helpful questions to aid in information retention, and offers a myriad of self-assessment case studies that are ideal for the trainee. Written by two leading haematologists, the text is set in a clinical context and focuses on the selection, performance, and interpretation of the tests that are offered by the majority of diagnostic laboratories. Haemoglobinopathy Diagnosis discusses topics including: Genetics of haemoglobin synthesis and laboratory techniques for the identification of abnormalities of globin chain synthesis Thalassaemias and related conditions, and sickle cell haemoglobin and its interactions with thalassaemias with other variant haemoglobins Acquired abnormalities of globin chain synthesis or haemoglobin structure and organization of a haemoglobinopathy diagnostic service Situations when more specialist tests are required and what specialist referral centres will help to accomplish Written for trainees in haematology, practicing haematologists, laboratory scientists, and professionals in the pharmaceutical and diagnostics industries, the Fourth Edition of Haemoglobinopathy Diagnosis is an essential reference and learning tool that provides a clear basis for understanding the diagnosis of haemoglobin disorders.
Author: Martin H. Steinberg
Publisher: Cambridge University Press
ISBN: 9780521632669
Category : Medical
Languages : en
Pages : 1254
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Book Description
Disorders of Hemoglobin stands tall as the definitive work on the genetics, pathophysiology, and clinical management of hemoglobinopathies and thalassemia. Drs. Steinberg, Forget, Higgs, and Nagel have gathered the world authorities on the science and clinical management of these disorders and created the authoritative textbook for researchers and clinicians alike.Authors describe the scientific basis of clinical features and provide clinicians with a clear background of disorders they treat and scientists with an essential link between their research and its clinical manifestation. Disorders of Hemoglobin is the only single-source reference on hemoglobinopathies for hematologists, pediatricians, clinical investigators, and geneticists worldwide.
Author: Hae Won Kim
Publisher: Springer Science & Business Media
ISBN: 364240717X
Category : Technology & Engineering
Languages : en
Pages : 741
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Book Description
Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.
Author: Howard Franklin Bunn
Publisher: Saunders
ISBN:
Category : Medical
Languages : en
Pages : 714
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Book Description
Author: Richard Earl Dickerson
Publisher: Benjamin-Cummings Publishing Company
ISBN:
Category : Medical
Languages : en
Pages : 194
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Book Description
