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Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309132975
Category : Medical
Languages : en
Pages : 287
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Book Description
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309132975
Category : Medical
Languages : en
Pages : 287
Get Book
Book Description
It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.
Author: Stephen S. Wachtel
Publisher: Academic Press
ISBN: 1483295583
Category : Science
Languages : en
Pages : 537
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Book Description
In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation. With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students. Reviews the genetics of sex determination in 19 up-to-date chapters Features research on sex chromosomes and sex-determining genes Includes abnormalities of sex determination and clinical genetics Written by scientists who pioneered work in this field
Author: Ursula Mittwoch
Publisher: Elsevier
ISBN: 0323158501
Category : Science
Languages : en
Pages : 268
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Book Description
Genetics of Sex Differentiation intends to help readers understand the genetic basis of sex differentiation. The book focuses on explaining how the sex chromosomes affect the process of sex differentiation by influencing the rates at which cells divide. The book is composed of seven chapters. It provides overviews of classical genetics and structure of cells. It also explains the chromosomal basis of sex determination and sex determination using Drosophila. Polygenetics and continuous and quasicontinuous variations are also discussed. The book also discusses sex factors, determination, and disorders. Moreover, it explains the heterochromatin, embryological basis of sex differentiation, and triploidy and autosomal effects. In addition, it discusses the relationship of genes, chromosomes, growth, and sex. The book is an excellent ""bedside book"" for students in biology, specifically in genetics and developmental biology. Lecturers and professionals in biology and genetics will also find this book invaluable for their practice.
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 9780470843468
Category : Science
Languages : en
Pages : 286
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Book Description
Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms. By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.
Author: Florence P. Haseltine
Publisher: Springer Science & Business Media
ISBN: 1489919651
Category : Psychology
Languages : en
Pages : 174
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Book Description
Author: R.S. Verma
Publisher: Elsevier
ISBN: 9780080526171
Category : Science
Languages : en
Pages : 368
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Book Description
The Genetical Theory of Natural Selection by R.A. Fisher (1930) dictated that sexual dimorphisms may depend upon a single medelian factor. This could be true for some species but his suggestion could not take off the ground as gender in Drosophila is determined by the number of X chromosomes. Technical advances in molecular biology have revived the initial thinking of Fisher and dictate that TDF or SRY genes in humans or Tdy in mice are sex determining genes. The fortuitous findings of XX males and XY female, which are generally termed sex reversal phenomenon, are quite bewildering traits that have caused much amazement concerning the pairing mechanism(s) of the pseudoautosomal regions of human X and Y chromosomes at meiosis. These findings have opened new avenues to explore further the genetic basis of sex determination at the single gene level. The aim of the fourth volume, titled Genetics of Sex Determination is to reflect on the latest advances and future investigative directions, encompassing 10 chapters. Commissioned several distinguished scientists, all pre-eminent authorities in each field to shed their thoughts concisely but epitomise their chapters with an extended bibliography. Obviously, during the past 60 years, the metoric advances are voluminous and to cover every account of genes, chromosomes, and sex in a single volume format would be a herculean task. Therefore, a few specific topics are chosen, which may be of great interest to scientists and clinicians. The seasoned scientists who love to inquire about the role of genes in sex determination should find the original work of these notable contributors very enlightening. This volume is intended for advanced students who want to keep abreast as well as for those who indulge in the search for genes of sex determination.
Author: Giuseppe Fusco
Publisher: Cambridge University Press
ISBN: 1108499856
Category : Medical
Languages : en
Pages : 491
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Book Description
A look into the phenomena of sex and reproduction in all organisms, taking an innovative, unified and comprehensive approach.
Author: T. J. Pandian
Publisher: CRC Press
ISBN: 1466517107
Category : Nature
Languages : en
Pages : 213
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Book Description
A comprehensive study of sex differentiation gonochoric and hermaphroditic fishes, this book examines sex chromosomes and sex determining genes, emphasizing the need to search for more than one sex-determining gene residing on different chromosomes. It traces the origin of hermaphrodites from secondary gonochores and explains the conservation of ho
Author: Gerd Scherer
Publisher: Birkhäuser
ISBN: 3034877811
Category : Science
Languages : en
Pages : 210
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Book Description
Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions.
Author: Ken Reed
Publisher: Harwood Academic Pub
ISBN: 9783718652761
Category : Science
Languages : en
Pages : 410
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Book Description
The emphasis throughout is on the genetic determinants of sex. The major issues addressed are sex chromosome differentiation, X-chromosome inactivation and the role of the Y-linked gene SRY in gonad differentiation. A combination of authoritative reviews and original articles drawn from experiment and observation on a variety of systems is complemented by the editors thoughtful introductions. 'Sex is compelling in its benefits, elegant in its conception, startling in its manifestations.' So begins this timely and thoughtful review of the most fascinating property of life. For centuries we have puzzled over the differences between males and females but only recently have we begun to understand the genetic switches that trigger the dramatic differences in form and function between the sexes. This book brings together contributions from many of the scientists who have been responsible for recent stunning advances in our understanding of sex determination and sexual differentiation. The editors have
