Author:
Publisher: World Health Organization
ISBN: 9240025235
Category : Medical
Languages : en
Pages : 196

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Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309437873
Category : Science
Languages : en
Pages : 231

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Book Description
Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240095381
Category : Medical
Languages : en
Pages : 250

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Book Description
This is the 2024 update of the Compendium of WHO and other UN guidance on health and environment. The Compendium is a comprehensive collection of available WHO and other UN guidance for improving health by creating healthier environments. It provides an overview and easy access of more than 500 actions, and a framework for thinking about health and environment interventions. It covers a broad range of areas such as air pollution, water, sanitation and hygiene, climate change, chemicals, radiation, or food systems. Guidance is classified according to principal sectors involved, level of implementation (national, community, health care), the type of instrument (taxes, infrastructure etc.) and the category of evidence. The Compendium compiles existing guidance from hundreds of documents in a simple and systematized format. To ensure the most up-to-date information is provided to the end users, the Compendium is updated on a regular basis and incorporates the latest major WHO or other UN guidance on health and environment. The target audience includes any decision-makers with relevance to health and environment, and those assisting them (such as mayors, staff in ministries, UN country staff etc.). The Compendium has been prepared by WHO in cooperation with UN Environment, UNDP and UNICEF.

Author: Brij Kishore Tyagi
Publisher: Springer Nature
ISBN: 9811629641
Category : Medical
Languages : en
Pages : 455

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Book Description
This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.

Author: Andrea Wilcks
Publisher: Frontiers Media SA
ISBN: 2832540988
Category : Science
Languages : en
Pages : 166

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Author: Rebeca Carballar-Lejarazú
Publisher: CRC Press
ISBN: 1000626008
Category : Medical
Languages : en
Pages : 277

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Book Description
Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.

Author: Mark Q. Benedict
Publisher: CABI
ISBN: 1800621159
Category : Science
Languages : en
Pages : 622

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Book Description
Technology for modifying the genotypes and phenotypes of insects and other arthropods has steadily progressed with the development of more precise and powerful methods, most prominently transgenic modification. For many insect pests, there is now almost unlimited ability to modify phenotypes to benefit human health and agriculture. Precise DNA modifications and gene drive have the power to make wild-type populations less harmful in ways that could never have been performed with previous transgenic approaches. This transition from primarily laboratory science to greater application for field use has also necessitated greater development of modeling, ethical considerations and regulatory oversight. The 2nd Edition of Transgenic Insects contains chapters contributed by experts in the field that cover technologies and applications that are now possible. This edition includes increased attention to associated challenges of risk assessment, regulation, and public engagement. This book will be very valuable to students and researchers in entomology, molecular biology, genetics, public health and agriculture, and will also appeal to practitioners who are implementing the technology, and to regulators, stakeholders and ethicists.

Author: Heike Krieger
Publisher: Oxford University Press
ISBN: 0192668366
Category : Law
Languages : en
Pages : 369

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Book Description
International law is constantly navigating the tension between preserving the status quo and adapting to new exigencies. But when and how do such adaptation processes give way to a more profound transformation, if not a crisis of international law? To address the question of how attacks on the international legal order are changing the value orientation of international law, this book brings together scholars of international law and international relations. By combining theoretical and methodological analyses with individual case studies, this book offers readers conceptualizations and tools to systematically examine value change and explore the drivers and mechanisms of these processes. These case studies scrutinize value change in the foundational norms of the post-1945 order and in norms representing the rise of the international legal order post-1990. They cover diverse issues: the prohibition of torture, the protection of women's rights, the prohibition of the use of force, the nonproliferation of nuclear weapons, sustainability norms, and accountability for core international crimes. The challenges to each norm, the reactions by norm defenders, and the fate of each norm are also studied. Combined, the analyses show that while a few norms have remained surprisingly robust, several are changing, either in substance or in legal or social validity. The book concludes by integrating the conceptual and empirical insights from this interdisciplinary exchange to assess and explain the ambiguous nature of value change in international law beyond the extremes of mere progress or decline.

Author: Henry Puerta-Guardo
Publisher: BoD – Books on Demand
ISBN: 1803558520
Category : Technology & Engineering
Languages : en
Pages : 284

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Book Description
With around 3,500 species identified so far, mosquitoes can be found in virtually every environment and continent around the globe. Blood-feeding biters (e.g., Anopheles, Culex, Aedes, Ochlerotatus, and Mansonia) are among the most influential vectors for harboring and transmitting mosquito-borne diseases (MBDs) such as Zika, Japanese encephalitis, West Nile fever, dengue fever, yellow fever, and malaria, among other diseases. More than 700 million human infections and 725,000 deaths occur every year. Mosquitoes are increasing in number worldwide, yet there are still no effective vaccines or prevention strategies. Thus, traditional vector control strategies remain the most common ways to combat these diseases. Despite this, MBDs linger as one of the major challenges for public health and vector control programs at both global and local levels. This book provides a comprehensive overview of MBDs and vector control strategies.

Author: Ike Iyioke
Publisher: Ethics International Press
ISBN: 1804411000
Category : Medical
Languages : en
Pages : 261

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Book Description
This is a new treatment of clinical research ethics in an African context, and an indispensable resource for researchers, students, policy makers and research institutions interested in African research ethics. In re-appraising the African philosophical notion of selfhood, it argues for the need to re-conceptualize responsibility in clinical trials, pushing researchers to go beyond autonomy-based considerations based on the individual only, and to develop clinical trials that appropriately embed research subjects within their community and their environment. The African standpoint stresses communalism and communitarianism. As such, responsibility for, and by, the individual can only make sense through the community in which the individual is rooted. The book emphasizes the African viewpoint by making explicit the importance of the self in the re-contextualized arena of the community. It forces research ethicists to go beyond autonomy-based considerations for the individual only, and to appropriately embed research subjects within their community and their environment.