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Author: Mark Steven Miller
Publisher: CRC Press
ISBN: 1482268027
Category : Science
Languages : en
Pages : 288
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Book Description
Genetic Polymorphisms and Susceptibity to Disease provides a reference for established researchers in genetic research. The book provides a broad but thorough overview of how allelic gene differences influence disease susceptibility in the human population, and will be a useful reference to researchers across a range of disciplines, for example, on
Author: Mark Steven Miller
Publisher: CRC Press
ISBN: 1482268027
Category : Science
Languages : en
Pages : 288
Get Book
Book Description
Genetic Polymorphisms and Susceptibity to Disease provides a reference for established researchers in genetic research. The book provides a broad but thorough overview of how allelic gene differences influence disease susceptibility in the human population, and will be a useful reference to researchers across a range of disciplines, for example, on
Author: Syed Sameer Aga
Publisher: CRC Press
ISBN: 1000688216
Category : Science
Languages : en
Pages : 1256
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Book Description
Genetic polymorphisms are important determinants of phenotypic variations and may modulate the risk to or even cause various diseases including genetic disorders and multifactorial diseases. Genetic polymorphisms also serve as important genetic, population and evolutionary markers that allow the study of genetic and evolutionary aspects of individuals, populations and organisms and aid in tracing the evolutionary and parental lineages. Genetic polymorphisms in low penetrance genes are responsible for the alterations in the gene expression of critical signal transduction proteins and metabolic enzymes. Some of these polymorphisms are linked to increased susceptibility to various diseases especially cancers, cardiovascular diseases, immune disorders, neurological pathologies. This book collates the reviews on the roles played by polymorphisms in critical metabolic, signal transduction, cell cycle or DNA repair genes either directly or indirectly in the disease mechanisms. The focus is on various techniques for identifying the various Single Nucleotide Polymorphisms (SNPs). Polymorphism studies document the affect SNPs, and their expressions have upon the functionality of the enzymes, proteins. Key Features Describes the genetic polymorphism and its various types Discusses the role of genetic polymorphisms in modulating the risk of various human diseases Explores various molecular techniques used for detecting GPs Characterizes the role of SNPs in modulating the susceptibility of human diseases Provides a genetic basis for individual variations in response to therapeutics
Author: Narasimha Reddy Parine
Publisher: BoD – Books on Demand
ISBN: 9535135155
Category : Medical
Languages : en
Pages : 282
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Book Description
The objective of this Genetic Polymorphisms book is to rehighlight and provide few updates on the role of genetic polymorphisms in medicine and agriculture, which void emerging opinion on "full death" of genetic polymorphisms as useful genetic markers. Chapters presented here demonstrate the future benefit of SNPs in many genetic studies as well as prognosis disease and diagnosis.
Author: Yamin Liu
Publisher: BoD – Books on Demand
ISBN: 1789842018
Category : Medical
Languages : en
Pages : 166
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Book Description
Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.
Author: Aga Syed Sameer
Publisher: Springer Nature
ISBN: 9813366990
Category : Medical
Languages : en
Pages : 353
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Book Description
This book discusses the role of genetic polymorphism in susceptibility to cancers. The book explores the understanding of differences between the genetic polymorphisms and mutations.It reviews the mechanisms underlying the effect of polymorphism in genes encoding proteins that play an essential role in metabolism, signal transduction, cell cycle, and DNA repair mechanisms. Further, it investigates various techniques that are used for analyzing the genetic polymorphisms. The book contains many chapters which summarize the importance of genetic information obtained from polymorphism-based pharmaco-genetic tests to predict better drug response and life-threatening adverse reactions to chemotherapeutic agents, help in understanding of the impact of SNPs on gene function, and gives overview of the different SNP databases for examination. This book, therefore, serves as an essential guidebook for independent researchers as well as institutions working in this specialised field.
Author: Yamin Liu
Publisher:
ISBN: 9781789842029
Category : Genetics
Languages : en
Pages : 164
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Book Description
Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.
Author: Richard A. Kaslow
Publisher: Oxford University Press
ISBN: 0195174909
Category : Language Arts & Disciplines
Languages : en
Pages : 464
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Book Description
Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) concepts and methods, 2) genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. This text uniquely focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1, and deals systematically with the sequence variation/function relationships most pertinent to infection as planned for Section 2. Section 3 provides a meaningful picture of how these genes operate in infectious disease.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309112982
Category : Science
Languages : en
Pages : 300
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Book Description
The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new waysâ€"an effort requiring funding, interagency coordination, and data management strategies.
Author: Tjeerd G. Kimman
Publisher: Springer Science & Business Media
ISBN: 9780792371557
Category : Medical
Languages : en
Pages : 252
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Book Description
"Progress in the molecular analysis of genetic susceptibility to human and animal infectious diseases has been very rapid over the last few years. Several genes involved in resistance to HIV/AIDS, tuberculosis, malaria, viral hepatitis, herpesvirus infections, prion diseases, and several others have now been identified, and their functions have partly or completely been elucidated." "This book covers the most recent advances in the field and explores how progress in knowing the genetic basis of infectious diseases could lead to new insights into understanding and combating them."--BOOK JACKET.
Author: Institute of Medicine
Publisher: National Academies Press
ISBN: 0309101964
Category : Social Science
Languages : en
Pages : 385
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Book Description
Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.
