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Author: Frederic Lawrence Holmes
Publisher: Oxford University Press
ISBN: 0195360389
Category : Science
Languages : en
Pages : 498
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Book Description
This comprehensive volume completes Frederic Holmes' notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs' research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs' formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs, from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known--the formulation of the citric acid cycle. Holmes portrays Krebs' activity at the intimate level of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmes' fascinating portrait of Krebs integrates the great scientist's investigative pathways with his personal life. The result is an illuminating analysis of both man and scientist that will be of interest to biochemists and historians of science.
Author: Frederic Lawrence Holmes
Publisher: Oxford University Press
ISBN: 0195360389
Category : Science
Languages : en
Pages : 498
Get Book Here
Book Description
This comprehensive volume completes Frederic Holmes' notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs' research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs' formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs, from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known--the formulation of the citric acid cycle. Holmes portrays Krebs' activity at the intimate level of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmes' fascinating portrait of Krebs integrates the great scientist's investigative pathways with his personal life. The result is an illuminating analysis of both man and scientist that will be of interest to biochemists and historians of science.
Author: Frederic Lawrence Holmes
Publisher:
ISBN: 9780195070729
Category : Biochemists
Languages : en
Pages :
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Book Description
Author: Nick Lane
Publisher: W. W. Norton & Company
ISBN: 0393651495
Category : Science
Languages : en
Pages : 275
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Book Description
From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.
Author: John Krige
Publisher: Routledge
ISBN: 113648339X
Category : History
Languages : en
Pages : 988
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Book Description
With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.
Author: John Krige
Publisher: Routledge
ISBN: 113440686X
Category : History
Languages : en
Pages : 978
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Book Description
With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe, and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.
Author: L.A. Stocken
Publisher: Elsevier
ISBN: 008053063X
Category : Science
Languages : en
Pages : 239
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Book Description
The account in this inaugural volume of the series covers the period 1900 to 1960, but also outlines the principal developments in earlier centuries from which biochemistry emerged. Findings are considered in the light of present knowledge, rather than in a rigid historical framework.
Author: Frederic Lawrence Holmes
Publisher: Yale University Press
ISBN: 9780300129687
Category : Science
Languages : en
Pages : 268
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Book Description
This fascinating book is an investigation of scientific creativity. Following the research pathways of outstanding scientists over the past three centuries, it finds common features in their careers and their landmark discoveries and sheds light on the nature of long-term experimental research. Frederic Lawrence Holmes begins by discussing various approaches to the historical study of scientific practice. He then explains three kinds of analysis of the individual scientific life: broad-scale, which examines the phases of a scientist’s career—apprenticeship, mastery, distinction, and maturity—over a lifetime; middle-scale, which explores the episodes within such a career; and fine-scale, which scrutinizes laboratory notebooks and other data to focus on the daily interplay between thought and operation. Using these analyses, Holmes presents rich examples from his studies of six preeminent scientists: Antoine-Laurent Lavoisier, Claude Bernard, Hans Krebs, Matthew Meselson, Franklin Stahl, and Seymour Benzer. The similar themes that he finds in their work and careers lead him to valuable insights into enduring issues and problems in understanding the scientific process.
Author: Erwin H. Ackerknecht
Publisher: JHU Press
ISBN: 1421419556
Category : Medical
Languages : en
Pages : 273
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Book Description
A bestselling history of medicine, enriched with a new foreword, concluding essay, and bibliographic essay. Erwin H. Ackerknecht’s A Short History of Medicine is a concise narrative, long appreciated by students in the history of medicine, medical students, historians, and medical professionals as well as all those seeking to understand the history of medicine. Covering the broad sweep of discoveries from parasitic worms to bacilli and x-rays, and highlighting physicians and scientists from Hippocrates and Galen to Pasteur, Koch, and Roentgen, Ackerknecht narrates Western and Eastern civilization’s work at identifying and curing disease. He follows these discoveries from the library to the bedside, hospital, and laboratory, illuminating how basic biological sciences interacted with clinical practice over time. But his story is more than one of laudable scientific and therapeutic achievement. Ackerknecht also points toward the social, ecological, economic, and political conditions that shape the incidence of disease. Improvements in health, Ackerknecht argues, depend on more than laboratory knowledge: they also require that we improve the lives of ordinary men and women by altering social conditions such as poverty and hunger. This revised and expanded edition includes a new foreword and concluding biographical essay by Charles E. Rosenberg, Ackerknecht’s former student and a distinguished historian of medicine. A new bibliographic essay by Lisa Haushofer explores recent scholarship in the history of medicine.
Author: Peter J. Ramberg
Publisher: Routledge
ISBN: 1351952455
Category : History
Languages : en
Pages : 394
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Book Description
Offering a comprehensive narrative of the early history of stereochemistry, Dr Ramberg explores the reasons for and the consequences of the fundamental change in the meaning of chemical formulas with the emergence of stereochemistry during the last quarter of the nineteenth century. As yet relatively unexplored by historians, the development of stereochemistry - the study of the three-dimensional properties of molecules - provides a superb case study for exploring the meaning and purpose of chemical formulas, as it entailed a significant change in the meaning of chemical formulas from the purely chemical conception of 'structure' to the physico-chemical conception of molecules provided by the tetrahedral carbon atom. This study is the first to treat the emergence of the unique visual language of organic chemistry between 1830 and 1874 to place in context the near simultaneous proposal of the tetrahedral carbon atom by J.H. van 't Hoff and J.A. Le Bel in 1874. Dr Ramberg then examines the research programs in stereochemistry by Johannes Wislicenus, Arthur Hantzsch, Victor Meyer, Carl Bischoff, Emil Fischer and Alfred Werner, showing how the emergence of stereochemistry was a logical continuation of established research traditions in chemistry. In so doing, he also illustrates the novel and controversial characteristics of stereochemical ideas, especially the unprecedented use of mechanistic and dynamic principles in chemical explanation.
Author: John E. Lesch
Publisher:
ISBN: 019518775X
Category : Medical
Languages : en
Pages : 377
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Book Description
In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research.
