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Author: Rex A. Dwyer
Publisher: Cambridge University Press
ISBN: 9780521801775
Category : Computers
Languages : en
Pages : 360
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Book Description
This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.
Author: Rex A. Dwyer
Publisher: Cambridge University Press
ISBN: 9780521801775
Category : Computers
Languages : en
Pages : 360
Get Book Here
Book Description
This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.
Author: Mark D. LeBlanc
Publisher: Oxford University Press, USA
ISBN:
Category : Computers
Languages : en
Pages : 296
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Book Description
Publisher description
Author: Peter Schattner
Publisher: Cambridge University Press
ISBN: 1139472712
Category : Science
Languages : en
Pages : 329
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Book Description
The recent explosive growth of biological data has lead to a rapid increase in the number of molecular biology databases. Held in many different locations and often using varying interfaces and non-standard data formats, integrating and comparing data from these multiple databases can be difficult and time-consuming. This book provides an overview of the key tools currently available for large-scale comparisons of gene sequences and annotations, focusing on the databases and tools from the University of California, Santa Cruz (UCSC), Ensembl, and the National Centre for Biotechnology Information (NCBI). Written specifically for biology and bioinformatics students and researchers, it aims to give an appreciation of the methods by which the browsers and their databases are constructed, enabling readers to determine which tool is the most appropriate for their requirements. Each chapter contains a summary and exercises to aid understanding and promote effective use of these important tools.
Author: K. V. Chaitanya
Publisher: Springer Nature
ISBN: 9811507023
Category : Medical
Languages : en
Pages : 319
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Book Description
This book provides a detailed and up-to-dated information on the genomes belonging to three major life forms on Earth – archaea, prokaryotes and eukaryotes. Each section describes about the genome of a specific group of organisms, such as viruses, archaea, bacteria, eukaryotes and organellar genomes. Individual chapters provide details of their organization, structure, evolution, sequencing strategies and functions. Further, this book discusses the technologies that are applied for genome sequencing; assembly, annotation and gene prediction. Other topics include the genomes of important model organisms, mitochondria genome of Neanderthal fossil, etc. This book also examines the evolution of chloroplast and mitochondria genomes by comparing with bacteria, addresses the diseases that occur in humans due to the mutations in mitochondrial genome, gene therapy and engineering of chloroplast and mitochondrial genomes. Lastly, it features an overview of the role of proteomics, exposomics, connectomics, metabolomics, and microbiomics. This book is a fascinating read for students, lecturers and researchers in the field of genetics, genomics, microbiology and life sciences.
Author: Zhanjiang (John) Liu
Publisher: John Wiley & Sons
ISBN: 0470276339
Category : Technology & Engineering
Languages : en
Pages : 579
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Book Description
Genomics is a rapidly growing scientific field with applications ranging from improved disease resistance to increased rate of growth. Aquaculture Genome Technologies comprehensively covers the field of genomics and its applications to the aquaculture industry. This volume looks to bridge the gap between a basic understanding of genomic technology to its practical use in the aquaculture industry.
Author: Ruslan Kalendar
Publisher: Frontiers Media SA
ISBN: 2832540163
Category : Science
Languages : en
Pages : 161
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Book Description
This Research Topic is part of the Mobile Elements and Plant Genome Evolution, Comparative Analyses and Computational Tools series: Mobile Elements and Plant Genome Evolution, Comparative Analyses and Computational Tools Transposable elements are very common mobile genetic elements that are composed of several classes and make up the majority of eukaryotic genomes. The movement and accumulation of mobile genetic elements have been a major force in the formation of the genes and genomes of nearly all organisms. As dispersed and ubiquitous mobile elements, their life cycle of replicative transposition leads to genome rearrangements affecting cellular function. Transposable elements are important drivers of species diversity, and they exhibit great variety in structure, size, and mechanisms of transposition, making them important putative actors in genome evolution.
Author: Eugene D. Sverdlov
Publisher: CRC Press
ISBN: 1498713807
Category : Science
Languages : en
Pages : 271
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Book Description
This book describes the role of the obligate inhabitants of all vertebrate genomes—endogenous retroviruses, especially those emerged in genomes rather recently, during primate evolution. It specially focuses on human endogenous retroviruses as well as other retroelements.
Author:
Publisher:
ISBN:
Category : Human genome
Languages : en
Pages : 710
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Book Description
Author: Gao Jihai
Publisher: Frontiers Media SA
ISBN: 283254679X
Category : Science
Languages : en
Pages : 116
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Book Description
Author: Jung Soh
Publisher: CRC Press
ISBN: 1040053521
Category : Computers
Languages : en
Pages : 273
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Book Description
The success of individualized medicine, advanced crops, and new and sustainable energy sources requires thoroughly annotated genomic information and the integration of this information into a coherent model. A thorough overview of this field, Genome Annotation explores automated genome analysis and annotation from its origins to the challenges of next-generation sequencing data analysis. The book initially takes you through the last 16 years since the sequencing of the first complete microbial genome. It explains how current analysis strategies were developed, including sequencing strategies, statistical models, and early annotation systems. The authors then present visualization techniques for displaying integrated results as well as state-of-the-art annotation tools, including MAGPIE, Ensembl, Bluejay, and Galaxy. They also discuss the pipelines for the analysis and annotation of complex, next-generation DNA sequencing data. Each chapter includes references and pointers to relevant tools. As very few existing genome annotation pipelines are capable of dealing with the staggering amount of DNA sequence information, new strategies must be developed to accommodate the needs of today’s genome researchers. Covering this topic in detail, Genome Annotation provides you with the foundation and tools to tackle this challenging and evolving area. Suitable for both students new to the field and professionals who deal with genomic information in their work, the book offers two genome annotation systems on an accompanying downloadable resources.
